La Internalización de los Costes Medioambientales en el transporte de mercancías por carretera

[ES] La literatura existente señala el potencial de una gestión medioambiental proactiva en la generación de capacidades organizativas relativas a la minimización de costes. Además, durante los últimos años, la internalización de los costes medioambientales de la industria transportista ha sido un importante objetivo en el desarrollo de políticas públicas.

Adición conjugada asimétrica de equivalentes umpolung de acilo y carboxilo : auxiliares quirales vs organocatálisis

365 p.

Dámaso Alonso's translations of the passive voice in El retrato del artista adolescente: Further considerations

Eguíluz, Federico; Merino, Raquel; Olsen, Vickie; Pajares, Eterio; Santamaría, José Miguel (eds.)

El franciscano Alonso de Mella tras el espejo: Los "Herejes de Durango" en la historiografía y la literatura

Antonio Duplá Ansuátegui, Piedad Frías Nogales e Iban Zaldúa (editores)

Cartas enviadas por Armando Alonso a Justo Garate entre 1938 y 1939

2 caras (manuscritas) ; 215x145mm. Ubicación: Caja 1 - Carpeta 22

Huerto urbano comunitario

El proyecto que se expone a continuación consiste en la creación de un Huerto Urbano Comunitario. Los criterios en los que se sustenta son; la soberanía alimentaria, el desarrollo comunitario y la sostenibilidad. Se pretende con él que los participantes adquieran formación y conciencia crítica sobre los modos de producción y consumo agrícola. Para ello se estimulará la implicación mediante dinámicas de grupo, charlas, proyecciones, excursiones, debates, etc. Sin olvidarnos en ningún momento del trabajo manual y todas las acciones necesarias para la creación del propio huerto.

Efecto antitumoral de la terfenadina, antagonista del receptor H1 de la histamina, mediado por el complejo I mitocondrial

180 p.

The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed that the polymorphism Leu374Phe (L374F, rs16891982) was statistically associated with skin color variability within this sample. In particular, allele 374F was significantly more frequent among the individuals with lighter skin. Further genotyping an independent set of 558 individuals of a geographically wider population with known ancestry in the Spanish population also revealed that the frequency of L374F was significantly correlated with the incident UV radiation intensity. Selection tests suggest that allele 374F is being positively selected in South Europeans, thus indicating that depigmentation is an adaptive process. Interestingly, by genotyping 119 melanoma samples, we show that this variant is also associated with an increased susceptibility to melanoma in our populations. The ultimate driving force for this adaptation is unknown, but it is compatible with the vitamin D hypothesis. This shows that molecular evolution analysis can be used as a useful technology to predict phenotypic and biomedical consequences in humans.

Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation

We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after ultraviolet-B (UVB) radiation at different time points to investigate the mechanisms by which melanocytes protect human skin from the damaging effects of UVB. Further, we assessed the effect of different keratinocyte-conditioned media (KCM+ and KCM-) on melanocytes. Our results suggest that an interaction between ribosomal proteins and the P53 signaling pathway may occur in response to UVB in both DM and LM. We also observed that DM and LM show differentially expressed genes after irradiation, in particular at the first 6h after UVB. These are mainly associated with inflammatory reactions, cell survival or melanoma. Furthermore, the culture with KCM+ compared with KCM- had a noticeable effect on LM. This effect includes the activation of various signaling pathways such as the mTOR pathway, involved in the regulation of cell metabolism, growth, proliferation and survival. Finally, the comparison of the transcriptional profiles between LM and DM under basal conditions, and the application of natural selection tests in human populations allowed us to support the significant evolutionary role of MIF and ATP6V0B in the pigmentary phenotype.

Fisioterapeuta de empresa: bienestar y progreso en el ámbito laboral

OBJETIVOS: 3.1. Analizar los aspectos legales del fisioterapeuta de empresa en España.- 3.2. Analizar la figura del fisioterapeuta de empresa en España, Europa, y en otros países.- 3.3. Establecer las funciones del fisioterapeuta de empresa en el ámbito de la prevención de riesgos laborales.- 3.4. Analizar los posibles beneficios socio-económicos que conlleva la implementación de la fisioterapia de empresa.- 3.5. Estudiar el ámbito laboral actual y el futuro del fisioterapeuta de empresa.-- HELBURUAK: 3.1. Espainian enpresa-fisioterapeutaren aspektu legalak aztertzea.- 3.2. Enpresa-fisioterapeutaren irudia aztertzea Espainia, Europa eta beste herrialde batzuetan.- 3.3. Enpresa-fisioterapeutaren funtzioak ezartzea lan arriskuen prebentzio eremuan.- 3.4. Enpresa-fisioterapeutaren inplementazioak ekar ditzaken onura sozio-ekonomiko posibleak aztertzea.- 3.5. Gaur egungo lan eremua eta enpresa-fisioterapeutaren etorkizuna aztertzea.