Correlação de resultados da depuração de creatinina determinada e o Clearance estimado por fórmula

O presente trabalho compara os resultados obtidos da depuração da creatinina endógena de pacientes encaminhados por solicitação médica, realizados pelo Setor de Bioquímica Clínica do CRD-NAC Unesp com protocolo do procedimento de depuração implantado na rotina laboratorial, que utiliza dados da creatinina de sangue e urina (amostra de 24 horas), com os resultados obtidos, para os mesmos pacientes, a partir das fórmulas de Cockcroft-Gault, MDRD simplificada e CDK-EPI, onde não se utiliza os valores obtidos na amostra de urina de 24 horas. E, a partir dessa análise, verifica em que casos o resultado do exame sem a amostra de urina de 24 horas correlaciona-se com o resultado da depuração da creatinina endógena realizado como procedimento de rotina e quais seriam as prováveis variáveis interferentes na aplicação destas fórmulas utilizadas em casos específicos, conforme a necessidade na avaliação clínica.

Nasal mucociliary clearance in subjects with COPD after smoking cessation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Variability in obstacle clearance may (not) indicate cognitive disorders in alzheimer disease

The aim of this study was to investigate obstacle clearance and its variability in individuals with Alzheimer dementia (AD) as well as healthy elderly individuals while they approached and crossed an obstacle in their path. Fifteen people with AD and 15 age-matched/sex-matched healthy individuals (control group) participated in this study. Clinical assessment of both groups was performed by a neuropsychiatrist. Spatial-temporal parameters of 5 trials of unobstructed walking and 5 trials of obstacle crossing during walking (approach and crossing phases) were measured using a 3-dimensional optoelectronic system. The results indicated that individuals with AD showed higher variability in the approach phase for stride length and the horizontal distance from their trailing limb foot to the obstacle. However, their gait variability in the crossing phase was similar to the control group. In addition, the individuals with AD were found to walk slowly and with a short stride length in both conditions. In conclusion, individuals with AD had increased gait variability while approaching an obstacle during walking, indicating a deficit in planning to avoid obstacles that could be related to cognitive disorders. However, gait variability during the crossing phase may not be indicative of cognitive disorders in AD.

Acute mucociliary clearance response to aerobic exercise in smokers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of oral infections on serum creatinine levels in diabetic rats

Aim: The aim of this study was to evaluate the relationship between pulpal and/or periodontal disease and serum creatinine levels in a rat model of diabetes mellitus. Methods: Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into the following 8 groups compris-ing 10 animals each: normal (G1), with pulpal disease (G2), with periodontal disease (G3), with both pulpal and periodontal disease (G4), diabetic (G5), diabetic with pulpal disease (G6), diabetic with periodontal disease (G7), and diabetic with both pulpal and periodontal disease (G8). Diabetes was induced by injecting streptozotocin, pul-pal disease were induced by exposing pulpal tissue to the oral environment, and periodontal disease was induced by periodontal ligature. After 30 days, blood was collected by cardiac puncture and the animals were killed. The maxillae were processed for histopathology. Serum creatinine levels were measured by the enzymatic method. The total assessed values were statistically analyzed by analysis of variance and Tukey’s test (p < 0.05). Results: Serum creatinine levels were significantly higher in diabetic rats than that in all normoglycemic rats (p < 0.05). The presence of pulpal and periodontal disease increased the serum creatinine levels in normoglycemic and diabetic rats, but there was no statistical difference between the groups (p > 0.05). Conclusions: We found that the serum creatinine level was higher in diabetic rats and may be related to the pres-ence of oral infections. Clinical significance: Changes in serum creatinine level may be related to the presence of oral infections and diabetes.