Influence of synthetic method on the properties of La0.5Ba0.5FeO3 SOFC cathode

Power Point presentado en The Energy and Materials Research Conference - EMR2015 celebrado en Madrid (España) entre el 25-27 de febrero de 2015

Competitividad en la empresa de distribución comercial. Caso Eroski

[ES]El presente Trabajo de Fin de Grado tiene como objetivo analizar la competitividad dentro del sector de la distribución comercial con el fin de que los lectores de este trabajo reciban una serie de pautas a la hora de aumentar la competitividad en este sector. Para su realización, en primer lugar, se hará una breve introducción sobre las principales teorías acerca de la competitividad, los factores que afectan a esta y el contexto económico-social que impera en el entorno. En segundo lugar, se procederá a un análisis del estado del arte del sector de la distribución comercial acompañado de un análisis mediante El modelo de las cinco fuerzas de Porter. En tercer lugar, se realizara un análisis de un caso real como es el caso de la planta de Eroski en Elorrio con el fin de ilustrar de una forma más clara todo lo mencionado anteriormente. Se visualizara como a través de la inversión en ser más competitivos Eroski ha mejorado su proceso de logística interna. Por último, se presenta un desglose de los gastos que conlleva realizar la elaboración de un estudio de estas características, así como un desglose de las diferentes tareas a llevar a cabo y la duración de cada una de ellas.

Predictive score for mortality in patients with COPD exacerbations attending hospital emergency departments

Background: Limited information is available about predictors of short-term outcomes in patients with exacerbation of chronic obstructive pulmonary disease (eCOPD) attending an emergency department (ED). Such information could help stratify these patients and guide medical decision-making. The aim of this study was to develop a clinical prediction rule for short-term mortality during hospital admission or within a week after the index ED visit. Methods: This was a prospective cohort study of patients with eCOPD attending the EDs of 16 participating hospitals. Recruitment started in June 2008 and ended in September 2010. Information on possible predictor variables was recorded during the time the patient was evaluated in the ED, at the time a decision was made to admit the patient to the hospital or discharge home, and during follow-up. Main short-term outcomes were death during hospital admission or within 1 week of discharge to home from the ED, as well as at death within 1 month of the index ED visit. Multivariate logistic regression models were developed in a derivation sample and validated in a validation sample. The score was compared with other published prediction rules for patients with stable COPD. Results: In total, 2,487 patients were included in the study. Predictors of death during hospital admission, or within 1 week of discharge to home from the ED were patient age, baseline dyspnea, previous need for long-term home oxygen therapy or non-invasive mechanical ventilation, altered mental status, and use of inspiratory accessory muscles or paradoxical breathing upon ED arrival (area under the curve (AUC) = 0.85). Addition of arterial blood gas parameters (oxygen and carbon dioxide partial pressures (PO2 and PCO2)) and pH) did not improve the model. The same variables were predictors of death at 1 month (AUC = 0.85). Compared with other commonly used tools for predicting the severity of COPD in stable patients, our rule was significantly better. Conclusions: Five clinical predictors easily available in the ED, and also in the primary care setting, can be used to create a simple and easily obtained score that allows clinicians to stratify patients with eCOPD upon ED arrival and guide the medical decision-making process.

Sistemas económicos: variedades de capitalismo.Planificación en las Economías de la OCDE entre 1945 y 1973/Las Economías de Mercado con Planificación indicativa.

[ES] Este trabajo expone en qué consistió y qué importancia económica y organizativo-administrativa tuvo la denominada planificación indicativa, en los países de la OCDE, en el periodo 1945-1973. Si el empleo de la planificación indicativa es un rasgo común y relevante en casi todos estos países, durante ese periodo, esa institución por sí sola podría servir para establecer la existencia de una variedad diferenciada y significativa del sistema económico capitalista o de economía de mercado: las economías de mercado con planificación indicativa. Además se presentarán los motivos que explican el surgimiento y desaparición de esta institución en esos países y los resultados obtenidos.

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-beta 3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM.

Evaluación del estándar de construcción Passivhaus y su aplicación en el ámbito climático de la Comunidad Autónoma Vasca y la Comunidad Foral Navarra. El caso de la vivienda colectiva de protección oficial

493 p.