9 resultados para Aquin, Hubert

em Deakin Research Online - Australia


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Because outsourcing of information systems (IS) is now widespread, it is generally assumed to be successful. It is also often assumed that outsourcing risks are easily managed. In this paper we adopt an “evidence based management” approach to first test these assumptions through a qualitative metaanalysis of academic studies into IS outsourcing outcomes. Our research reveals a shortage of reliable and valid evidence for outsourcing’s benefits, and for the level of risk involved. We then use data from a series of focus groups to explain the paradox of widespread adoption of a strategy with limited empirical support. These focus groups were interpreted through the lens of research on a
range of cognitive mechanisms and biases that are known to affect decision makers. We conclude that cognitive mechanisms that are likely to affect sourcing decisions include framing biases, cognitive dissonance, attribution error, and the “optimism”, “confirmation”, “disconfirmation” and “overconfidence” biases. Given the shortage of supporting evidence, and the potential for these biases to operate, we argue that researchers need to be more critical in their analysis of reports of the success and risks of IS outsourcing.

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This paper proposes a new model – the Information Systems Acceptance (ISA) model - to explain and predict IS acceptance. Drawing on previous literature, and the results of a series of case studies, the ISA model integrates four sets of factors influencing IS acceptance: (i) technology characteristics; (ii) management actions; (iii) service quality; and (iv) system use, user satisfaction and system outcomes. These sets of factors are drawn from well-established frameworks. Building on established theories, the model incorporates previous research, overcomes some of the limitations associated with these individual theories, and assembles IS acceptance factors into a comprehensive and useable conceptual framework.

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TCR repertoire diversity is important for the protective efficacy of CD8+ T cells, limiting viral escape and cross-reactivity between unrelated epitopes. The exact mechanism for selection of restricted versus diverse TCR repertoires is far from clear, although one thought is that the epitopes resembling self-peptides might select a limited array of TCR due to the deletion of autoreactive TCR. The molecule Aire promotes the expression of tissue-specific Ag on thymic medullary epithelial cells and the deletion of autoreactive cells, and in the absence of Aire autoreactive cells persist. However, the contribution of Aire-dependent peptides to the selection of the Ag-specific TCR repertoire remains unknown. In this study, we dissect restricted (DbNP366%+CD8+) and diverse (DbPA224%+CD8+, KdNP147%+CD8+) TCR repertoires responding to three influenza-derived peptides in Aire-deficient mice on both B6 and BALB/c backgrounds. Our study shows that the number, qualitative characteristics and TCR repertoires of all influenza-specific, DbNP366%+CD8+, DbPA224%+CD8+ and KdNP147%+CD8+ T cells are not significantly altered in the absence of Aire. This provides the first demonstration that the selection of an Ag-specific T-cell repertoire is not significantly perturbed in the absence of Aire.

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This paper asks why organisations invest in non-integrated CRM point solutions when many of the benefits of enterprise systems are claimed to be due to integration of processes and information. This paper identifies six factors that explain why organisations invest in CRM point solutions: reduced risk; lower cost; quick benefits realization; low integration ability, low interdependence of business units, and high business-unit differentiation. The evidence suggests that when interdependence between parts of an organization is low, possibly due to one unit producing a clearly differentiated product, the attractions of lower risk, lower cost, and/or faster access to the benefits are likely to induce organizations to adopt CRM point solutions. The contribution of this study is that it recognizes that, and explains why, it is not always optimal for organizations to adopt integrated CRM solutions.

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In the light of the currently increasing drought frequency and water scarcity on oceanic islands, it is crucial for the conservation of threatened insular vertebrates to assess how they will be affected. A 4000 yr old fossil assemblage in the Mare Aux Songes (MAS), southwest Mauritius, Mascarene Islands, contains bones of 100 000+ individual vertebrates, dominated by two species of giant tortoises Cylindraspis triserrata and C. inepta, the dodo Raphus cucullatus, and 20 other vertebrate species (Rijsdijk, Hume, Bunnik, Florens, Baider, Shapiro et al. (2009) Mid-Holocene vertebrate bone Concentration-Lagerstätte on oceanic island Mauritius provides a window into the ecosystem of the dodo (Raphus cucullatus). Quaternary Science Reviews 28: 14–24). Nine radiocarbon dates of bones statistically overlap and suggest mass mortality occurred between 4235 and 4100 cal. yr BP. The mortality period coincides with a widely recognized megadrought event. Our multidisciplinary investigations combining geological, paleontological and hydrological evidence suggests the lake was located in a dry coastal setting and had desiccated during this period. Oxygen isotope data from a Uranium-series dated stalagmite from Rodrigues, an island 560 km east of Mauritius, supports this scenario by showing frequently alternating dry and wet periods lasting for decades between 4122 and 2260 cal. yr BP. An extreme drought resulted in falling water-tables at MAS and elsewhere on the island, perhaps deprived these insular vertebrates of fresh water, which led to natural mass mortalities and possibly to extirpations. In spite of these events, all insular species survived until at least the seventeenth century, confirming their resistance to climatic extremes. Despite this, the generally exponential increase of combined human impacts on islands including loss of geodiversity, habitats, and stocks of fresh water, there will be less environmental safe-haven options for insular endemic and native vertebrates during future megadrought conditions; and therefore will be more prone to extinction.

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Lithographs have the following titles: Agnes River, Corner Inlet, Gipps Land -- West side of Mt Arapiles -- Mitchell River -- Mt. Munda from St. Hubert, Yering -- McAlister Valley, Gipps Land -- Wentworth River

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What would the Merleau-Ponty of Phenomenology of Perception have thought of the use of his phenomenology in the cognitive sciences? This question raises the issue of Merleau-Ponty’s conception of the relationship between the sciences and philosophy, and of what he took the philosophical significance of his phenomenology to be. In this article I suggest an answer to this question through a discussion of certain claims made in connection to the “post-cognitivist” approach to cognitive science by Hubert Dreyfus, Shaun Gallagher and Francisco Varela, Evan Thompson and Eleanor Rosch. I suggest that these claims are indicative of an appropriation of Merleau-Ponty’s thought that he would have welcomed as innovative science. Despite this, I argue that he would have viewed this use of his work as potentially occluding the full philosophical significance that he believed his phenomenological investigations to contain.