Yerba Mate (Ilex paraguariensis) Aqueous Extract Decreases Intestinal SGLT1 Gene Expression but Does Not Affect Other Biochemical Parameters in Alloxan-Diabetic Wistar Rats
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2008
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Resumo |
Yerba mate (Ilex paraguariensis) is rich in polyphenols, especially chlorogenic acids. Evidence suggests that dietary polyphenols could play a role in glucose absorption and metabolism. The aim of this study was to evaluate the antidiabetic properties of yerba mate extract in alloxan-induced diabetic Wistar rats. Animals (n = 41) were divided in four groups: nondiabetic control (NDC, n = 10), nondiabetic yerba mate (NDY, n = 10), diabetic control (DC, n = 11), and diabetic yerba mate (NDY, n = 10). The intervention consisted in the administration of yerba mate extract in a 1 g extract/kg body weight dose for 28 days; controls received saline solution only. There were no significant differences in serum glucose, insulin, and hepatic glucose-6-phosphatase activity between the groups that ingested yerba mate extract (NDY and DY) and the controls (NDC and DC). However, the intestinal SGLT1 gene expression was significantly lower in animals that received yerba mate both in upper (p = 0.007) and middle (p < 0.001) small intestine. These results indicate that bioactive compounds present in yerba mate might be capable of interfering in glucose absorption, by decreasing SGLT1 expression. Fundacao de Amparo A Pesquisa do Estado de Sao Paulo (FAPESP) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) |
Identificador |
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.56, n.22, p.10527-10532, 2008 0021-8561 http://producao.usp.br/handle/BDPI/26636 10.1021/jf8021404 |
Idioma(s) |
eng |
Publicador |
AMER CHEMICAL SOC |
Relação |
Journal of Agricultural and Food Chemistry |
Direitos |
restrictedAccess Copyright AMER CHEMICAL SOC |
Palavras-Chave | #Ilex paraguariensis #polyphenols #chlorogenic acid #diabetes mellitus #glucose-6-phosphatase #SGLT1 #BRUSH-BORDER MEMBRANE #CHLOROGENIC ACID #GREEN TEA #GLUCOSE-6-PHOSPHATE TRANSLOCASE #ANTIOXIDANT ACTIVITY #PHENOLIC ANTIOXIDANTS #DENSITY-LIPOPROTEIN #GLUCOSE-ABSORPTION #CAMELLIA-SINENSIS #ARDISIA-COMPRESSA #Agriculture, Multidisciplinary #Chemistry, Applied #Food Science & Technology |
Tipo |
article original article publishedVersion |