97 resultados para habitat natural
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Sociedade e Território - Enjeux sociaux et transformations du territoire, Nº Especial, Lisboa, p. 53-56
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Dissertação apresentada como requisito parcial para obtenção do grau de Mestre em Ciência e Sistemas de Informação Geográfica
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Dissertação apresentada à Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Mecânica
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The S100 proteins are 10-12 kDa EF-hand proteins that act as central regulators in a multitude of cellular processes including cell survival, proliferation, differentiation and motility. Consequently, many S100 proteins are implicated and display marked changes in their expression levels in many types of cancer, neurodegenerative disorders, inflammatory and autoimmune diseases. The structure and function of S100 proteins are modulated by metal ions via Ca2+ binding through EF-hand motifs and binding of Zn2+ and Cu2+ at additional sites, usually at the homodimer interfaces. Ca2+ binding modulates S100 conformational opening and thus promotes and affects the interaction with p53, the receptor for advanced glycation endproducts and Toll-like receptor 4, among many others. Structural plasticity also occurs at the quaternary level, where several S100 proteins self-assemble into multiple oligomeric states, many being functionally relevant. Recently, we have found that the S100A8/A9 proteins are involved in amyloidogenic processes in corpora amylacea of prostate cancer patients, and undergo metal-mediated amyloid oligomerization and fibrillation in vitro. Here we review the unique chemical and structural properties of S100 proteins that underlie the conformational changes resulting in their oligomerization upon metal ion binding and ultimately in functional control. The possibility that S100 proteins have intrinsic amyloid-forming capacity is also addressed, as well as the hypothesis that amyloid self-assemblies may, under particular physiological conditions, affect the S100 functions within the cellular milieu.
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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Antropologia - Área de especialização de Natureza e Conservação
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Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Gestão do Território – Ambiente e Recursos Naturais
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Dissertation submitted in partial fulfilment of the requirements for the Degree of Master of Science in Geospatial Technologies
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Dissertação para obtenção do grau de Mestre em Engenharia Civil – Perfil de Construção
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Dissertation presented to obtain the Ph.D. degree in Biology at the Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa.
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Dissertation to obtain a Master Degree in Biotechnology
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Dissertation to obtain a Master Degree in Biotechnology
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Dissertação para obtenção do Grau de Mestre em Engenharia do Ambiente, perfil em Gestão e Sistemas Ambientais
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Dissertação para obtenção do Grau de Mestre em Engenharia do Ambiente, perfil de Gestão e Sistemas Ambientais
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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Gestão do Território
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More than 65% (1040 species) of arthropod species alien to Europe are associated with human-made habitats, especially parks and gardens, human settlements and agricultural lands, whereas woodlands are yet colonized by less than 20% of the alien fauna, which still has a negligible representation in the other natural and semi-natural habitats. Large diff erences in habitat affi nity are observed between alien taxonomic groups. Phytophagous species are predominant among aliens, representing 47.2% of species alien to Europe.