Fine mapping and functional analysis of the multiple sclerosis risk gene CD6

CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation. In this study, we performed a haptag SNP screen of the CD6 gene locus using a total of thirteen tagging SNPs, of which three were non-synonymous SNPs, and replicated the recently reported GWAS SNP rs650258 in a Spanish-Basque collection of 814 controls and 823 cases. Validation of the six most strongly associated SNPs was performed in an independent collection of 2265 MS patients and 2600 healthy controls. We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2nd SRCR domain with susceptibility to MS (Pmax(T) permutation=161024). The effect of these haplotypes on CD6 surface expression and cytokine secretion was also tested. The analysis showed significantly different CD6 expression patterns in the distinct cell subsets, i.e. – CD4+ naı¨ve cells, P = 0.0001; CD8+ naı¨ve cells, P,0.0001; CD4+ and CD8+ central memory cells, P = 0.01 and 0.05, respectively; and natural killer T (NKT) cells, P = 0.02; with the protective haplotype (RA) showing higher expression of CD6. However, no significant changes were observed in natural killer (NK) cells, effector memory and terminally differentiated effector memory T cells. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4+ and CD8+ T cells.

Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players

11 p.

La consommation du vin en Grèce ancienne: idéalisation et réalité

Forma parte del dossier "Penser les banquets grec et romain, Entre représentations et pratiques". Actes de la table ronde Le banquet dans l'Antiquité 6 janvier 2007, Institut national d'histoire de l'art - Paris. Coordinado por Robin Nadeau

Voisinage et hábitat dans les communautés des Pyrénées Occidentales entre le XV et le XVIIIe siècles : de la croissance au blocage

Publicado dentro de la colección «Méridiennes» (ISSN: 1950-0130)

Les jeunes face au marché du travail en France: entre difficultés d´insertion et stratégies de pénétration

En une génération, entre 1975 et 1995, le paysage du marché du travail auquel les jeunes font face a radicalement changé.

Nourriture et santé dans la médecine grecque ancienne

Presentado en el IIe Colloque International de l'IEHA: « Un aliment sain dans un corps sain ». Perspectives historiques - «Healthy Food in a Healthy Body», organizado por el Institut Européen d'Histoire de l'Alimentation y celebrado en Tours los días 14 y 15 de diciembre de 2002.

L'économie argelienne et ses connexions avec l' Union Européenne de l'indépendance à l'actualité

Analyse about all the economical connexions between the European Union and Algeria since 1962 until 2014.

Donati Artis Grammaticae Index et Concordantia

615 p.

HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection.