Otimização da síntese para obtenção de Lapdesf ibu-tau e ibu-ftd e ensaio de toxicidade pré-clínica dose única (aguda) e doses repetidas em camundongos

A inflamação é basicamente uma resposta de proteção tissular cuja função é proteger o organismo de micro-organismos e toxinas que promovem a lesão celular. A resposta inflamatória gera o aparecimento dos quatro sinais cardinais dor, edema, calor e rubor podendo posteriormente ocorrer a perda de função do tecido ou órgão. Os anti-inflamatórios não esteroides (AINEs) promovem sua atividade alterando a atividade de prostaglandinas (PGs), por inibição das isoformas de ciclo-oxigenases constitutivas (COX1) e induzidas (COX2). A inibição não seletiva destas enzimas (por AINEs clássicos) gera reações adversas graves, como as reações gastrointestinais, em pacientes pré-dispostos e/ou que as utilizam por um período prolongado. Os AINEs de segunda geração (inibidores seletivos de COX2), também se mostraram tóxicos, podendo causar alterações cardiovasculares. Neste sentido, o planejamento de novos compostos com atividade anti-inflamatória e destituídos de toxicidade ainda é um desafio para a química farmacêutica e medicinal. Dois derivados de ibuprofeno (AINE clássico) foram obtidos anteriormente no Lapdesf por Castro (2008) e Vizioli (2006), demonstrando atividade anti-inflamatória em modelo de inflamação aguda (edema de pata) e crônica (colite ulcerativa), destituídos de gastroulceração (VIZIOLI, 2009). Diante destes resultados o presente estudo visou à preparação dos compostos e o estudo pré-clínico de toxicidade em dose única (aguda) e em doses repetidas em camundongos, bem como as análises comportamentais, histopatológicas dos órgãos e ensaios bioquímicos. Os achados comportamentais, bioquímicos e histopatológicos permitem concluir que não foi observada toxicidade nos modelos estudados, exceto para o grupo de administração dose única de 2000 mg/kg via intraperitoneal do composto Lapdesf ibu-tau.

Construção de um equipamento de ensaio de desgaste micro abrasivo por esfera rotativa fixa para análise do desgaste em revestimento duro aplicado por soldagem

Pós-graduação em Engenharia Mecânica - FEIS

Desenvolvimento de sistema eletrônico para instrumentar um DPL em ensaio dinâmico de resistência do solo

Pós-graduação em Engenharia Elétrica - FEIS

Traduzir Lucano em português: ensaio de poética tradutória sincrônica

The aim of this paper is to offer an essay of synchronous translation poetics, based on the theoretic thought of Haroldo de Campos and Antoine Berman, which highlight the relevance of translation history in the work of contemporary translators. For this purpose, starting from a close-reading of the first seven Latin hexameters of Lucan’s Pharsalia, I present a comparative study of the translations of Filinto Elisio (18th century), José Feliciano de Castilho (19th century) and Vieira (2011).

Dureza e rugosidade superficial de cimentos de ionômero de vidro após ensaio de escovação

To evaluate the surface roughness and Vickers hardness of glass ionomer cements Ketac Molar® and Ketac Molar Easy Mix® (ESPE Dental AG) after brushing. Methods – After roughness and hardness tests of 14 specimens of each material, they were submitted to 30,000 brushing cycles and new analysis of roughness and hardness. Statistical analysis showed that there was no significant difference between the materials in relation to the initial roughness. Results – However, after brushing there was higher surface roughness for Ketac Molar Easy Mix®. For both materials, there was increase of hardness after brushing and the highest values were presented by Ketac Molar Easy Mix®. Conclusion – It can be concluded that, when choosing a glass ionomer cement for restoration it should be preferred to Ketac Molar, because it showed hardness similar to Ketac Molar Easy Mix, but it was less rough.

O centenário da ferrovia brasileira (1954): ensaio sobre a elabo-ração da memória ferroviária no Brasil

In 1954, it was celebrated the centenary of railways in Brazil. The date refers to the first section of 14.5 km of railway in Brazil (30/04/1854), in Rio de Janeiro, between Mauá and Fragoso, of the Petropolis Railway Company (Estrada de Ferro Petrópolis). Some of the texts and commemorative events indicated the symbolic values that the railroad took in the Brazilian history. Firstly, on 30.04.1954, the railway section Mauá-Fragoso and steam locomotive “Baroness” (the first used on the track) were declared national monuments(Decree No. 35,447-A, April 30, 1954). Secondly, some entities (Clube de Engenharia, Conselho Nacional de Geografia, Ministério da Viação e Obras Públicas) highlighted the importance of celebrating the Brazilian railway history and its historical significance, economic and geographical. For this, some events was occurred (the commemoration of one hundred years in Rio de Janeiro and Recife on 30.04.1954). Among the texts wrought produced, we highlight the text I Centenary of Brazilian Railroad (1954), released by the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística), and the National Council of Geography (Conselho Nacional de Geografia). The emphasis given to the railway refersto the geographical perspective (territorial expansion), but also makes mention of the Barãode Mauá, the founder of Petropolis Railway Company. We aim to understand the celebration from evocations about the Brazilian railroad history and some ideas that is assigned to the railway (and the Barãode Mauá), and railway heritage (the track and the locomotive “Baroneza”). On basis of this review will seek to understand how it was reconceived the railroad memory in view of these values and material elements.

Estudo das alterações bioquímicas em sangue e diferentes órgãos de Phrynops geoffroanus (Schweigger, 1812) (Testudines: Chelidae) coletados em ambiente contaminado ou expostos ao benzo[a]pireno

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos imediatos e tardios da imersão em água pós-exercício: uma revisão sistemática e um ensaio clínico randomizado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeitos do treinamento resistido na síndrome metabólica: uma revisão sistemática com meta-análise e um ensaio clínico randomizado

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Exercício físico resistido em pacientes com doença renal crônica em hemodiálise: ensaio clínico randomizado controlado

Pós-graduação em Fisioterapia - FCT

A pesquisa em psicologia: ensaio sobre a Psicologia enquanto ciência, a pesquisa qualitativa e o uso da entrevista como principal instrumento de coleta de dados

For constituting itself a science, Psychology has coursed along way. From the time he was considered a Philosophy’s discipline until to be recognized as a legitimate science, Psychology had to devoteto the definition of its object of study, the development and refinement of theoretical-methodological frameworks and, in particular, to consolidation process of their research strategies and knowledge construction. Therefore, in order to regard the demands of the classical scientific paradigm, which is very influenced by Positivism, Psychology made use, initially, of quantitative methodology and laboratory research. This article presents some of the process of identity construction of Psychology as a science, focusing on its transition path between the quantitativist paradigm of scientific knowledge production to the qualitativist paradigm, until that is more commonly practiced nowadays: the collaborative use of these methodological strategies. For presenting the qualitative researching Psychology, we discussed, beyond its proposal and differentiation elements in relation to quantitative research, the different methods used for this mode and, in particular, the interview - which is considered the main way of data collection in surveys conducted by psychologists and, therefore, it is an important element the process of knowledge building that science, in addition to being the most qualified space for dialogue between there searcher and the research subject.

Dispositivo estratégico, resistência e relações de poder: um ensaio sobre a identidade do Centro de Educação Matemática (CEM) e seu papel na (E)educação (M)matemática brasileira

This paper presents some results of the investigation on the Mathematical Education Centre (CEM), a group of mathematics teachers’ educators in São Paulo, Brazil, acting mainly between 1984 and 1997. The essay, marked by an effort to constitute the identity of the CEM based on Foucault, assumes that the identity constitution process is not about what CEM is or was, but mainly about a set of possibilities of apprehending it from its historically contextualized strategies and initiatives. In this Foucauldian reading, which brings about concepts such as "strategic device", "resistance" and "power relations", the CEM constitution appears while it creates conditions for the constitution of Brazilian modern mathematical education.

As matemáticas modernas: um ensaio sobre os modos de produção de significado ao(s) movimento(s) no ensino primário brasileiro

The main goal of this paper is to discuss the production of meaning of the Modern Math Movement. The main sources were data available in school archives and interviews with former teachers that we use in order to focus on the diversity of perspectives -that complement it or oppose it-, which comes up when teachers refer to the Movement. Using this process of signification, teachers whether accept it, invalidate it or adapt it to guidelines imposed to them in their teaching activities. We establish a methodology by following the premises of Oral History to gather oral testimonies. The theoretical foundations in which this article is written are the guidelines of Paul Ricoeur’s Hermeneutics, John Thompson’s Depth Hermeneutics and Bolívar’s narrative analysis.