Nasal mucociliary clearance in subjects with COPD after smoking cessation


Autoria(s): Ito, Juliana T.; Ramos, Dionei; Lima, Fabiano F.; Rodrigues, Fernanda M. M.; Gomes, Paulo R.; Moreira, Graciane L.; Macchione, Mariangela; Toledo, Alessandra C.; Ramos, Ercy M. C.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

21/10/2015

21/10/2015

01/03/2015

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD. To determine whether smoking cessation may influence MCC and frequency of exacerbations, the following groups were evaluated: ex-smokers with COPD, smokers with COPD, current smokers with normal lung function, and nonsmokers with normal lung function. METHODS: Ninety-three subjects were divided into 4 groups: ex-smokers with COPD (n = 23, 62.4 +/- 8.0 y, 13 males), smokers with COPD (n = 17, 58.2 +/- 8.0 y, 6 males), current smokers (n = 27, 61.5 +/- 6.4 y, 17 males), and nonsmokers (n = 26, 60.8 +/- 11.3 y, 7 males). MCC was evaluated using the saccharin transit time (STT) test, and the frequency of exacerbations in the last year was assessed by questionnaire. The Kruskal-Wallis test followed by Dunn&apos;s test were used to compare STT among groups, and the Goodman test was used to compare the frequency of exacerbations. RESULTS: STT of smokers with COPD (16.5 [11-28] min; median [interquartile range 25-75%]) and current smokers (15.9 110-271 min) was longer compared with ex-smokers with COPD (9.7 [6-12] min) and nonsmokers (8 [6-16] min) (P < .001). There was no difference in STT values between smokers with COPD and current smokers, and these values in ex-smokers with COPD were similar to the control group (P > .05). The frequency of exacerbations was lower in ex-smokers with COPD compared with smokers with COPD. CONCLUSIONS: One year after smoking cessation, subjects with COPD had improved mucociliary clearance.

Formato

399-405

Identificador

http://rc.rcjournal.com/content/60/3/399

Respiratory Care. Irving: Daedalus Enterprises Inc, v. 60, n. 3, p. 399-405, 2015.

0020-1324

http://hdl.handle.net/11449/129331

http://dx.doi.org/10.4187/respcare.03266

WOS:000350898700013

Idioma(s)

eng

Publicador

Daedalus Enterprises Inc

Relação

Respiratory Care

Direitos

closedAccess

Palavras-Chave #Chronic obstructive pulmonary disease #Smoking #Mucociliary clearance #Disease exacerbation #Smoking cessation #Respiratory infections
Tipo

info:eu-repo/semantics/article