Juan Antonio de Zamacola: vida, obra y concepción esteticomusical

Tesis doctoral originalmente defendida en la Universidad de Deusto el 29-09-2000

Un modelo de programación por metas para la elaboración del contrato-programa de un hospital público

[ES] Proponemos un modelo de programación por metas para la estimación del plan de producción (case-mix) que debe reflejarse en el Contrato–Programa que suscriben anualmente los Hospitales Públicos y la Administración. Las variables de decisión son los volúmenes de actividad de cada servicio médico del hospital y los atributos son los indicadores básicos que se manejan al elaborar el Contrato-Programa: fi nanciación, número de altas, estancia media y peso de complejidad. Para resolver nuestro modelo empleamos la herramienta SOLVER de la hoja de cálculo EXCEL. La utilización de esta herramienta permite simular varios escenarios de una manera ágil, lo que es de gran ayuda para el estudio y discusión de las cantidades a contratar entre el Hospital y la Administración. El artículo finaliza con una breve presentación de los resultados obtenidos al aplicar nuestro modelo a un hospital de tamaño medio (118 camas) del Servicio Vasco de Salud.

Finantza-erakundeen kudeaketa

Oro har finantza-erakunde baten kudeaketa ikuspegi praktiko batetik ezagutu nahi duen edozeinentzat erabilgarria da lan hau. Hain zuzen ere, graduko eta postgraduko finantza-arloko irakasleei, sektore honetako profesionalei eta, baita banku-eragiketak hobetu ulertu nahi dituzten inbertsiogile partikularrei ere zuzentzen da.

Collision tumour involving a rectal gastrointestinal stromal tumour with invasion of the prostate and a prostatic adenocarcinoma

Background: Gastrointestinal stromal tumours (GISTs) are the most common primary mesenchymal neoplasia in the gastrointestinal tract, although they represent only a small fraction of total gastrointestinal malignancies in adults (<2%). GISTs can be located at any level of the gastrointestinal tract; the stomach is the most common location (60-70%), in contrast to the rectum, which is most rare (4%). When a GIST invades into the adjacent prostate tissue, it can simulate prostate cancer. In this study, we report on a case comprising the unexpected collision between a rectal GIST tumour and a prostatic adenocarcinoma. Findings: We describe the complexity of the clinical, endoscopic and radiological diagnosis, of the differential diagnosis based on tumour biopsy, and of the role of neoadjuvant therapy using imatinib prior to surgical treatment. Conclusions: Although isolated cases of coexisting GISTs and prostatic adenocarcinomas have reviously been described, this is the first reported case in the medical literature of a collision tumour involving a rectal GIST and prostatic adenocarcinoma components.

Osakidetzako erietxe bateko jardueraren eta aurrekontu zuzkiduraren egokitzapena

Idazleen nahia, esatariaren lehentasunak eta antolaketa mugaketak kontuan izanik, helburu anitzeko eredu bat zehaztea da, horrela Osakidetzako erietxe konkretu bateko jarduera zehaztu ahal izango dugu eta beraz, baita aurrekontuaren esleipena. Aldi berean, aurrekontu zuzkidura doituz, zentroaren baliabideen erabilpenaren efizientzia azter dezakegu eta orokorrean, zentroaren osasun-laguntzen emaitzak hobetzen lagundu dezakete.

Proof of Concept of Impact Detection in Composites Using Fiber Bragg Grating Arrays

Impact detection in aeronautical structures allows predicting their future reliability and performance. An impact can produce microscopic fissures that could evolve into fractures or even the total collapse of the structure, so it is important to know the location and severity of each impact. For this purpose, optical fibers with Bragg gratings are used to analyze each impact and the vibrations generated by them. In this paper it is proven that optical fibers with Bragg gratings can be used to detect impacts, and also that a high-frequency interrogator is necessary to collect valuable information about the impacts. The use of two interrogators constitutes the main novelty of this paper.

Alegia klasikoak euskaraz: Isopeteko, La Fontaineren eta Samaniegoren alegien berridazketen azterketa

521 p.

Cogeneración de procesos en el desarrollo de una práctica escultórica

96 p. : il.

The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed that the polymorphism Leu374Phe (L374F, rs16891982) was statistically associated with skin color variability within this sample. In particular, allele 374F was significantly more frequent among the individuals with lighter skin. Further genotyping an independent set of 558 individuals of a geographically wider population with known ancestry in the Spanish population also revealed that the frequency of L374F was significantly correlated with the incident UV radiation intensity. Selection tests suggest that allele 374F is being positively selected in South Europeans, thus indicating that depigmentation is an adaptive process. Interestingly, by genotyping 119 melanoma samples, we show that this variant is also associated with an increased susceptibility to melanoma in our populations. The ultimate driving force for this adaptation is unknown, but it is compatible with the vitamin D hypothesis. This shows that molecular evolution analysis can be used as a useful technology to predict phenotypic and biomedical consequences in humans.

Ibilgailu industrial baten transmisioaren diseinuaren proiektua

Ibilgailu industrial (kamioi) baten transmisio sistemaren diseinua burutu da. Motorraren potentzia 238 CV da eta transmisioa mekanikoa da, atzeko trakzioa du eta aurrekoa akoplagarria da.

El plasma rico en factores de crecimiento como alternativa terapéutica en el ojo seco y en defectos epiteliales persistentes

184 p.

La ética y el riesgo moral de las entidades financieras

[ES] Actualmente nos econtramos sumergidos en una de las mayores crisis económicas conocidas hasta el momento, la cual ha dado lugar a diversos debates sobre las posibles causas de la misma. Entre ellas, últimamente, han tomado cierta relevancia términos como la ética bancaria y el riesgo moral, los cuales permiten establecer una concordancia entre las actitudes de la banca en los años previos al año 2007 y el estallido de la crisis económica. Es necesario, por tanto, el análisis de casos concretos como Bankia, CAM y BBVA para conocer con exactitud las buenas y malas gestiones desarrolladas por las entidades financieras de nuestro entorno en los citados años. Asimismo, conviene mostrar las consecuencias de aquellas actitudes, como la pérdida de la confianza por parte de la clientela, para determinar las medidas adoptadas con objeto de reconducir el sistema financiero español, lo cual permite evaluar su grado de efectividad.

Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Paleoambiente y antropización en los Pirineos de Navarra durante el Holoceno medio (VI-IV PDF milenios cal. BC): Una perspectiva palinológica

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas

An approach version of fuzzy metric spaces including an ad hoc fixed point theorem

In this paper, inspired by two very different, successful metric theories such us the real view-point of Lowen's approach spaces and the probabilistic field of Kramosil and Michalek's fuzzymetric spaces, we present a family of spaces, called fuzzy approach spaces, that are appropriate to handle, at the same time, both measure conceptions. To do that, we study the underlying metric interrelationships between the above mentioned theories, obtaining six postulates that allow us to consider such kind of spaces in a unique category. As a result, the natural way in which metric spaces can be embedded in both classes leads to a commutative categorical scheme. Each postulate is interpreted in the context of the study of the evolution of fuzzy systems. First properties of fuzzy approach spaces are introduced, including a topology. Finally, we describe a fixed point theorem in the setting of fuzzy approach spaces that can be particularized to the previous existing measure spaces.