145 resultados para Stammzelltransplantation, Leukämie, Alloreaktivität, HLA-Moleküle, Mismatch


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We present a study on the facet damage profile of quantum cascade lasers (QCLs). Conspicuous cascade half-loop damage strips on front facet are observed when QCLs catastrophically failed. Due to the large difference on thermal conductivities between active region and the substrate, dominant heat is compulsively driven to the substrate. Abundant heat accumulation and dissipation on substrate build large temperature gradient and thermal lattice mismatch. Thermal-induced stress due to sequential mismatch leads to the occurrence of the multistep damages on front facet. Good agreement is achieved between the observed locations of damaged strips and the calculated results.

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目前分布式体系结构的研究重点是提高系统的可扩展性、互操作性和可重用性,而对于实时性要求高的分布式仿真系统,还需要在HLA体系结构基础上,考虑如何提高系统的数据传输效率,以满足实时性要求。本文从应用层角度出发,从以下两个方面研究了改进策略: 一,从数据交互方面考虑,为了提高分布式仿真系统内部有效数据传输效率,满足系统实时性要求,以车辆定位仿真系统为问题原型,提出一种基于运行时间支撑系统数据分发管理(RTI-DDM)和套接字(Socket)的双层数据传输模型:一方面利用RTI-DDM来限定传输数据的范围,依据待交互的数据值域对数据的发送和接收进行过滤,有效降低系统内部冗余数据的传输;另一方面,利用Socket技术在仿真实体之间建立点对点的直接传输,从而提高系统的运行效率。对比实验结果表明,在相同的仿真交互数据量下,该模型相对于传统单层RTI数据传输模型,数据传输延时平均缩短70%。 二,从时间管理方面考虑,本文通过实验验证的方法,分析不同时间管理策略对仿真系统的数据传输和运行控制的影响,并针对车辆定位仿真系统中联邦成员之间的数据交互和逻辑控制关系特点,选择合适的时间管理策略,保证数据因果关系的正确性,进一步提高了系统的数据传输性能。 实验和应用结果表明,本文提出的改进策略简单有效,提高了系统数据传输效率,较好的解决了基于HLA/RTI的定位仿真系统的实时性问题。

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卫星移动通信作为下一代移动通信中一个必不可少的组成部分,用户接入切换和路由选择策略已经成为卫星移动通信领域的研究重点。同时对卫星通信网络建设方案及其关键技术进行充分的仿真建模论证也已经成为卫星通信系统建设前的一项必不可少的工作。本文围绕用户接入切换策略和路由选择策略开展了如下工作: 在卫星通信网络用户接入切换策略中,本文针对低轨卫星通信网络研究多星覆盖接入切换技术。首先在引入非均匀多业务模型的基础上,结合星上信道分配策略设计一种多业务组合加权接入策略。接着在基于HLA/RTI的卫星网络仿真系统之上进行用户接入仿真实现,并对最近卫星、最长覆盖时间和组合加权接入策略进行了仿真分析与比较,验证了组合加权策略下的系统性能。最后进一步仿真讨论加权系数取值不同对系统新呼叫阻塞概率、切换呼叫阻塞概率和切换请求到达概率的影响。 针对卫星通信网络路由策略,本文重点研究多层卫星网络,在建立星间链路预测模型的基础上,借鉴延时可容忍网络路由设计思想,设计一种链路中断容忍路由策略,利用非均匀时间段内卫星网络拓扑结构的可预测性进行路由表计算,同时提供动态的拥塞控制机制和基于洪范思想的故障中断容忍策略,解决由卫星运动、通信设备故障等引发链路中断情况下的路由问题。通过仿真,验证该路由策略的时空特性和链路利用率。

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根据坦克部队作战特点,以计算机技术、网络技术、系统仿真与模型方法为基础,将HLA与坦克分队战术训练相结合,把分散在不同地点的人与设备“连接”到同一模拟训练环境中;将虚拟现实技术与半实物仿真模拟器相结合,建立吴有时空一致性的系统合成的虚拟“战场环境”;将刚体运动学与解析几何相结合,解决坦克实体模型视景仿真和坦克直线运动与转向运动中的六自由度刚体运动学模拟技术。遵循这一技术路线,完成了以计算机仿真技术与军事训练专业的复合应用为目的的分布式坦克训练模拟与分析系统。

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Ultra-broadband optical parametric chirped-pulse amplification is analyzed based the compensation of phase-mismatch, which is achieved by matching of both group-velocity and pulse-front between signal and idler by the combination of the noncollinear-phase-match and pulse-front-tilt. The results show exactly matching of both group-velocity and pulse-front is the important criterion for constructing an UBOPCPA. Its general model is developed, in which the group velocities, noncollinear angles. spatial walk-off angles, linear angular spectral dispersion coefficients and pulse-front tilted angles are suitably linked to each other. Finally, specific numerical calculations and simulations are presented for beta-barium borate OPCPA with type-1 noncollinear angularly dispersed geometry. (C) 2005 Elsevier B.V. All rights reserved.

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The spectral bandwidth of three-wave-mixing optical parametric amplification has been investigated. A general mathematical model for evaluating the spectral bandwidth of optical parametric amplification is developed with parametric bandwidth and gain bandwidth via three-wave noncollinear interactions. The spectral bandwidth is determined by expanding the wave-vector mismatch in a Taylor series and retaining terms through second order. The model takes into account the effects of crystal length, noncollinear angle, group velocity, group-velocity dispersion and gain coefficient. The relation between parametric bandwidth and gain bandwidth is clearly defined. The model is applied to a BBO OPA, a LBO OPA and a CLBO OPA.

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The analysis and calculation of the compensation for the phase mismatch of the frequency-doubling using the frequency space chirp introduced from prisms are made. The result shows that suitable lens can compensate the phase mismatch in a certain extent resulting from wide femtosecond spectrum when the spectrum is space chirped. By means of this method, the experiment of second harmonic generation is carried out using a home-made femtosecond KLM Ti:sapphire laser and BBO crystal. The conversion efficiency of SHG is 63 %. The average output power of blue light is 320 mW. The central wavelength is 420 nm. The spectrum bandwidth is 5.5 nm. It can sustain the pulse width of 33.6 fs. The tuning range of blue light is 404-420 nm,when the femtosecond Ti:sapphire optical pulse is tuned using the prisms in the cavity.

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Low pressure metalorganic chemical vapour deposition (LP-MOCVD) growth and characteristics of InAssb on (100) Gasb substrates are investigated. Mirror-like surfaces with a minimum lattice mismatch are obtained. The samples are studied by photoluminescence spectra, and the output is 3.17 mu m in wavelength. The surface of InAssb epilayer shows that its morphological feature is dependent on buffer layer. With an InAs buffer layer used, the best surface is obtained. The InAssb film shows to be of n-type conduction with an electron concentration of 8.52 x 10(16) cm(-3).

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澜沧江姬鼠(Apodemus ilex)为小型啮齿类动物,长期以来常被认为是中华姬鼠(A. draco)或长尾姬鼠(A. orestes)的同物异名,但近年基于线粒体Cyt b 的研究证明,该类群与中华姬鼠的遗传距离达到了种间水平,并被认为是一个独立种。本文提取、扩增并测定了来自云南14个地区42个产地156个澜沧江姬鼠的Cyt b 全序列,并将GenBank中的3条澜沧江姬鼠的Cyt b 全序列纳入分析,选取福建武夷山与四川峨眉山的2个中华姬鼠样品的Cyt b 全序列,以及台湾姬鼠、大耳姬鼠、高山姬鼠Cyt b 全序列作为外群,利用贝叶斯法和最大似然法构建系统发育树,并使用Network分析,分子变异分析(AMOVA)分析、错配分析(Mismatch analysis)与Fu`Fs检验等方法,探讨了这些地区澜沧江姬鼠的种群遗传结构,种群动态及生物地理格局。结果表明:云南地区过去被鉴定为中华姬鼠的样品均属于澜沧江姬鼠,澜沧江姬鼠与中华姬鼠间的遗传距离(K2P-ds+v)达到0.091,显著超过姬鼠属内种间差距(0.080),支持澜沧江姬鼠独立种的地位;该种不同地理种群可大致以澜沧江为界分为两大支系,且每个支系又各分为两个亚支系;进一步的AMOVA分析表明遗传变异主要来源于两大支系之间,而错配分析与Fu`Fs检验表明澜沧江姬鼠各地理种群及其两个支系都经历过多次扩张事件,这可能是和冰期与间冰期的轮回交替有关;分子系统树和中介网络图表明地理环境的隔离对于澜沧江姬鼠种群分化存在明显影响,其中澜沧江的阻隔作用最为显著。基于松散分子钟(Relax molecular clock)分析,中华姬鼠和澜沧江姬鼠的分歧时间大约在2.98 Ma(95%HPD: 4.32-1.88),而澜沧江姬鼠则在1.13 Ma(95%HPD: 1.95-0.65)分成两个支系。按照平均分歧时间来看,澜沧江姬鼠两个支系的的分歧事件发生在鄱阳冰期(1.2-0.9 Ma),两个支系内部进一步分化为两支的时间非常接近,分别为:Clade 1中为0.67 Ma (95%HPD: 1.17-0.34)和Clade 2 中为0.64 Ma (95%HPD: 1.17-0.36),这种隔离种群各自产生分化的时间却非常接近,这提示其分化事件可能是受到古气候如冰期或间冰期的影响所产生。

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We consider the effect of image forces, arising due to a difference in dielectric permeabilities of the well layer and barrier layers, on the energy spectrum of an electron confined in a rectangular potential well under a magnetic field. Depending on the value and the sign of the dielectric mismatch, image forces can localize electrons near the interfaces of the well or in well centre and change the direct intersubband gaps into indirect ones. These effects can be controlled by variation of the magnetic field, offering possibilities for exact tuning of electronic devices.

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The GaInAsSb/AlGaAsSb/GaSb heterostructures were grown by the liquid phase epitaxy (LPE) technique. The materials were characterized by means of optical microscopy, electroprobe microanalysis (EPMA), double-crystal X-ray diffraction, capacitance-voltage (C-V) and Van der Pauw measurments, infrared absorption spectra, photoluminescence and laser Raman scattering. The results show that the materials have fine surface morphology, low lattice mismatch and good homogeneity. Room-temperature light-emitting diodes with an emission wavelength of 2.2-mu-m were obtained by using the GaInAsSb/AlGaAsSb DH structures.

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We review our investigation of cubic GaN films on (001) GaAs, focusing on the structural, optical, and electrical properties of these films. Cubic GaN films grown epitaxially on GaAs suffer from the large lattice mismatch between these two materials in that they contain extremely high densities of structural defects. Surprisingly, the optical quality of these films does not seem much affected by the presence of defects, as intense photoluminescence is detected a? room temperature and above. Finally, the rather high background electron concentrations in our films is shown to be a consequence of contamination with O and not to be an intrinsic property of cubic phase GaN. (C) 1997 Elsevier Science S.A.

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The theoretical investigation of the coupling efficiency of a laser diode to a single mode fiber via a hemispherical lens on the tip of the tapered fiber in the presence of possible transverse offset and angular mismatch is reported.Without the misalignment,coupling efficiency increases with the decreasing of taper length.With the misalignment,this relation is that the coupling efficiency decreases with each kind of offset.

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Wafer bonding is regardless of lattice mismatch in the integration of dissimilar semiconductor materials. This technology differs from the heteroepitaxy mainly in the mechanism of generating dislocations at the interface. A model of dislocations at the bonded interface is proposed in this paper. Edge-like dislocations, which most efficiently relax the strain, are predominant at the bonded interface. But the thermal stress associated with large thermal expansion misfit may drive dislocations away from the bonded interface upon cooling.