Diagonal ear lobe crease and atherosclerosis: a review of the medical literature and dental implications

In Spain a significant number of individuals die from atherosclerotic disease of the coronary and carotid arteries without having classic risk factors and prodromal symptoms. The diagonal ear lobe crease (DELC) has been characterized in the medical literature as a surrogate marker which can identify high risk patients having occult atherosclerosis. This topic however has not been examined in either the medical or dental literature emanating from Spain. The majority of clinical, angiography and postmortem reports support the premise that DELC is a valuable extravascular physical sign able to distinguish some patients at risk of succumbing to atherosclerosis of the coronary arteries. A minority of studies have however failed to support this hypothesis. More recently reports using B mode ultrasound have also linked DELC to atherosclerosis of the carotid artery and another report has related DELC to the presence of calcified carotid artery atheromas on panoramic radiographs. DELC is readily visible during head and neck cancer screening examinations. In conjunction with the patient"s medical history, vital signs, and panoramic radiograph, the DELC may assist in atherosclerotic risk assessment

Risk factors for colorectal cancer in subjects with family history of the disease.

The relationship between lifestyle factors, past medical conditions, daily meal frequency, diet and the risk of 'familial' colorectal cancer has been analysed using data from a case-control study conducted in northern Italy. A total of 1584 colorectal cancer patients and 2879 control subjects were admitted to a network of hospitals in the Greater Milan area and the Pordenone province. The subjects included for analysis were the 112 cases and the 108 control subjects who reported a family history of colorectal cancer in first-degree relatives. Colorectal cancer cases and control subjects with family history were similarly distributed according to sex, age, marital status, years of schooling and social class. Familial colorectal cancer was associated with meal frequency, medical history of diabetes (relative risk, RR = 4.6) and cholelithiasis (RR = 5.2). Significant positive trends of increasing risk with more frequent consumption were observed for pasta (RR = 2.5, for the highest vs the lowest intake tertile), pastries (RR = 2.4), red meat (RR = 2.9), canned meat (RR = 1.9), cheese (RR = 3.5) and butter (RR = 1.9). Significant inverse associations and trends in risk were observed for consumption of poultry (RR = 0.4), tomatoes (RR = 0.2), peppers (RR = 0.3) and lettuce (RR = 0.3). Significant inverse trends in risk with increasing consumption for beta-carotene and ascorbic acid were observed (RR = 0.5 and 0.4 respectively, highest vs lowest intake tertile). These results suggest that risk factors for subjects with a family history of colorectal cancer in first-degree relatives are not appreciably different from recognized risk factors of the disease in the general population.

Implementación de un esquema criptográfico para gestionar de forma segura los historiales médicos de los pacientes a través de una red de comunicaciones

L'objectiu és implementar un esquema criptogràfic que garanteixi les necessitats de seguretat d'un historial mèdic que pot ser gestionat a través d'una xarxa de comunicacions (per exemple tota una intranet d'un centre mèdic).

Implementació d'un esquema criptogràfic per gestionar de forma segura els historials mèdics dels pacients a través d'una xarxa de comunicacions

L'objectiu d'aquest projecte és implementar un esquema criptogràfic que garanteixi les necessitats de seguretat de les dades d'un historial mèdic el qual serà gestionat a través d'una xarxa de comunicacions convencionals.

Implementación de un esquema criptográfico para gestionar deforma segura las historias médicas de los pacientes a través de una red de comunicaciones

En aquest projecte de final de carrera s'ha dissenyat, implementat i provat un sistema que utilitzant criptografia de clau pública, garanteix la correcta utilització de les dades en un procés de consulta i complimentació d'una història clínica informatitzada consultada a distància.

PFC - seguretat informàtica : disseny i desenvolupament d'un esquema criptogràfic per gestionar de forma segura els historials mèdics dels pacients a través d'una xarxa de comunicacions

Es vol proporcionar una solució en el camp de la sanitat perquè els metges puguin gestionar els historials mèdics dels seus pacients de forma remota i segura, i perquè els pacients puguin consultar la seva història mèdica també remotament i amb total seguretat en qualsevol moment i ubicació.

Anàlisi dels aspectes mèdics de la mort violenta a Lleida a la Baixa Edat Mitjana: vol. 1

Aquest treball és el primer volum de la tesi presentada pel doctor Camps i Clemente, publicada pel Seminari Pere Mata per tal de donar-li major difusió. En aquesta tesi, l'autor estudia d'una forma extensa i profunda els episodis de mort violenta reportats a Lleida entre els anys 1308 i 1516. Els 342 procediments estudiats es guarden a la Paeria de Lleida i aporten dades sobre la realitat mèdico-sanitària i social de l'època baix-medieval.

Anàlisi dels aspectes mèdics de la mort violenta a Lleida a la Baixa Edat Mitjana: vol. 2

Aquí tenim el segon volum de la tesi del doctor Camps i Clemente sobre la mort violenta en el territori lleidatà durant els segles XIV i XV

Censura e Inquisición en las crónicas de Indias. De sus adversidades e infortunios

Desde su aparición hasta nuestros días, las crónicas de Indias han sufrido uncamino de infortunios. Entre los hechos que han contribuido a su escasa difusión,la falta de lectores o el poco reconocimiento, podemos destacar, en losprimeros siglos, la existencia del Tribunal Inquisitorial, las interferencias estatales en materia de Indias, la propia complejidad de las obras, las modas literarias, la rigidez de algún cura bien avenido con el poder, el temor a las copias y apropiaciones ilegales o las envidias y recelos entre los cronistas, ya fueran éstos laicos o religiosos (inquinas entre las órdenes). Asimismo, también las órdenes religiosas censuraban los documentos o textos de sus propios religiosos, cuando no encarcelaban a aquellos que sin su consentimiento habíanhecho públicas determinadas opiniones. Tal es el caso de «Motolinía», encarceladopor su propia orden, por haber escrito una Carta dirigida al emperador Carlos V contra Bartolomé de las Casas, sin previa autorización de sussuperiores...

Fray Toribio de Motolinía y la política colonial española: los Tributos y las leyes nuevas

La empresa providencial de la conquista y el recuerdo al buen caballeroy venturoso capitán, Hernando Cortés, conforman temáticamente la epístola proemial de la Historia de los indios de la Nueva España, de fray Toribio de Paredes, así como la historia de los pueblos precolombinos mexicas. Motolinía seguidamente pasará a arremeter contra los tributos que pesan sobre los indios. De esta manera, ya en el tratado primero, hará mención de las plagas que asolaron a las poblaciones amerindias tras la llegada de los españoles. A las tres primeras, la peste y el sarampión, las muertes ocasionadas por las guerras, y el hambre, llega la cuarta, esto es, la de los estancieros y negros que los conquistadores pusieron para cobrar los tributos. Así explica nuestro cronista el poder abusivo de tales hombres: «En los años primeros eran tan absolutos estos calpixques que en maltratar a los indios y en cargarlos y enviarlos lejos de su tierra y darles otros muchos trabajos, que muchos indios murieron por su causa y a sus manos, que es lo peor»...

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

BACKGROUND: Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective--their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd) (NCT01062607) aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. METHODS: WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices) in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales), adherence to treatment (DAI-10 scale and Medication Possession Ratio), quality of life (EQ-5D scale), healthcare resources, and caregiver burden (BAS scale) will be collected. Descriptive analysis with common statistics will be performed. DISCUSSION: This study will provide detailed descriptions of the management of BD in different countries, particularly in terms of clinical outcomes and resources used. Thus, it should provide psychiatrists with reliable and up-to-date information about those factors associated with different management patterns of BD. TRIAL REGISTRATION NO: ClinicalTrials.gov: NCT01062607.

Acerca de la denominada Crónica de Zaragoza.

La denominada Cronica Caesaraugustana o Crónica de Zaragoza, atribuida generalmente a Máximo, obispo de esta ciudad, es una fuente muy valiosa para el conocimiento de la España visigoda. Nos proporciona noticias acerca de acontecimientos cuya memoria habría caído en el olvido de no ser por ella. Otras veces constituye nuestra referencia para poder datar hechos que otros textos reproducen sin ningún tipo de ubicación cronológica. Esta importancia, realmente indiscutible, ha propiciado que los investigadores la consulten y la citen en múltiples ocasiones.

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

BACKGROUND: Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective--their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd) (NCT01062607) aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. METHODS: WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices) in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales), adherence to treatment (DAI-10 scale and Medication Possession Ratio), quality of life (EQ-5D scale), healthcare resources, and caregiver burden (BAS scale) will be collected. Descriptive analysis with common statistics will be performed. DISCUSSION: This study will provide detailed descriptions of the management of BD in different countries, particularly in terms of clinical outcomes and resources used. Thus, it should provide psychiatrists with reliable and up-to-date information about those factors associated with different management patterns of BD. TRIAL REGISTRATION NO: ClinicalTrials.gov: NCT01062607.

Characterization of clinical and electrocardiographic findings in a youth population

Resting 12-lead electrocardiogram (ECG) has been employed in the evaluation of young asymptomatic subjects to detect pre-existing heart diseases. Although the incorporation of routine ECG remains controversial, there is increasing evidence that cardiomyopathies and ion channelopathies show ECG changes as the initial manifestation. The causes of sudden cardiac death in young people show a significant geographical variation. We aim to determine the prevalence and spectrum of ECG findings in a youth population. Methodology: From May 2010 to April 2013, a total of 976 young secondary school students (mean age, 14 years; range, 13-15) underwent voluntary medical screening that included a resting 12-lead ECG and structured clinical survey. Subjects with abnormal ECG findings were classified into two groups: major ECG findings group, which fulfilled a pre-specified checklist to screen for principal structural and electrical cardiopathies, and minor ECG findings group showing other ECG changes. The major ECG findings group was referred for secondary diagnostic tests at a tertiary institution. Results: Of the 976 subjects screened, 252 (25.82%; CI95%, 23.17-28.66) had ECG findings. Of note, 17 (1.74%) had major findings and 235 (24.08%) had minor findings on ECG. The prevalence of cardiovascular pathology within the major ECG findings group was 35.29%. The prevalence of ECG abnormalities was significantly higher in males than in females (29% vs 20.9%, P<0.01). Conclusions: The prevalence of ECG findings in a youth population was 25.82%. There were significant gender differences. The inclusion of universal ECG screening, in addition to medical history, may increase the sensitivity of a cardiovascular screening program. Knowledge of the spectrum and prevalence of ECG findings and disease conditions would be pivotal in designing customized screening programs

Un curriculum vitae de Martín García de Mendoza dictat per ell mateix

En aquest article, s"hi presenta la transcripció de dos documents ja coneguts, però inèdits: el testament i la petició de ciutadania honrada de Martín García de Mendoza, mestre major de l"obra de la seu de Tortosa entre 1581 i 1615. La lectura d"aquests textos permet fer diverses precisions sobre la formació, les influències i les idees que l"arquitecte tenia sobre el seu ofici.