14 resultados para New Knowledge
em Universidade do Minho
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Relatório de estágio de mestrado em Educação Pré-Escolar e Ensino do 1.º do Ensino Básico
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Relatório de estágio de mestrado em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico
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Tese de Doutoramento em Ciências da Educação - Especialidade de Desenvolvimento Curricular
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Tese de Doutoramento Ramo Engenharia Industrial e de Sistemas
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Tese de Doutoramento em Tecnologias e Sistemas de Informação
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A intervenção aqui descrita teve como objetivo contribuir para o envelhecimento ativo de usuários de centros-dia/convívio para idosos, desenvolvendo harmoniosamente todas suas dimensões, visando que os utentes fossem autônomos, participativos e ativos. Recorrendo ao paradigma interpretativo-hermenêutico, apoiamo-nos num trabalho de investigação-ação participativa, construído e implementado em dois centros-dia/convívio do conselho da Póvoa de Lanhoso, distrito de Braga, Portugal, e que contou com um total de 25 usuários: 12 no centro de convívio A e 13 no centro de convívio B. O objetivo foi transversal a todas as atividades implementadas, tendo sido alcançado como revelam os resultados satisfatórios obtidos na avaliação da intervenção (e de cada uma das atividades). A avaliação contínua e final permitiu, igualmente, aferir que todas as atividades desenvolvidas foram do agrado dos usuários e que todas lhes possibilitaram novos conhecimentos que os ajudaram na sua vida diária, aumentando, consequentemente, sua qualidade de vida e tornando-os mais autônomos, participativos e ativos.
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Dissertação de mestrado em Engenharia Industrial
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Dissertação de mestrado em Ciências da Educação (área de especialização em Sociologia da Educação e Políticas Educativas)
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The authors thank the federal agency CAPES and the Foundation for Research Support of the state of Sao Paulo, Brazil (FAPESP) for providing a PhD scholarship, and the University of Minho, in Portugal, for the international collaboration.
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The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information is needed concerning the rock mass which can be difficult to obtain in some projects or project stages at least with accuracy. In 2007 an alternative classification scheme based on the RMR, the Hierarchical Rock Mass Rating (HRMR) was presented. The main feature of this system was the adaptation to the level of knowledge existent about the rock mass to obtain the classification of the rock mass since it followed a decision tree approach. However, the HRMR was only valid for hard rock granites with low fracturing degrees. In this work, the database was enlarged with approximately 40% more cases considering other types of granite rock masses including weathered granites and based on this increased database the system was updated. Granite formations existent in the north of Portugal including Porto city are predominantly granites. Some years ago a light rail infrastructure was built in the city of Porto and surrounding municipalities whi h involved considerable challenges due to the high heterogeneity levels of the granite formations and the difficulties involved in their geomechanical characterization. In this work it is intended to provide also a contribution to improve the characterization of these formations with special emphasis to the weathered horizons. A specific subsystem applicable to the weathered formations was developed. The results of the validation of these systems are presented and show acceptable performances in identifying the correct class using less information than with the RMR system.
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[Excerpt] Purine nucleobases are fundamental biochemicals in living organisms. They have been a valuable inspiration for drug design once they play several key roles in the cell.1 To the best of our knowledge, reported routes to 8-aminopurines are still scarce due to the difficulty in introducing amino groups in this position of the purine ring. Here we report a novel, inexpensive and facile synthetic method to generate N3,N6-disubstituted-6,8-diaminopurines. In our research group, a number of substituted purines have been obtained from a common imidazole precursor, the 5-amino-4-cyanoformimidoyl imidazole 1. Recently, a comprehensive study on the reactivity of imidazoles 1 with nucleophiles under acidic conditions led us to develop experimental methods to incorporate primary amines into the cyanoformimidoyl group.2 (...)
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[Excerpt] Purine nucleobases are essential biomolecules in living organisms. Playing several key roles in the cell, they have been a significant inspiration for drug design.1 Benzimidazole nucleus is an important pharmacophore in the development of molecules with pharmaceutical or biological interest. Benzimidazoles have been reported to display significant pharmacological activities such as antiulcer, antifungal, antiparkinson, anticancer and antibiotic.2 Fused structures incorporating these two scaffolds might be important for medicinal chemistry and, to the best of our knowledge, there are no reports of these systems in the literature. In particular, benzo[4,5]imidazo[2,1]purines seem to be novel and must be important target molecules in the heterocyclic synthesis. (...)
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Tese de Doutoramento em Ciências da Saúde
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Tese de Doutoramento em Ciências (área de especialização em Química)