Degradação ruminal e síntese de proteína microbiana em bovines alimentados com silagem de sorgo contendo tanino suplementado com concentrado ou uréia

This work aimed to determine ruminal parameters of dry mater (DM), neutral detergent fiber (NDF) and protein synthesis in the rumen of animals fed diets based on sorghum with different tannin levels. In situ degradation was evaluated by rumen incubation of level 1 (L1) and level 2 (L2) sorghum silages during 0, 6, 24, 48 and 96 hours. A duplicated 4 × 4 Latin Square was used. Potential degradability (PD) of DM was similar among silages, whereas the effective degradability (ED) decreased when the diets were supplemented with concentrate. Microbial nitrogen flux and microbial synthesis efficiency were not affected by roughage source. The synthesis efficiency, expressed in organic matter and crude protein digested in rumen, was higher in L1 tannin diets supplemented with concentrate. There was not relationship between the presence of tannins and the parameters of ruminal degradation.

Síntese de sistemas estritamente reais positivos através do critério de routh-hurwitz

Given a linear time-invariant plant Gol(s) with one input and q outputs, where q > 1, a method based on the Routh-Hurwitz Stability Criterion is proposed to obtain a constant tandem matrix F ∈ ℝq, such that FGOl(s) is a minimumphase system. From this solution, the system FGol(s) is represented in state space by {A, B, FC} and a constant output feedback matrix K0 ∈ ℝ is obtained such that the feedback system {A - BK0C, B, FC} is Strictly Positive Real (SPR). The proposed procedure offers necessary and sufficient conditions for both problems. Initially, the general case, with a generic q, is analyzed. Following, the particular cases q = 2 and q = 3 are studied.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.

Experienciando Materiais Manipulativos para o Ensino e a Aprendizagem da Matemática

This paper presents some outcomes from research based on classroom experiences. The main themes are the use of mirrors, kaleidoscopes, dynamic geometry software, and manipulative material considering their possibilities for the teaching and learning of Euclidean and non-Euclidean geometries.

Zoneamento geoambiental aplicado ao planejamento da gestão ambiental e territorial do município de Colorado D'Oeste, RO

This research is based on the physical characterization of the environment to support definition of the best land use for the county of Colorado D'Oeste, in State of Rondônia, Brazil. Remote sensing and geoprocessing techniques were applied to support the preparation of a Geoenvironmental Zoning, which was used to define strategies of territorial and environmental management in that county. Digital and analogical remote sensing products, acquired by satellites, and additional cartographic and thematic maps allowed a morphostructural analysis to define low and high structural associated study site tectonic. Subsequently, this information was used to support analysis of the physiographic compartmentation of the study area. Based on this study information, it is possible to define geoenvironmental subzones and local hidrological regime, soils, mineral components, texture, color, and sedimentary materials. By integrating previous described information, a synthesis cartographic map generated. Accordingly, this Cartographic Sheet spatially defined the best land use over the study area, indicates zones for conservation, agricultural, and regeneration (areas that should be recovered). Finally, the results of this research can contribute and support governmental and non-governmental organization and local communities could improve land use and soil management, avoiding natural resource destruction and future land scarcity in the county of Colorado D'Oeste.

Esterilização de materiais termossensíveis através de aplicação de plasma gerado por descarga com barreira dielétrica (DBD)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Educação, visualidade e informação em materiais gráficos educativos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Em foco: professores de Artes e suas experiências com os materiais educativos Lá vai Maria Bem-vindo professor! arte br

Pós-graduação em Artes - IA

Ferramentas para a integração de redes de Petri e VHDL na síntese de sistemas digitais

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Uma ferramenta alternativa para síntese de circuitos lógicos usando a técnica de circuito evolutivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

TAB2VHDL: um ambiente de síntese lógica para máquinas de estados finitos

Pós-graduação em Engenharia Elétrica - FEIS

Papel do poliformismo no gene da síntese do óxido nítrico endotelial (ENOS) na posição G894T na resposta pressórica em mulheres no climatério: efeito do treinamento físico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Pesquisa e desenvovimento de novos materiais microporosos e mesoporosos para uso em ressonância magnética nuclear por imagem como agentes de contraste

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desempenho e estabilidade de parâmetros bioquímicos em materiais de controle líquidos congelados e sólidos liofilizados

Pós-graduação em Biociências e Biotecnologia Aplicadas à Farmácia - FCFAR

Peptídeos derivados da proteína bacteriana YacG : síntese e estudos de estrutura-função

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)