Interpretación de información geométrica procedente de diversas fuentes para la reconstrucción virtual del Palacio de los Condestables, Casalarreina (La Rioja)

[ES] Este proyecto se ha realizado a partir de los datos del siguiente proyecto de documentación geométrica, desde donde pueden encontrarse enlaces adicionales a otros documentos relacionados:

Virtual Reconstruction of the Ancient State of a Ruined Church

Contributed to: 4th International Conference, EuroMed 2012, Limassol, Cyprus, October 29 – November 3, 2012.

Metabolic efficiency with fast spiking in the squid axon

Fundamentally, action potentials in the squid axon are consequence of the entrance of sodium ions during the depolarization of the rising phase of the spike mediated by the outflow of potassium ions during the hyperpolarization of the falling phase. Perfect metabolic efficiency with a minimum charge needed for the change in voltage during the action potential would confine sodium entry to the rising phase and potassium efflux to the falling phase. However, because sodium channels remain open to a significant extent during the falling phase, a certain overlap of inward and outward currents is observed. In this work we investigate the impact of ion overlap on the number of the adenosine triphosphate (ATP) molecules and energy cost required per action potential as a function of the temperature in a Hodgkin–Huxley model. Based on a recent approach to computing the energy cost of neuronal action potential generation not based on ion counting, we show that increased firing frequencies induced by higher temperatures imply more efficient use of sodium entry, and then a decrease in the metabolic energy cost required to restore the concentration gradients after an action potential. Also, we determine values of sodium conductance at which the hydrolysis efficiency presents a clear minimum.

Neurotransmitter signaling in the pathophysiology of microglia

Erratun publicado en Frontiers in Cellular Neuroscience 7 : (2013) // Article ID 107

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections and disease. In addition, microglia has a more benign, less explored role as the brain professional phagocytes. Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. In addition, microglia phagocytoses brain-specific cargo, such as axonal and myelin debris in spinal cord injury or multiple sclerosis, amyloid-beta deposits in Alzheimer's disease, and supernumerary synapses in postnatal development. Common mechanisms of recognition, engulfment, and degradation of the different types of cargo are assumed, but very little is known about the shared and specific molecules involved in the phagocytosis of each target by microglia. More importantly, the functional consequences of microglial phagocytosis remain largely unexplored. Overall, phagocytosis is considered a beneficial phenomenon, since it eliminates dead cells and induces an anti-inflammatory response. However, phagocytosis can also activate the respiratory burst, which produces toxic reactive oxygen species (ROS). Phagocytosis has been traditionally studied in pathological conditions, leading to the assumption that microglia have to be activated inorder to become efficient phagocytes. Recent data, however, has shown that unchallenged microglia phagocytose apoptotic cells during development and in adult neurogenic niches, suggesting an overlooked role in brain remodeling throughout the normal lifespan. The present review will summarize the current state of the literature regarding the role of microglial phagocytosis in maintaining tissue homeostasis in health as in disease.

Uso de la Realidad Aumentada para facilitar la lectura e interpretación de planos

[ES] Este proyecto genera productos adicionales de trabajos también disponibles en el repositori, en concreto:

Problems when generating virtual models representing real objects: Hondarribia walls

[EN] This paper is based in the following project:

Enfoque cartogr??fico de los modelos virtuales de elementos patrimoniales

[ES] Los modelos virtuales de edificios hist??ricos u otros elementos patrimoniales cuentan con una gran variedad de aplicaciones relacionadas, sobre todo, con la difusi??n y multimedia. Aunque en muchas ocasiones se trata de productos eminentemente inform??ticos en los que la componente geom??trica y, por lo tanto topogr??fica, es muy limitada, existen aplicaciones, como los estudios hist??ricos, en los cuales, es necesario que estos modelos representen fielmente la geometr??a y las texturas. En estos casos, los modelos pueden considerarse como productos cartogr??ficos. A continuaci??n se hace una recapitulaci??n de las conclusiones a las que hemos llegado durante los ??ltimos dos a??os despu??s de haber desarrollado una veintena de proyectos en este campo.

Propuesta de catálogo para la selección de rodamientos de vuelco en aplicaciones cuasiestáticas

[ES]La propuesta de catálogo realizada en este proyecto, cuyo objetivo es convertirse en el catálogo de la empresa de rodamientos Iraundi S.A., constará de dos partes. La primera de ellas será una parte teórica e informativa que incluirá toda la información necesaria sobre la manipulación, montaje, mantenimiento y selección del tipo de rodamiento. Para ello se ha recabado información tanto del propio catálogo de Iraundi S.A., como de varios de los fabricantes de rodamientos más importantes del momento, como son INA, GOIMO, ROTHE-ERDE, y SKF. La segunda parte del catálogo lo formaran las tablas y gráficas de selección de rodamiento. Estas gráficas han sido renovadas con respecto al catálogo existente, y se ha tratado de conseguir unas gráficas que sean fáciles de interpretar, y que de manera sencilla se puedan obtener los tamaños y tipos de rodamiento adecuados, dependiendo de la aplicación de funcionamiento y de las fuerzas radiales, axiales y de momento que estos vayan a soportar. Éstas gráficas han sido calculadas exclusivamente para este proyecto, y validadas mediante la aplicación de elementos finitos, de los que finalmente se han obtenido unas gráficas que simplifican la selección óptima del rodamiento, y que tienen en cuenta el esfuerzo axial, radial, y momento que soportará el rodamiento, así como las fuerzas que serán capaces de soportar los tornillos empleados para el anclaje.

Uptake and factors that influence the use of 'sit less, move more' occupational intervention strategies in Spanish office employees

Background: Little is known about the types of 'sit less, move more' strategies that appeal to office employees, or what factors influence their use. This study assessed the uptake of strategies in Spanish university office employees engaged in an intervention, and those factors that enabled or limited strategy uptake. Methods: The study used a mixed method design. Semi-structured interviews were conducted with academics and administrators (n = 12; 44 +/- 12 mean SD age; 6 women) at three points across the five-month intervention, and data used to identify factors that influenced the uptake of strategies. Employees who finished the intervention then completed a survey rating (n = 88; 42 +/- 8 mean SD age; 51 women) the extent to which strategies were used [never (1) to usually (4)]; additional survey items (generated from interviewee data) rated the impact of factors that enabled or limited strategy uptake [no influence (1) to very strong influence (4)]. Survey score distributions and averages were calculated and findings triangulated with interview data. Results: Relative to baseline, 67% of the sample increased step counts post intervention (n = 59); 60% decreased occupational sitting (n = 53). 'Active work tasks' and 'increases in walking intensity' were the strategies most frequently used by employees (89% and 94% sometimes or usually utilised these strategies); 'walk-talk meetings' and ` lunchtime walking groups' were the least used (80% and 96% hardly ever or never utilised these strategies). 'Sitting time and step count logging' was the most important enabler of behaviour change (mean survey score of 3.1 +/- 0.8); interviewees highlighted the motivational value of being able to view logged data through visual graphics in a dedicated website, and gain feedback on progress against set goals. 'Screen based work' (mean survey score of 3.2 +/- 0.8) was the most significant barrier limiting the uptake of strategies. Inherent time pressures and cultural norms that dictated sedentary work practices limited the adoption of 'walk-talk meetings' and ` lunch time walking groups'. Conclusions: The findings provide practical insights into which strategies and influences practitioners need to target to maximise the impact of 'sit less, move more' occupational intervention strategies.

Enpresen sorkuntzak eta desegiteak

Lan honen helburua, Espainiako enpresen sorkuntzetan eta desegitetan 2005-2014 bitartean izandako bilakaera aztertzea da. Horretarako Espainiako datuak beste herrialde batzueko datuekin konparatuz erantzuna emango da. Espainiako kasuan sakontzeko sektoreen eta komunitateen azterketa ere egingo da. Konparatzeko, datu kuantitatiboak zein grafikoak analisi kualitatiboekin batera erabiliko dira. Beraz analisi deskriptiboa nagusi izango da.