HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
Data(s) |
10/12/2015
10/12/2015
01/07/2014
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Resumo |
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. |
Identificador |
PLOS Pathogens 10(7) 2014 : (2014) // Article ID e1004146 1553-7366 1553-7374 http://hdl.handle.net/10810/16420 10.1371/journal.ppat.1004146 |
Idioma(s) |
eng |
Publicador |
Public Library Science |
Relação |
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004146#abstract0 |
Direitos |
© 2014 Izquierdo-Useros et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. info:eu-repo/semantics/openAccess |
Palavras-Chave | #human-immunodefiency virus #C-type lectin #subcapsular sinus macrophages #CD4(+) T-cells #DC-sign #plasma-membrane #influenza-virus #trans-infection #sialic-acid #immunological synapse |
Tipo |
info:eu-repo/semantics/article |