Resveratrol: Anti-Obesity Mechanisms of Action
Data(s) |
16/10/2015
16/10/2015
01/11/2014
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Resumo |
Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. The present review aims to compile the evidence concerning the potential mechanisms of action which underlie the anti-obesity effects of resveratrol, obtained either in cultured cells lines and animal models. Published studies demonstrate that resveratrol has an anti-adipogenic effect. A good consensus concerning the involvement of a down-regulation of C/EBPa and PPAR. in this effect has been reached. Also, in vitro studies have demonstrated that resveratrol can increase apoptosis in mature adipocytes. Furthermore, different metabolic pathways involved in triacylglycerol metabolism in white adipose tissue have been shown to be targets for resveratrol. Both the inhibition of de novo lipogenesis and adipose tissue fatty acid uptake mediated by lipoprotein lipase play a role in explaining the reduction in body fat which resveratrol induces. As far as lipolysis is concerned, although this compound per se seems to be unable to induce lipolysis, it increases lipid mobilization stimulated by beta-adrenergic agents. The increase in brown adipose tissue thermogenesis, and consequently the associated energy dissipation, can contribute to explaining the body-fat lowering effect of resveratrol. In addition to its effects on adipose tissue, resveratrol can also acts on other organs and tissues. Thus, it increases mitochondriogenesis and consequently fatty acid oxidation in skeletal muscle and liver. This effect can also contribute to the body-fat lowering effect of this molecule. |
Identificador |
Molecules 19 (11) 2014 : 18632-18655 (2014) // Article ID 191118632 1420-3049 http://hdl.handle.net/10810/15915 10.3390/molecules191118632 |
Idioma(s) |
eng |
Publicador |
MDPI |
Relação |
http://www.mdpi.com/1420-3049/19/11/18632 |
Direitos |
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). info:eu-repo/semantics/openAccess |
Palavras-Chave | #resveratrol #adipogenesis #apoptosis #lipogenesis #lipolysis #thermogenesis #fatty acid oxidation #adipose triglyceride lipase #action #3T3-L1 adipocytes #transcriptional control #dietary polyphenols #energy-metabolism #fat movilization #tissue #expression #obesity |
Tipo |
info:eu-repo/semantics/article |