Craniosynostosis in Pycnodysostosis: Broadening the Spectrum of the Cranial Flat Bone Abnormalities


Autoria(s): BERTOLA, Debora; AMARAL, Cassio; KIM, Chong; ALBANO, Lilian; AGUENA, Meire; PASSOS-BUENO, Maria Rita
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2010

Resumo

Pycnodysostosis is a rare autosomal recessive skeletal dysplasia caused by the absence of active cathepsin K, which is a lysosomal cysteine protease that plays a role in degrading the organic matrix of bones, acting in bone resorption and bone remodeling. The disease is primarily characterized by osteosclerosis, bone fragility, short stature, acro-osteolysis, and delayed closure of the cranial sutures. A differing feature, cranial synostosis, has occasionally been described in this disorder. We reviewed six unrelated patients with pycnodysostosis (mean age of 10 years and 4 months) in order to evaluate the presence of craniosynostosis. In addition to the typical findings of the condition, they all presented premature fusion of the corona! suture. Although none of them showed signs of cranial hypertension, one patient had had the craniosynostosis surgically corrected previously. These data suggest that the cranial sutures in pycnodysostosis can display contradictory features: wide cranial sutures, which are commonly described, and craniosynostosis. The clinical impact of this latter finding still remains to be elucidated. Further studies are necessary to address more precisely the role of cathepsin K in suture patency. (C) 2010 Wiley-Liss, Inc.

Identificador

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, v.152A, n.10, p.2599-2603, 2010

1552-4825

http://producao.usp.br/handle/BDPI/28674

10.1002/ajmg.a.33609

http://dx.doi.org/10.1002/ajmg.a.33609

Idioma(s)

eng

Publicador

WILEY-LISS

Relação

American Journal of Medical Genetics Part A

Direitos

restrictedAccess

Copyright WILEY-LISS

Palavras-Chave #pycnodysostosis #cathepsin K #craniosynostosis #K-DEFICIENT MICE #LONG-BONE #CATHEPSIN #SUTURE #PYKNODYSOSTOSIS #OSTEOPETROSIS #DEGRADATION #OSTEOCLAST #RESORPTION #HEMATOMA #Genetics & Heredity
Tipo

article

original article

publishedVersion