Estabilização de órbitas periódicas instáveis utilizando controle por modos deslizantes com compensação adaptativa

The chaotic behavior has been widely observed in nature, from physical and chemical phenomena to biological systems, present in many engineering applications and found in both simple mechanical oscillators and advanced communication systems. With regard to mechanical systems, the effects of nonlinearities on the dynamic behavior of the system are often of undesirable character, which has motivated the development of compensation strategies. However, it has been recently found that there are situations in which the richness of nonlinear dynamics becomes attractive. Due to their parametric sensitivity, chaotic systems can suffer considerable changes by small variations on the value of their parameters, which is extremely favorable when we want to give greater flexibility to the controlled system. Hence, we analyze in this work the parametric sensitivity of Duffing oscillator, in particular its unstable periodic orbits and Poincar´e section due to changes in nominal value of the parameter that multiplies the cubic term. Since the amount of energy needed to stabilize Unstable Periodic Orbits is minimum, we analyze the control action needed to control and stabilize such orbits which belong to different versions of the Duffing oscillator. For that we will use a smoothed sliding mode controller with an adaptive compensation term based on Fourier series.

O papel do centro histórico na cidade: um estudo comparativo entre João Pessoa e Tours

In the contemporary scene, it is conspicuous that the patrimony and the culture have assumed privileged positions in urban policies, presenting themselves as instruments for transforming and shaping the aspect of cities. In the plot line of such glowing trend, the competitiveness among cities has drawn more attention, for at present such urban centers garner an image that makes them suitable for economic purposes, thus more likely to attract investments and tourists. In the spotlight of such stage, the cities become notable actors, directed by policies of urban rehabilitation. In such plot line, the historical centers gain more visibility and are converted into venues for staging the spectacle of everyday life. Overlapped in this process of producing images, the phenomenon of gentrification recrudesces. Thus, the discussion threaded about the patrimony gains strength in urban studies, keeping a close relationship with the ways of perceiving the cities nowadays. This work is based on the principle that the historical centers are engendered and fond by urban policies, working as transforming instruments of city perceptions and living. In that sense, the way how the historic center and the valuation assessed to old buildings are comprehended by the inhabitants is largely guided by urban policies that outline a sellable image of the city. In the light of such elaborations, an ethnographic research was made with focus on two different contexts, namely: the historic centers of João Pessoa (Brazil) and Tours (France). It was done in a comparative perspective, for it allows us to trace the main specificities of each situation in order to highlight the similarities and distinctions about the two regions mentioned above. The research aimed at apprehending how the pair redevelopment-abandonment engendered by the urban policies influence on the process of revaluation of historical centers by dwellers and to what extent there are convergences regarding such kinds of interventions, as an object of policies of urban and touristic development in Brazil and France. In order to make this work – besides the abundant bibliographic review carried out in libraries of several universities and institutions in Brazil and France – dwellers, merchants, teachers, representative people of public agencies and former residents of the historic centers of both cities were interviewed. In Tours, immigrants/Portuguese descendants were interviewed, point that greatly contributed to the understanding of the historic center before Vieux Tours renewal and restoration. Moreover a rich research on Archives and Public Agencies was done, as well as investigations on newspaper and articles on the Internet. Thus, in the context of the ethnography in historic centers, it was possible to notice that both realities reveal similarities in a comparative analytical framework

Humanização do direito e da justiça: reconhecimento e efetividade dos direitos da criança e do adolescente

The crisis of the model of technical and formal rationality is discussed in light of a paradigmatic change of the Law that arises in the context of recent transformations of capitalism worldwide, proposing a humanization of Law and Justice with a new ethical-political foundation that promotes a reconciliation between the rules that governs the social order and the world of life, a process of society’s emancipation. As empirical cut it is taken the Right of Children and Youth and, in a practical perspective, the recognition and effectiveness of the Rights of Children and Adolescents in Brazil. It is proposed to analyze the process of democratization and legitimacy of the children and youth rights from the study and apprehension of knowledge that advocate a multidisciplinary view of knowledge and a dialogic praxis for construction of a thought able to contribute to the analysis of public policies and to develop strategies that allow a real change on the social thinking about the doctrine of integral protection of children and adolescents. The proposed methodological approach was developed from a dialectical view of science and as a research strategy for data collection of symbolic cartography or cartographic sociology of law and justice. It is shown that in the process of humanization of the Law and Justice there is a gap between the rights and the democratic participation of these rights.

Expansão imobiliária na cidade de João Pessoa, no período de 2009-2013: um caso de formação de bolha?

The housing boom recorded in recent years in the city of João Pessoa contributed decisively to the increase in housing supply across the all territory. This advance, however, was accompanied by a significant increase in property prices, which in itself generates enormous expectations on the support of the same medium and long term. From this apparent frame heating the housing market of this Capital. This study empirically examined whether this enhancement configured a typical process of bubble formation between the years 2009 and 2013 in this part of Capital. The empirical price dynamics of the housing market , was based on the indicators of price, rent and cost developed by Bezerra et al. (2013). The results of these local indicators increase the degree of confidence in the hypothesis seen, whatever, that the movement of prices in the main districts of the city of João Pessoa is a real estate bubble

A tematização do espaço público e a economia criativa local: estudo de caso a partir do "maior São João do mundo", em Campina Grande-PB

The thematization of public space in the ―Maior São João do Mundo‖ in Campina Grande - PB stimulates the economy and the local tourism from the transformation of a common public space in a setting that has the traditional June festivals based. To do so, contributes to promotion of existing creative sectors in the city and the design of a new city that is projected from the festivities of São João. In this research we propose to determine the influence of the thematization of public space in the local economy, particularly in creative sectors present in the ―Maior São João do Mundo‖ and assess their importance for the development of local creative economy. We chose the case study, from an ethnographic approach, using different research techniques such as participant observation, semi-structured interviews with open questions and the analysis of social representations of respondents. The methodology used is mixed because it involves qualitative and quantitative data. We could notice at the end of this research, the thematization of public space in the ―Maior São João do Mundo‖ is the main reference factor for the event, stimulating the local economy and changing the city's image in three levels: political, economic and social. Also realize that the thematization of public space is the key binding factor between the creative sectors as well as between them and the related activities. All these sectors serve as a link between the products and services, creating a harmonic whole that transforms the city's image, stimulates the economy, promotes social inclusion, cultural integration and keeps the ―Maior São João do Mundo‖ as a traditional event in the tourist calendar regional and national.

Dar a ver Sertão e Sevilha: matizes hispânicas na poética de João Cabral de Melo Neto

Dar a ver Sertão e Sevilha: matizes hispânicas na poética cabralina is a study on the lyric reading possibilities of Cabralian poetry, from the work of the poet from Pernambuco, that shows the intercultural dialogue and the Spanish poetical approach absorbed by João Cabral de Melo Neto during his Andalusian experience. Hispanic interfaces incorporated by the Cabralian poetry through literature or through the direct contact with the culture are registered on the 133 poems that have Spain as theme, in which we can see the matrix of Hispanic tradition, rich in its diversity, was the preponderant element for the poet João Cabral to discover the core of his lyric backwards. From Hispanic corpus, it will be explored the aesthetical assimilation of Spanish poetry in the work of João Cabral de Melo Neto, with the objective of demystifying the issues of lyrical dullness and anti musicality on Cabralian poetics in which, from the appropriation of Hispanic elements investigated as a signal of lyrics and musicality, originates a reading unattached from the constructivist signal, tessitura evidenced by the critic Antonio Candido since the origin of JCMN poetry with the poem Pedra do sono (1942). The mentioned aesthetics was adopted later on by the literary critics that named it as “brain poetry” for its hermetical configuration, tessitura of rigor, concreteness of language and stiff metrics. The results obtained from this study aim to induce a reading that favors the lyrical acoustic of the Cabralian poetry in the effort to ease the aspects of the arid construction.

Moléculas coestimulatórias na leishmaniose visceral

Visceral leishmaniasis (VL) is endemic in many countries, including Brazil. The protozoan Leishmania infantum, is the etiological agent of VL, and is transmitted by the bite of female sandflies during the blood meal. The majority of subjects when exposed to the parasite do not develop the disease, because of development of Th1 cellular responses. Those who have develop signs of VL such as fever, weight loss, hepatosplenomegaly, have impairment of the cellular immune response, specific to the Leishmania antigens. We evaluated whether the specififc anergy during symptomatic VL, may be associated with changes in T cells costimulatory molecules or their ligands in CD14+ monocytes. There is an increase in CTLA-4 porcentage on CD4+ T lymphocytes (p=0.001) and ICOS on CD4+ and CD8+ T cells (p=0.002 to CD4+ and p=0.003 to CD8+), after stimulation by soluble Leishmania antigen (SLA) during active visceral leishmaniasis, and that there is a higher percentage of these molecules ex vivo, when comparing symptomatic to recovered individuals (p=0.04 to CTLA-4 in CD4+, and p=0.001 to ICOS in CD4+ and p=0.026 to CD8+). Moreover, we found a high gene expression of CTLA-4, OX-40 and ICOS during active VL. CD40, CD80, CD86, HLA-DR and ICOSL molecules do not suffer changes during disease. There is IFN-γ production by the peripheral blood cells, after SLA stimulation, by peripheral blood cells in symptomatic subjects; however, there is a decrease of the ratio IFN-γ/IL-10, which is reversed after clinical recovery. The impairment of some costimulatory molecules pathways during symptomatic VL could inhibit the ability of phagocytes to kill Leishmania and could facilitate their survival and the proliferation inside macrophages.

Avaliação da biodegradação do dibenzotiofeno utilizando lodos ativados

During the oil refining process a huge discard volume of water occurs, which carries the contaminants from the process. A class of contaminant compounds resulting from the petrochemical industry are the Polyaromatic Hydrocarbons (PAH's). To evaluate the biodegradation of Dibenzothiophene in refinery water a synthetic wastewater was prepared to be treated using activated sludge. For this, a 2 3 Composite Design (plus 3 central points and six axial points) was carried out. The planning had as independent variables (factors) the initial concentration of DBT, pH and time of biodegradation. Biodegradation of DBT was assayed following the parameters COD, pH, temperature, SS, VSS, FVS, SVI. Concerned to the chromatographic conditions, a methodology was validated in order to verify the presence of DBT and its metabolite, 2-HBF, in the final wastewater treated by activated sludge system using a liquid - liquid extraction coupled to HPLC / UV analysis. The parameters used for validation were DL, QL, linearity, recovery and repeatability. As for optimization, the results indicated that the studied methodology can be used in monitoring the DBT degradation and 2- HBF by activated sludge, as they showed excellent linearity values, coefficients of variation, so as satisfactory recovery percentage. COD reduction efficiency tests showed an average percentage of 64.4%. The increasing trend for the results for the TSS and VSS tests showed that the activated sludge was well tailored. The best operating conditions for the reduction of COD were observed when operated with median concentrations of DBT, a higher time to biodegradation, and pH in both the acidic range as the basic one. The biodegradability of the DBT was confirmed by determining the presence of HBF-2. The highest concentrations of HBF-2 were obtained in extreme concentrations of DBT and pH, and higher biodegradation times.

Síndrome de Guillain-Barré: epidemiologia, prognóstico e fatores de risco

Introduction. Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy and the principal cause of acute neuromuscular paralysis. The most prominent GBS subtypes are: acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Fisher syndrome (FS). Differences in geographical distribution of variants have been reported. In Brazil, there are few studies describing the characteristics of GBS, but none on the frequency of GBS variants and their clinical manifestations. Infection-induced aberrant immune response resulting from molecular mimicry and formation of cross-reacting antibodies, contribute to complement activation. Functional biallelic polymorphism in immunoglobulin receptors that influence the affinity of IgG subclasses and the type of immune response have been described, suggesting genetic susceptibility to developing disease. It remains unclear whether individuals carrying different FCGR alleles have differential risk for GBS and⁄or disease severity. The goals of this study were: (1) To characterize GBS and describe the clinical findings in a cohort of patients with GBS from the state of Rio Grande do Norte, Brazil; (2) to determine whether polymorphism in FCGR were associated with development of GBS, and (3) to tease out whether the global gene expression studies could be a tool to identify pathways and transcriptional networks which could be regulated and decrease the time of disease. Methods. Clinical and laboratory data for 149 cases of GBS diagnosed from 1994 to 2013 were analyzed. Genomic DNA and total RNA were extracted from whole blood. Antigangliosides antibodies were determined in the sera. In addition, we also assessed whether FCGR polymorphism are present in GBS (n=141) and blood donors (n=364), and global gene expressions were determined for 12 participants with GBS. Blood samples were collected at the diagnosis and post-recovery. Results. AIDP was the most frequent variant (81.8%) of GBS, followed by AMAN (14.7%) and AMSAN (3.3%). The incidence of GBS was 0.3 ⁄ 100,000 people for the state of Rio Grande do Norte and cases occurred at a younger age. GBS was preceded by infections, with the axonal variant associated with episodes of diarrhea (P = 0.025). Proximal weakness was more frequent in AIDP, and distal weakness predominant in the axonal variant. Compared to 42.4% of cases with AIDP (P<0.0001), 84.6% of cases with the axonal variant had nadir in <10 days. Individuals with the axonal variant took longer to recover deambulation (P<0.0001). The mortality of GBS was 5.3%. A worse outcome was related to an axonal variant (OR17.063; P=0.03) and time required to improve one point in the Hughes functional scale (OR 1.028; P=0.03). The FCGR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls (FCGR2A p=0.367 and FCGR3A p=0.2430). Global gene expression using RNAseq showed variation in transcript coding for protein isoforms during acute phase of disease. Conclusions. The annual incidence of GBS was 0.3 per 100,00 and there was no seasonal pattern. A predominance of the AIDP variant was seen, and the incidence of the disease decreased with age. The distribution of weakness is a function of the clinical variants, and individuals with the axonal variant had a poorer prognosis. Early diagnosis and variant identification leads to proper intervention decreasing in long-term morbidity. FCGR polymorphisms do not seem to influence susceptibility to GBS in this population. This study found deregulated genes and signs of transcriptional network alterations during the acute and recovery phases in GBS. Identification of pathways altered during disease might be target for immune regulation and with potential to ameliorate symptoms.