The Acquisition of an Inheritable 50-bp Deletion in the Human mtDNA Control Region Does Not Affect the mtDNA Copy Number in Peripheral Blood Cells

The mitochondrial DNA (mtDNA) control region is believed to play an important biological role in mtDNA replication. Large deletions in this region are rarely found, but when they do occur they might be expected to interfere with the replication of the molecule, thus leading to a reduction of mtDNA copy number. During a survey for mtDNA sequence variations in 5,559 individuals from the general Chinese population and 2,538 individuals with medical disorders, we identified a 50-bp deletion (m.298_347del50) in the mtDNA control region in a member of a healthy Han Chinese family belonging to haplogroup B4c1b2, as suggested by complete mtDNA genome sequencing. This deletion removes the conserved sequence block II (CSBII; region 299-315) and the replication primer location (region 317-321). However, quantification of the mtDNA copy number in this subject showed a value within a range that was observed in 20 healthy subjects without the deletion. The deletion was detected in the hair samples of the maternal relatives of the subject and exhibited variable heteroplasmy. Our current observation, together with a recent report for a benign 154-bp deletion in the mtDNA control region, suggests that the control of mtDNA replication may be more complex than we had thought. Hum Mutat 31:538-543, 2010. (C) 2010 Wiley-Liss, Inc.

Effects of exposure to 50 Hz magnetic field of 1 mT on the performance of detour learning task by chicks

In the present study, we examined the effects of exposure to an extremely low-frequency magnetic field of 1 mT intensity on learning and memory in Lohmann brown domestic chicks using detour learning task. These results show that 20 h/day exposure to a low

Effects of Prenatal Exposure to a 50-Hz Magnetic Field on One-Trial Passive Avoidance Learning in 1-Day-Old Chicks

We investigated memory impairment in newly hatched chicks following in ovo exposure to a 50-Hz magnetic field (MF) of 2 mT (60 min/day) on embryonic days 12-18. Isolated and paired chicks were used to test the effect of stress during training, and memory retention was tested at 10, 30, and 120 min, following exposure to a bitter-tasting bead (100% methylanthranilate). Results showed that memory was intact at 10 min in both isolated and paired chicks with or without MF exposure. However, while isolated chicks had good memory retention levels at 30 and 120 min, those exposed to MF did not. The results suggest a potential disruption of memory formation following in ovo exposure to MF, with this effect only evident in the more stressed, isolated chicks. Bioelectromagnetics 31:150-155, 2010. (C) 2009 Wiley-Liss. Inc.

提高IC测试系统性价比的研究

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

提高IC测试系统性价比的研究-定时系统、图形发生器的设计

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

数模IC测试系统的工程化设计

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

多值数模IC测试系统的研制与开发

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

数模混合IC测试系统的研制

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

提高IC测试系统性价比的研究

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

数模IC测试系统关键部件的研究

Submitted by zhangdi (zhangdi@red.semi.ac.cn) on 2009-04-13T11:45:31Z

计算机测试程序开发及IC测试与应用开发系统

于G批量导入至Hzhangdi

黄土高原地区50年降水时空动态与趋势分析

基于黄土高原及周边地区74个气象站1952-2001年降水量数据,计算各站年降水量线性趋势系数,利用ArcGIS地统计模块普通Kriging插值法生成黄土高原地区1952-2001年年降水量和年降水量线性趋势表面,分析年降水量、年降水量线性趋势表面时空分布特征与10年尺度降水量带动态变化。结果表明,黄土高原地区1952-2001年平均年降水量(426.69±67.85)mm,年降水量和年降水量线性趋势存在显著时空分异;年降水量由西向东线性增加,从南到北二次曲线递减,总体上东南西北方向递减;10年尺度平均年降水量减少趋势明显,递减率-10.019 mm/10 a,期间累计减少1227.33 mm;200,400,600 mm降水线南移,干旱半干旱区面积不显著扩大,湿润半湿润区显著缩小,气候呈干旱化趋势;年降水量线性趋势系数从-4.10 mm/a到4.46 mm/a,平均-0.98 mm/a,降水量呈增加趋势地区面积16.36万km2,呈减少趋势地区面积46.27万km2,分占黄土高原地区总面积26.12%和73.88%。

金属溶剂萃取的热力学研究 1.Er(NO_3)_3-TB -C_6H_(14) 体系2.CuSo_4-氨化P_(50)-16H_(14)体系

本文在溶液理论的基础上，用纯热力学方法研究了中性磷萃取剂-金属体系（TBP-Er(no_3)_3）和氨化P_(50)-金属体系（P_(50)-cus04）的平衡计算模型。对于TBP体系有下列萃取平衡Er(NO_3)_3 (a) + 3TBP_((0)) <-> Er(NO_3)_3. 3TBP_((0))对于氨化P50体系，在萃取剂大量过量下有下的平衡Er(NO_3)_3 (a) + 3TBP_((0)) <-> Er(NO_3)_3. 3TBP(0)对氧化P50体系，在萃取剂大量过量下有下的平衡Cu_((a))~(2+) + partial deriv H_2R_2_((0)) <-> Cu(HR_2)_2 + 2H~+。用Scatchard-hildebrand模型预测了C_6H_(24)-TBP二元体系的担力学性质，以近似地用于H_2O - 16H_4 - TBP三之体系，减少了实验工作量。用气相色谱法求得了三之体系H_2O - (6H_(14) - P_(50))的热力学平衡数据，由于改进了进样系统，使实验误差<2%。对二体系的水相，均采用Pitzer理论求算γ_(Er(WO_3)_3)，和γ_(Cn~(2+))。对有机相，用热力学关系求出了水，正已烷，萃取剂，的活度系数。实验结果用Scatchard-Hildebrand模型进行关联。使计算机上进行回归处理，求得萃取反应的热力学平衡常数Ka和萃合物的活度系数。计算中，将有效平衡常数进一步分解，以提出显函数项，并在图解数分中改进了计算方法，使得每条萃取等温成都解得到合理的积分值。Schatchard-Hildebrand模型能在较宽的有机相浓度区域应用。所得到的端值常数，可定性地分析各组分的相互作用。

近50年海南岛红树林群落的变化及其与环境关系分析——以东寨港、三亚河和青

以三亚湾泰莱藻为例，对海草光谱特征进行分析。结果表明，450-780nm是海草光

近50年全球气候变暖对珠江口海平面变化趋势的影响

根据1957～2006年全球温度和珠江口验潮站平均潮位资料，分析全球气候变暖