Optimiza����o dos protocolos de reconstru����o em imagens TC de AVC isqu��mico agudo: projecto

Mestrado de Radia����es aplicadas ��s Tecnologias da Sa��de. ��rea de especializa����o: Imagem Digital com Radia����o X.

CVD of CrO2 thin films: Influence of the deposition parameters on their structural and magnetic properties

This work reports on the synthesis of CrO2 thin films by atmospheric pressure CVD using chromium trioxide (CrO3) and oxygen. Highly oriented (100) CrO2 films containing highly oriented (0001) Cr2O3 were grown onto Al2O3(0001) substrates. Films display a sharp magnetic transition at 375 K and a saturation magnetization of 1.92 mu(B)/f.u., close to the bulk value of 2 mu(B)/f.u. for the CrO2.

Valida����o da efic��cia dos procedimentos de limpeza, no equipamento de fabrico e embalagem, na ind��stria farmac��utica

Na ind��stria farmac��utica, a limpeza dos equipamentos e superf��cies �� muito importante no processo de fabrico/embalagem dos produtos farmac��uticos. Poss��veis res��duos contaminantes devem ser removidos dos equipamentos e das superf��cies envolvidas no processo. De acordo com as Boas Pr��ticas de Fabrico (GMP), os procedimentos de limpeza e os m��todos anal��ticos usados para determinar as quantidades de res��duos devem ser validados. O m��todo anal��tico combinado com o m��todo de amostragem utilizado na colheita de amostras deve ser sujeito a um ensaio de ���recovery���. Neste trabalho apresenta-se uma estrat��gia inovadora para a valida����o de limpeza de formas farmac��uticas semi-s��lidas. Prop��e-se o uso de um m��todo de amostragem que consiste na colheita direta de amostra ap��s o seu fabrico, sendo a an��lise de res��duos feita directamente nesta amostra. Os produtos escolhidos para a avalia����o da estrat��gia foram dois medicamentos dermatol��gicos, apresentados na forma de pomada e produzidos numa unidade de fabrico de v��rios produtos, pela Schering Plough Farma/ Merck Sharp & Dohme (Cac��m, Portugal). Como m��todos anal��ticos para a quantifica����o dos res��duos, utilizaram-se m��todos validados por via espectrofotom��trica (HPLC), usados na an��lise do produto acabado. A valida����o de limpeza foi avaliada atrav��s da an��lise de uma quantidade conhecida de pomada (produto B (*)), usando o m��todo de an��lise da pomada fabricada anteriormente (produto A (*)), de modo a verificar-se a exist��ncia ou n��o de agente de limpeza e subst��ncias ativas deixadas ap��s a limpeza do produto A, e vice-versa. As concentra����es residuais das subst��ncias ativas e do agente de limpeza encontradas ap��s a limpeza foram nulas, ou seja, inferiores ao limite de dete����o (LOD), sendo que o crit��rio de aceita����o da limpeza utilizado foi de 6,4 x 10-4 mg/g para a subst��ncia ativa 1 (*); 1,0 x 10-2 mg/g para a subst��ncia ativa 2 (*); 1,0 x 10-3 mg/g para a subst��ncia ativa 3 (*) e de 10 ppm para o agente de limpeza. No ensaio de ���recovery���, obtiveram-se resultados acima de 70% para todas as subst��ncias ativas e para o agente de limpeza nas duas pomadas. Antes de se proceder a este ensaio de ���recovery���, houve a necessidade de ajustar as condi����es cromatogr��ficas dos m��todos anal��ticos de ambos os produtos e do agente de limpeza, por forma a obter-se valores da conformidade do sistema (fator de tailling e de resolu����o) de acordo com as especifica����es. A precis��o dos resultados, reportada como desvio padr��o relativo (RSD), deu abaixo de 2,0%, excepto nos ensaios que envolvem a subst��ncia ativa 3, cuja especifica����o �� inferior a 10,0%. Os resultados obtidos demonstraram que os procedimentos de limpeza usados na unidade de fabrico em causa s��o eficazes, eliminando assim a exist��ncia de contamina����o cruzada.

a-SiH p-i-n structures with extreme i-layer thickness

We present measurements and numerical simulation of a-Si:H p-i-n detectors with a wide range of intrinsic layer thickness between 2 and 10 pm. Such a large active layer thickness is required in applications like elementary particle detectors or X-ray detectors. For large thickness and depending on the applied bias, we observe a sharp peak in the spectral response in the red region near 700 nm. Simulation results obtained with the program ASCA are in agreement with the measurement and permit the explanation of the experimental data. In thick samples holes recombine or are trapped before reaching the contacts, and the conduction mechanism is fully electron dominated. As a consequence, the peak position in the spectral response is located near the optical band gap of the a-Si:H i-layer. (C) 2009 Elsevier B.V. All rights reserved.

Concorr��ncia fiscal prejudicial

Mestrado em Fiscalidade

O justo valor como base de mensura����o e sua auditoria: o caso particular dos fundos de investimento imobili��rios fechados

Mestrado em Auditoria

A class of singular first order differential equations with applications in reaction-diffusion

Ag��ncias Financiadoras: FCT e MIUR

Longe da vista, longe do cora����o: o design como �����ncora��� visual e elemento agregador da atividade museol��gica

To become an open to outer space, the "museum" acquired new forms and new expressions. The complexity of museological activity thus leads to new representations that alter the initial image of the museum as a building with objects. Their 'boundaries' are now less sharp, not only in relation to the spatial relationship, but also to its temporal dimension, creating an additional challenge which is the recognition of the museum itself. The design, while transdisciplinary activity, thereby assumes a key role in the communication of the museums in its visual representation and recognition of their action. The present study results from a survey conducted in 2010 to 364 Portuguese museums (from a universe of 849 museums), presenting an analysis to its base elements of visual expression of identity (name, logo, symbol, and color).

Climatology of the Iberia coastal low-level wind jet: weather research forecasting model high-resolution results

Coastal low-level jets (CLLJ) are a low-tropospheric wind feature driven by the pressure gradient produced by a sharp contrast between high temperatures over land and lower temperatures over the sea. This contrast between the cold ocean and the warm land in the summer is intensified by the impact of the coastal parallel winds on the ocean generating upwelling currents, sharpening the temperature gradient close to the coast and giving rise to strong baroclinic structures at the coast. During summertime, the Iberian Peninsula is often under the effect of the Azores High and of a thermal low pressure system inland, leading to a seasonal wind, in the west coast, called the Nortada (northerly wind). This study presents a regional climatology of the CLLJ off the west coast of the Iberian Peninsula, based on a 9km resolution downscaling dataset, produced using the Weather Research and Forecasting (WRF) mesoscale model, forced by 19 years of ERA-Interim reanalysis (1989-2007). The simulation results show that the jet hourly frequency of occurrence in the summer is above 30% and decreases to about 10% during spring and autumn. The monthly frequencies of occurrence can reach higher values, around 40% in summer months, and reveal large inter-annual variability in all three seasons. In the summer, at a daily base, the CLLJ is present in almost 70% of the days. The CLLJ wind direction is mostly from north-northeasterly and occurs more persistently in three areas where the interaction of the jet flow with local capes and headlands is more pronounced. The coastal jets in this area occur at heights between 300 and 400 m, and its speed has a mean around 15 m/s, reaching maximum speeds of 25 m/s.

Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells

Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Reply to "Comment on 'Effect of polydispersity on the ordering transition of adsorbed self- assembled rigid rods'"

We comment on the nature of the ordering transition of a model of equilibrium polydisperse rigid rods on the square lattice, which is reported by Lopez et al. to exhibit random percolation criticality in the canonical ensemble, in sharp contrast to (i) our results of Ising criticality for the same model in the grand canonical ensemble [Phys. Rev. E 82, 061117 (2010)] and (ii) the absence of exponent(s) renormalization for constrained systems with logarithmic specific-heat anomalies predicted on very general grounds by Fisher [Phys. Rev. 176, 257 (1968)].

Ambient noise tomography of the East African Rift in Mozambique

Seismic ambient noise tomography is applied to central and southern Mozambique, located in the tip of the East African Rift (EAR). The deployment of MOZART seismic network, with a total of 30 broad-band stations continuously recording for 26 months, allowed us to carry out the first tomographic study of the crust under this region, which until now remained largely unexplored at this scale. From cross-correlations extracted from coherent noise we obtained Rayleigh wave group velocity dispersion curves for the period range 5���40 s. These dispersion relations were inverted to produce group velocity maps, and 1-D shear wave velocity profiles at selected points. High group velocities are observed at all periods on the eastern edge of the Kaapvaal and Zimbabwe cratons, in agreement with the findings of previous studies. Further east, a pronounced slow anomaly is observed in central and southern Mozambique, where the rifting between southern Africa and Antarctica created a passive margin in the Mesozoic, and further rifting is currently happening as a result of the southward propagation of the EAR. In this study, we also addressed the question concerning the nature of the crust (continental versus oceanic) in the Mozambique Coastal Plains (MCP), still in debate. Our data do not support previous suggestions that the MCP are floored by oceanic crust since a shallow Moho could not be detected, and we discuss an alternative explanation for its ocean-like magnetic signature. Our velocity maps suggest that the crystalline basement of the Zimbabwe craton may extend further east well into Mozambique underneath the sediment cover, contrary to what is usually assumed, while further south the Kaapval craton passes into slow rifted crust at the Lebombo monocline as expected. The sharp passage from fast crust to slow crust on the northern part of the study area coincides with the seismically active NNE-SSW Urema rift, while further south the Mazenga graben adopts an N-S direction parallel to the eastern limit of the Kaapvaal craton. We conclude that these two extensional structures herald the southward continuation of the EAR, and infer a structural control of the transition between the two types of crust on the ongoing deformation.