Importancia de la cartera de referencia en la evaluación de los fondos de inversión españoles a través del alfa de Jensen

Este trabajo ha sido presentado como ponencia en el XI Congreso Internacional de la Asociación de Dirección y Economía de la Empresa (AEDEM), celebrada en París en septiembre de 2002.

Marketin Plana: Alfa Deco Subconjuntos, S.A.

Lan honek Alfa Deco Subconjuntos, S.A. enpresaren marketin plan bat biltzen du. Bertan marketin plan baten pausuak eta atalak kasu erreal batera eram dira. Lana euskera dago.

Actividad de receptores muscarínicos y cannabinoides tras un tratamiento subcrónico con el agonista cannabinoide WIN55,212-2

La enfermedad de Alzheimer es el desorden neurológico relacionado con la edad más común en la actualidad que se caracteriza por la neuroinflamación y por la pérdida de neuronas colinérgicas asociada a una disfunción progresiva de la memoria y de la cognición. Este trabajo estudia la relación entre el sistema cannabinoide y la enfermedad de Alzheimer, para demostrar que lo cannabinoides sintéticos se muestran como potenciales herramientas farmacológicas para el tratamiento de enfermedades neurodegenerativas, sobre todo asociadas a déficits cognitivos, como podría ser la enfermedad de Alzheimer.

Catalytic asymmetric synthesis of alfa,alfa-disubstituted alfa-thio- and alfa-amino acid derivatives

449 p.

Alfa'-oxy enones and pyrrolidin-2,3-diones as efficient new templates in asymmetric organocatalytic Michael reactions

470 p.

Regulación de la transcripción de los genes SND1 (Homo sapiens) y SNDp102 (Rattus norvegicus)

167 p. : il., graf.

Métodos numéricos para ecuaciones diferenciales rígidas. Aplicación a la semidiscretización del método de elementos finitos

295 p.

Changes in white adipose tissue metabolism induced by resveratrol in rats

Background: A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the potential underlying mechanisms of action which take place in adipose tissue. Methods: Sixteen male Sprague-Dawley rats were randomly divided into two groups: control and treated with 30 mg resveratrol/kg body weight/d. All rats were fed an obesogenic diet and after six weeks of treatment white adipose tissues were dissected. Lipoprotein lipase activity was assessed by fluorimetry, acetyl-CoA carboxylase by radiometry, and malic enzyme, glucose-6P-dehydrogenase and fatty acid synthase by spectrophotometry. Gene expression levels of acetyl-CoA carboxylase, fatty acid synthase, lipoprotein lipase, hormone-sensitive lipase, adipose triglyceride lipase, PPAR-gamma, SREBP-1c and perilipin were assessed by Real time RT-PCR. The amount of resveratrol metabolites in adipose tissue was measured by chromatography. Results: There was no difference in the final body weight of the rats; however, adipose tissues were significantly decreased in the resveratrol-treated group. Resveratrol reduced the activity of lipogenic enzymes, as well as that of heparin-releasable lipoprotein lipase. Moreover, a significant reduction was induced by this polyphenol in hormone-sensitive lipase mRNA levels. No significant changes were observed in other genes. Total amount of resveratrol metabolites in adipose tissue was 2.66 +/- 0.55 nmol/g tissue. Conclusions: It can be proposed that the body fat-lowering effect of resveratrol is mediated, at least in part, by a reduction in fatty acid uptake from circulating triacylglycerols and also in de novo lipogenesis.

Diferencias individuales en ratones derrotados crónicamente : cambios conductuales, neuroendocrinos, inmunitarios y neurotróficos como marcadores de vulnerabilidad a los efectos del estrés

235 p.

Beta-Hydroxyimino Phosphorus Derivatives. An Efficient Tool in Organic Synthesis

[EN] The purpose of this review article is to illustrate synthetic aspects of functionalized phosphorus derivatives containing an oximo moiety at the beta-position. First section will be focused on the synthesis of phosphine oxides, phosphonates or phosphonium salts containing an oxime group. The synthesis of these derivatives comprises the carbon–phosphorus single bond construction by reaction of haloximes with phosphorus derivatives, nucleophilic addition of phosphorus reagents to carbonyl compounds, or nucleophilic addition of phosphorus reagents to nitro olefins. This section will also concentrate on the most practical routes for the synthesis of the target compounds, through carbon–nitrogen double bond formation, which are as follows: condensation processes of carbonyl compounds and hydroxylamine derivatives or addition of hydroxylamines to allenes or alkynes. The preparative use of beta-oximo phosphorus derivatives as synthetic intermediates will be discussed in a second section, comprising olefination reaction, oxidation of oximes to nitrile oxides by reaction at the C-N double bond of the oxime moiety, oxidation of these substrates to nitrosoalkenes, reduction to the corresponding hydroxylamines and some reactions at the hydroxyl group of the hydroxyimino moiety.

Manejo de la técnica Western Blot. Determinaciones relacionadas con obesidad y diabetes.

23 p.

Resveratrol: Anti-Obesity Mechanisms of Action

Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. The present review aims to compile the evidence concerning the potential mechanisms of action which underlie the anti-obesity effects of resveratrol, obtained either in cultured cells lines and animal models. Published studies demonstrate that resveratrol has an anti-adipogenic effect. A good consensus concerning the involvement of a down-regulation of C/EBPa and PPAR. in this effect has been reached. Also, in vitro studies have demonstrated that resveratrol can increase apoptosis in mature adipocytes. Furthermore, different metabolic pathways involved in triacylglycerol metabolism in white adipose tissue have been shown to be targets for resveratrol. Both the inhibition of de novo lipogenesis and adipose tissue fatty acid uptake mediated by lipoprotein lipase play a role in explaining the reduction in body fat which resveratrol induces. As far as lipolysis is concerned, although this compound per se seems to be unable to induce lipolysis, it increases lipid mobilization stimulated by beta-adrenergic agents. The increase in brown adipose tissue thermogenesis, and consequently the associated energy dissipation, can contribute to explaining the body-fat lowering effect of resveratrol. In addition to its effects on adipose tissue, resveratrol can also acts on other organs and tissues. Thus, it increases mitochondriogenesis and consequently fatty acid oxidation in skeletal muscle and liver. This effect can also contribute to the body-fat lowering effect of this molecule.

Exploring new labelling strategies for boronated compounds: towards fast development and efficient assessment of BNCT drug candidates

208 p.

Eficiencia y persistencia de los fondos de inversión inmobiliaria en España

[ES] El presente trabajo tiene como objeto el estudio de la eficiencia y persistencia de los rendimientos del total de fondos de inversión inmobiliaria españoles, desde el inicio de su actividad a finales de 1994 a agosto de 2012. Para este propósito se ha utilizado el alfa de Jensen, la ratio de Sharpe, y la aproximación propuesta por Carhart (1997). En cuanto a la eficiencia, la ratio de Sharpe presenta valores negativos en los tres primeros años de actividad de cada fondo y valores muy bajos o incluso negativos en los tres o cuatro últimos años. El indicador de Jensen muestra que la mayoría de los fondos presentan un rendimiento inferior al del mercado, aproximado mediante la rentabilidad de la vivienda y una media de la rentabilidad de todos los fondos inmobiliarios. Carteras de referencia vinculadas a los mercados de deuda o bolsa, no resultan significativas. En el análisis de la persistencia de los rendimientos se confirma su existencia a plazo de uno, dos, tres y cuatro años, para todos los fondos. La evidencia obtenida en nuestro trabajo para los fondos inmobiliarios en España, eficiencia inferior a la del mercado y persistencia en los rendimientos, nos permite confirmar la difícil situación que ha atravesado y en la que sigue inmersa este tipo de inversión colectiva, poniendo de manifiesto la necesidad y la urgencia de medidas impulsoras de su actividad.