Da cenografia como laboratório de todas as artes: Jos�� Manuel Castanheira

Este �� o primeiro texto cr��tico sobre a obra cenogr��fica de Jos�� Manuel Castanheira at�� 2001.

Development of TNBS-induced colitis: animal model to test new pharmacological approaches

IBD is a gastro-intestinal disorder marked with chronic inflammation of intestinal epithelium, damaging mucosal tissue and manifests into several intestinal and extra-intestinal symptoms. Currently used medical therapy is able to induce and maintain the patient in remission, however no modifies or reverses the underlying pathogenic mechanism. The research of other medical approaches is crucial to the treatment of IBD and, for this, it��s important to use animal models to mimic the characteristics of disease in real life. The aim of the study is to develop an animal model of TNBS-induced colitis to test new pharmacological approaches. TNBS was instilled intracolonic single dose as described by Morris et al. It was administered 2,5% TNBS in 50% ethanol through a catheter carefully inserted into the colon. Mice were kept in a Tredelenburg position to avoid reflux. On day 4 and 7, the animals were sacrificed by cervical dislocation. The induction was confirmed based on clinical symptoms/signs, ALP determination and histopathological analysis. At day 4, TNBS group presented a decreased body weight and an alteration of intestinal motility characterized by diarrhea, severe edema of the anus and moderate morbidity, while in the two control groups weren���t identified any alteration on the clinical symptoms/signs with an increase of the body weight. TNBS group presented the highest concentrations of ALP comparing with control groups. The histopathology analysis revealed severe necrosis of the mucosa with widespread necrosis of the intestinal glands. Severe hemorrhagic and purulent exsudates were observed in the submucosa, muscular and serosa. TNBS group presented clinical symptoms/signs and histopathological features compatible with a correct induction of UC. The peak of manifestations became maximal at day 4 after induction. This study allows concluding that it���s possible to develop a TNBS induced colitis 4 days after instillation.

Phisiodata: desenvolvimento da evid��ncia cient��fica da fisioterapia em Portugal

Mestrado em Fisioterapia

Estudo da compactabilidade em laboratório de misturas betuminosas com res��duos pl��sticos

Disserta����o para obten����o do grau de Mestre em Engenharia Civil na ��rea de Especializa����o em Vias de Comunica����o e Transportes

Laboratório de cria����o a partir de Macbeth de William Shakespeare: relat��rio de est��gio

Relat��rio de Est��gio submetido �� Escola Superior de Teatro e Cinema para cumprimento dos requisitos necess��rios �� obten����o do grau de Mestre em Teatro - especializa����o em Encena����o.

Projeto de conceito e estrutura de website para o combate ao abandono animal em Portugal

Trabalho de projeto apresentado �� Escola Superior de Comunica����o Social como parte dos requisitos para obten����o de grau de mestre em Publicidade e Marketing.