Aproximación al pintor Epifanio Díaz de Arcaute (1845-1910)

[ES]Con este trabajo pretendemos aproximarnos a la figura de Epifanio Díaz de Arcaute (1845-1910), un pintor no demasiado conocido y con una producción artística, por el momento, escasa. Su formación fue tradicional y académica, vinculada a la Academia de Bellas Artes de Vitoria, de la que terminó siendo profesor.

Cartas enviadas por Leonel Acevedo Díaz a Justo Garate entre 1955 y 1961

5 cartas (mecanografiadas y manuscritas) ; entre 170x220mm y 145x230mm. Ubicación: Caja 1 - Carpeta 3

Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity

Background: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety problems led to slow pharmacological development. Therefore, apoptosis inhibition is still considered an unmet medical need. Methodology and Principal Findings: The interaction between Apaf-1 and the inhibitors was confirmed by NMR. Target specificity was evaluated in cellular models by siRNa based approaches. Cell recovery was confirmed by MTT, clonogenicity and flow cytometry assays. The efficiency of the compounds as antiapoptotic agents was tested in cellular and in vivo models of protection upon cisplatin induced ototoxicity in a zebrafish model and from hypoxia and reperfusion kidney damage in a rat model of hot ischemia. Conclusions: Apaf-1 inhibitors decreased Cytc release and apoptosome-mediated activation of procaspase-9 preventing cell and tissue damage in ex vivo experiments and in vivo animal models of apoptotic damage. Our results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

Nuevos datos sobre la estela romana de Puebla de Azaba (Ciudad Rodrigo, Salamanca)

[ES] Damos a conocer la forma y el texto completos de la inscripción de referencia con descubrimiento de tres nuevas líneas de texto y elementos decorativos astrales en cabecera semicircular. En estas líneas se encuentran dos "cognomina" indígenas de la zona de los verrones, uno muy abundante ("Arco") y el otro menos frecuente ("Taginus").

Arquitectura religiosa del Renacimiento en Álava (1530-1611)

601 p.

Policy Coordination in an Oligopolistic Housing Market

This paper analyzes the consequences of the interaction between two different levels of government (regulators) in the development of housing policy when their decisions determine the level of competition in the housing market. The analysis discusses the implications derived from a lack of coordination between a local regulator who controls the supply of land for housing development and a central regulator who decides on housing subsidies. The results suggest that lack of coordination has significant effects on prices and supply of houses, housing developers’ profits, and buyers’ surplus.

Ad valorem housing subsidies may reduce house building

In this paper it is shown that an ad valorem housing subsidy set by a central regulator (or a raise in the ad valorem housing subsidy rate) may reduce the number of houses built in the market and increase the price paid by the buyers of houses. The analysis considers a situation where there is imperfect competition in the housing market and a local regulator that decides on density, or on the number of sites for housing development, and that cares about a combination of the profits of housing developers and the surplus of buyers of houses.

Social Housing under Oligopoly

In this paper it is shown that the setting up of a social housing system may decrease the total number of houses built in the market, induce a price of non-social houses greater than the price of houses without that system and increase the profits of housing developers even in situations where they have to sell social houses at a price below production cost. The analysis considers a situation with imperfect competition in the housing market and with a social housing system where housing developers must provide some social houses when they obtain a permit to build non-social houses.

Non-Stationary Demand in a Durable Goods Monopoly

In a context where demand for the services of a durable good changes over time, and this change may be uncertain, the paper shows that social welfare may be higher when the monopolist seller can commit to any future price level she wishes than when she cannot. Moreover, the equilibrium under a monopolist with commitment power may Pareto-dominate the equilibrium under a monopolist without commitment ability. These results affect the desired regulation of a durable goods monopolist in this context.

Vertical Differentiation and Entry Deterrence: A Reconsideration

In this work we emphasize why market coverage should be considered endogenous for a correct analysis of entry deterrence in vertical differentiation models and discuss the implications of this endogeneity for that analysis. We consider contexts without quality costs and also contexts with convex fixed quality costs.

EUSMT: incorporating linguistic information to SMT for a morphologically rich language. Its use in SMT-RBMT-EBMT hybridation

148 p.: graf.

The Metabolic Core and Catalytic Switches Are Fundamental Elements in the Self-Regulation of the Systemic Metabolic Structure of Cells

19 p.

Análisis estratégico de la industria de la construcción en España

[ES] El sector de la construcción tiene, en España, una notable importancia, por su aportación al PIB (del entorno del 10%) y al empleo (en torno al 10%) y porque aglutina un amplio tejido empresarial. El deterioro de la situación económica y la saturación del mercado residencial han llevado a una fuerte contracción de la actividad constructiva, después una larga época de crecimiento.

Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering

8 p.

La pena de muerte en la Corona de Castilla en la Edad Media

[ES]A lo largo de este artículo se pasan revista a cinco cuentiones que muestran la evolución de la pena de muerte en la Corona de Castilla a lo largo de la Edad Media. En primer lugar, se presta atención al paso de la ejecución privada de la justicia a la pública y en qué casos se mantuvo la venganza, aunque con la autorización judicial. En segundo lugar, se pasa revista a las formas de aplicar la pena de muerte, privilegiando los siguientes tipos: el ahorcamiento por los pies, el asaeteamiento, el empozamiento y el encubamiento. En tercer lugar, se expone el ritual de ejecución de las penas capitales desde que el reo sale de la cárcel y es conducido al cadalso, hasta que el cuerpo es sepultado o queda expuesto a perpetuidad. En cuarto lugar, se reflexiona sobre la incidencia de la rebeldía o contumacia del acusado ante los requerimientos de la justicia en la imposición de la pena de muerte. En quinto y último lugar, se analizan las circunstancias que llevaron a la Corona de Castilla, a partir del último tercio del siglo XV, a relegar la pena de muerte entre el elenco punitivo y preferir castigos que tuvieran utilidad pública.