Acute mucociliary clearance response to aerobic exercise in smokers


Autoria(s): Ramos, Ercy M. C.; Vanderlei, Luiz Carlos M.; Ito, Juliana T.; Lima, Fabiano F.; Rodrigues, Fernanda Mm; Manzano, Beatriz M.; Fernandes, Rômulo A.; Cecílio, Michel J.; Toledo-Arruda, Alessandra C.; Ramos, Dionei
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

07/12/2015

07/12/2015

2015

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Processo FAPESP: 2012/09932-0

Processo FAPESP: 2012/04699-6

Mucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking. We evaluated the acute response of mucociliary clearance to aerobic exercise in smokers and nonsmokers compared with that found after acute smoking and smoking combined with exercise. Also, we investigated whether there was a correlation between mucociliary clearance and the autonomic nervous system under these conditions. Twenty-one smokers were evaluated for mucociliary clearance by saccharin transit time (STT), and the response of the autonomic nervous system was evaluated by heart rate variability after aerobic exercise, after exercise followed by smoking, after acute smoking, and after rest. For comparison, 17 nonsmokers were also assessed during exercise. Repeated-measures analysis of variance with the Tukey test or the Friedman test followed by the Dunn test was used to evaluate the STT, autonomic response, and other variables to exercise and/or smoking in smokers. A paired t test or Wilcoxon test was used to analyze responses to exercise in nonsmokers. Correlations were evaluated using Pearson or Spearman coefficients. The STT was reduced after exercise in both groups, with similar responses between them. Other stimuli also reduced the STT. The STT showed a negative correlation with sympathetic activity in smokers and a positive correlation with the parasympathetic system in nonsmokers. Although impaired in smokers, mucociliary clearance responded to the stimulus of exercise, as demonstrated by similar STTs compared with nonsmokers. This response was correlated with the autonomic nervous system in both groups. In smokers, mucociliary clearance also responded to the stimuli of smoking and exercise followed by smoking.

Formato

1575-1584

Identificador

http://dx.doi.org/10.4187/respcare.04093

Respiratory Care, v. 60, n. 11, p. 1575-1584, 2015.

1943-3654

http://hdl.handle.net/11449/131350

10.4187/respcare.04093

26264417

Idioma(s)

eng

Publicador

Daedalus Enterprises.

Relação

Respiratory Care

Direitos

closedAccess

Palavras-Chave #Aerobic exercise #Airway #Autonomic nervous system #Mucociliary clearance #Physical exercise #Smoking
Tipo

info:eu-repo/semantics/article