Evolution of the tandem repeats in thymidylate synthase enhancer region (TSER) in primates

The upstream regulatory region of the human thymidylate synthase gene (thymidylate synthase enhancer region, TSER) is length polymorphic, attributable to variable numbers of tandemly repeated copies of a 28-bp fragment. It has been found that TSER length

Semi-gas kinetics model for performance modeling of flowing chemical oxygen-iodine lasers (COIL)

A semi-gas kinetics (SGK) model for performance analyses of flowing chemical oxygen-iodine laser (COIL) is presented. In this model, the oxygen-iodine reaction gas flow is treated as a continuous medium, and the effect of thermal motions of particles of different laser energy levels on the performances of the COIL is included and the velocity distribution function equations are solved by using the double-parameter perturbational method. For a premixed flow, effects of different chemical reaction systems, different gain saturation models and temperature, pressure, yield of excited oxygen, iodine concentration and frequency-shift on the performances of the COIL are computed, and the calculated output power agrees well with the experimental data. The results indicate that the power extraction of the SGK model considering 21 reactions is close to those when only the reversible pumping reaction is considered, while different gain saturation models and adjustable parameters greatly affect the output power, the optimal threshold gain range, and the length of power extraction.

TiC原位增强块状Cu_(47)Ti_(34)Zr_(11)Ni_8非晶合金复合材料

在电弧炉中利用吸铸法制备了直径1-4 mm的原位生成TiC和β-Ti枝晶联合增强的块状Cu47Ti34Zr11Ni8非晶合金复合材料.DSC热分析结果表明,原位生成TiC颗粒的引入,没有影响基体合金的非晶形成能力.用OM,XRD,SEM,EDS等方法研究了复合材料的相组成、微观组织以及成分分布,结果表明,TiC颗粒作为异质形核中心促进了β-Ti枝晶的形成,形成了TiC颗粒和β-Ti枝晶联合增强的块状Cu47Ti34Zr11Ni8非晶合金复合材料,而且β-Ti枝晶的尺寸和数量与TiC颗粒的多少以及试样的尺寸有关.室温压缩试验表明,同单相非晶合金相比,块状Cu47Ti34Zr11Ni8非晶合金复合材料提高了抗压强度及塑性.

47,XY,+dcl(9)(q34)wcp(9+)/46,XY伴隐睾一例

患儿男,10岁,因"双侧隐睾"就诊.患儿系足月、顺产、5岁时发现头颅大,经医院诊断为脑积水.几岁时做双侧隐睾手术.患儿身高120 cm.头颅发育不规则,颜面不对称,自小严重的智力低下,说话不清.

江汉平原47号钻孔中的化石硅藻及其在古环境分析上的意义

江汉平原47号钻孔,位于湖北省江汉平原的江陵县,在其上段的46.6-2.2m层位上,有丰富的化石硅藻,约有26属148种,其中绝大多数是现存的淡水种类,并以附生性、沿岸带和浅水性的种类为主。种类较多的属有:Navicula(28种)、Cymbella(23种)、Achnanthes(15种)、Gomphonema(14种)和Eunotia(13种)。主要种类有Gomphonema tropicale var. nonpunctatum、Cyclotella comta、Cocconeis placemul

江汉平原47号钻孔中化石硅藻的新种类

在江汉平原47号钻孔中的46.60—2.20m层位上(上更新统到全新统),含有丰富的化石硅藻,经鉴定有4个新种类,即Cymbella jianghanensis sp.nov.,C.tenuistriata sp.nov.,C.cistula(Hempr.) Grun.var.retcta var.nov.,Gomphonema tropicale Brun var.nonpunctatum var.nov..同时,对一个变种进行了重新命名和特征修改,即Eunotia clevei Grun.var.ob

In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As量子阱中的正磁电阻效应

在低温强磁场条件下,对In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As量子阱中的二维电子气进行了磁输运测试.在低磁场范围内观察到正磁电阻效应,在高磁场下这一正磁电阻趋于饱和,分析表明这一现象与二维电子气中的电子占据两个子带有关.在考虑了两个子带之间的散射效应后,通过分析低磁场下的正磁电阻,得到了每个子带电子的迁移率,结果表明第二子带电子的迁移率高于第一子带电子的迁移率.进一步分析表明,这主要是由两个子带之间的散射引起的.

两个子带占据的In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As量子阱中填充因子的变化规律

研究了低温(1.5K)和强磁场(0-13T)条件下,InP基In_(0.53)Ga_(0.47)As/In_(0.52)A_(l0.48)As量子阱中电子占据两个子带时填充因子随磁场的变化规律.结果表明,在电子自旋分裂能远小于朗道能级展宽的情况下,如果两个子带分裂能是朗道分裂能的整数倍时,即⊿E_(21)=κ*ω_c(其中κ为整数),填充因子为偶数;当两个子带分裂能为朗道分裂能的半奇数倍时,即⊿E_(21)=(2κ+1*ω/2,填充因子出现奇数.

In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As量子阱中双子带占据的二维电子气的输运特性

研究了不同沟道厚度的In_(0.53) Ga_(0.47)As/In_(0.52)Al_(0.48)As量子阱中双子带占据的二维电子气的输运特性.在考虑了两个子带电子之间的磁致子带间散射效应后,通过分析Shubnikov-de Haas振荡一阶微分的快速傅里叶变换结果,获得了每个子带电子的浓度、输运散射时间、量子散射时间以及子带之间的散射时间.结果表明,对于所研究的样品,第一子带电子受到的小角散射更强,这与第一子带电子受到了更强的电离杂质散射有关.

匹配In（0.53）Ga（0.47）As/InP量子阱材料的GSMBE生长及特性分析

于2010-11-23批量导入

五种毛壳霉属和曲霉属真菌代谢产物及细胞毒活性

毛壳霉属(Chaetomium)和曲霉属(Aspergillus)真菌产生多种具有生物活性的化合物。为系统阐明两属微生物的次生代谢物，对三种毛壳霉、两种曲霉真菌分别进行固态发酵，以色谱和波谱技术研究发酵物中的成分，分离鉴定了51个化合物，其中23个为新化合物，测试了部分化合物对肿瘤细胞的活性。 1、从螺卷毛壳霉（C. cochloides）固态发酵物中分离鉴定了11个化合物，3个新化合物为螺卷毛壳霉素A~C（1~3）。化合物1、3及dethio-tetra (methylthio) chetomin（4）对Bre-04、Lu-04和N-04细胞株生长抑制的GI50值为0.05~7.0 μg/mL。 2、从印度毛壳霉（C. indicum）固态发酵物中鉴定的三个异喹啉生物碱印度毛壳霉素A~C（12~14）代表两类骨架新颖的异喹啉生物碱。 3、从巴西毛壳霉（C. brasiliense）固态发酵物中鉴定了11个化合物，其中Mollicellins I~J（15~16）、2-Hydroxymethyl-6-methylmethyleugenin（19）为新化合物。化合物16和Mollicellin H（18）对Bre-04、Lu-04、N-04细胞株生长抑制的GI50值在2.5~8.6 μg/mL。 4、从土曲霉（A. terreus）固态发酵物中鉴定了18个化合物。5个为新化合物为Terretonin A~D（24~27）和Asterrelenin（28），24~27为二倍半萜化合物，28为吲哚生物碱。 5、从杂色曲霉(A. versicolor）固态发酵物中鉴定了16个化合物。9个新的化合物Brevianamides K~N (40~43)、Averins A~C (44~46)和Glyanphenines A~B (47~48)代表三种类型的生物碱。 6、综述了1997－2007年间新的二倍半萜的研究进展。 The fungi of the genera Chaetomium and Aspergillus produce various secondary metabolites with biological activities. In order to systematically study the secondary metabolites, the solid-state fermented rice culture of three species of Chaetomium and two of Aspergillus were chemically studied. By the means of chromatograhy and spectroscopy, 55 compounds were isolated and identified, among of them 23 were new ones. The biological activities of some compounds were investigated. 1. From the fungus C. cochliodes, three new epipolythiodioxopiperazines, chaetocochins A-C (1-3) were isolated, together with 8 known ones (4-11). Compounds 1, 3 and 4 showed growth inhibitory effects against cancer cell lines Bre-04, Lu-04 and N-04 with GI50 values from 0.05 to 7.0 μg/mL. 2. Three novel isoquinolines Chaetoindicins A-C (12-14) were isolated and identified from the fungus C. indicum. Chaetoindicin A, Chaetoindicins B-C represented two classes of novel carbon skeletons. 3. Three new compounds, Mollicellins I-J (15-16), and 2-hydroxymethyl-6-methylmethyleugenin (19), were isolated from C. brasiliense. Compound 16 and Mollicellin H (18) showed growth inhibitory effects against cancer cell lines Bre-04, Lu-04 and N-04 with GI50 values from 2.5 to 8.6 μg/mL. 4. Eighteen compounds were isolated from the fungus A. terreus. Terretonin A-D（24 - 27）and Asterrelenin（28） are new compounds belonging to sesterterpoids and indole-ralated alkaloid, respectively. 5. From the fungus A. versicolor, sixteen secondary metabolites, including nine new ones, Brevianamides K-N (40-43), Averins A-C (44-46), and Glyanphenines A-B (47-48), were isolated and identified. Brevianamides K-N (40-43), Averins A-C (44-46), and Glyanphenines A-B (47-48) represented three classes of alkaloids. 6. New sesterterpenes and their bioactivities reported from 1997 to 2007 were summarized.

47 MeV/u ~(12)C与~(133)Cs反应中碘同位素产生截面的Q_(gg)依赖关系

用47 MeV/u 12C离子轰击133Cs靶,应用放射化学分离技术和离线γ射线谱学,得到碘同位素的产生截面。丰中子碘同位素的独立产生截面指数地依赖于Qgg值,而缺中子碘同位素的独立产生截面则偏离这一直线关系。这一事实可对在深部非弹转移过程中产生丰中子碘同位素予以解释。

Quasi-Elastic Scattering of C-16 from C-12 at 47.5 MeV/Nucleon

Differential cross sections for the quasi-elastic scattering of C-16 at 47.5 MeV/nucleon from C-12 target are measured. Coupled-channels calculations are carried out and the optical potential parameters are obtained by fitting the experimental angular distribution.