39 resultados para praca
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In 2011 the GSB/USB caving group of Bologna has discovered, in the southern fossil branches of Govjestica cave (Valle di Praça, Bosnia) a fossil deposit of vertebrates containing bones of Ursus spelaeus, Capra ibex, Cricetulus migratorius and Microtus. On the basis of the U/Th ages of the bones, teeth and carbonate flowstone covering the fossils (60 ka), datings carried out in the laboratories of U-Series at Bologna, and on the disposition of the bones, a past connection between Govjestica and the nearby Banja Stjena cave is hypothesised. The closure of this passage has occurred suddenly through a collapse that has forced the last cave bears awakened from their winter sleep to stay blocked in Govjestica, and die. The connecting passage has later been covered with calcite flowstones and is no longer visible. This hypothesis is sustained by the rather scarce number of skeletons of cave bears found in Govjestica (a dozen of skulls against the often large amounts of cave bears found in similar caves): Govjestica cave, and especially the Room of the Bones in its southern part, has been used by cave bears only for a couple of centuries before these parts became inaccessible. Furthermore, the entrance of Banja Stjena cave was probably located close to or at the level of the Praça river, that has excavated its thalweg for around 20 metres in the last 60 ka.
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Majer Bałaban
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Includes bibliographical references.
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Certain areas of the city of Sao Paulo, as many others around the world, including in Lisbon, Barcelona and Buenos Aires, have been going through a process of requalification, in special the ones commonly known as old and/or traditional city. Regarding Sao Paulo, some exceptional actions have been taken downtown with investments in rehabilitation/requalification of areas that concentrated the historical, urbanistic and cultural heritages, such as Praca da S and its cathedral, as well as the revaluation/rehabilitation projects of other squares like Praca da Republica, other areas as the previously called Cracolandia (due to high consumption/deal of crack), known today as Nova Luz, besides propositions to reevaluate areas already modified, such as Vale do Anhangabau. In all propositions to modify sites, it is firstly underlined its deterioration, litter and the presence of low-income populations (passer-bys, street vendors or residents), generally stigmatized as ""potential suspects"", emphasizing danger and lack of security in those places. This belief, which has become consensual, results in that: public as well as private companies promote the rehabilitation of the areas basing their reasoning in the necessity of adding value to the existing urban heritage, although, as it will be discussed in this paper, part of this heritage might be destroyed in this very process, under the allegation that upon completion, the action would allow the social, cultural and economical revaluation/requalification of the area. This paper is intended to provide a contribution to this discussion.
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W artykule zastosowano metody analizy skupień z zakresu statystyki wielowymiarowej do badania okresu kryzysu finansowego lat 2007-2013. Zgodnie z tymi algorytmami grupowano spready pomiędzy stopami rynku międzybankowego a OIS. Przeprowadzono dyskusję nad możliwością zastosowania tej metody do generowania ram czasowych różnych okresów kryzysów finansowych. Analiza skupień umożliwiła poczynienie nowych obserwacji na temat kryzy subprime i występującego po nim kryzysu zadłużeniowego. Praca nawiązuje do wcześniejszej publikacji autorki. Uwzględnia inne dane, inny okres kryzysu i zmodyfikowaną metodologię – zamiast podziału próby na lata, podział na okresy równej długości. Dzięki temu nie skraca się znacząco szeregów i nie traci się dużej części informacji.
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14
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Przełom XX i XXI wieku jest okresem fundamentalnych przemian społeczno-gospodarczych i instytucjonalnych w Europie Środkowo-Wschodniej połączonych z przemianami demograficznymi. Przemiany te pociągają za sobą zmianę wielu paradygmatów w naukach przestrzenno-ekonomicznych i praktyce planistyczno-decyzyjnej. Stwierdzenie to odnosi się m.in. do procesu kurczenia się miast (urban shrinkage), tj. długookresowego spadku liczby ludności powiązanego z kryzysem lokalnej gospodarki i narastającymi problemami społecznymi. Proces ten, występujący wcześniej w niektórych miastach (najczęściej starych ośrodkach przemysłowych) Europy Zachodniej i Stanów Zjednoczonych, przybrał po 1990 r. szczególnie duże rozmiary w postkomunistycznych krajach Europy Środkowo-Wschodniej. Pojawiają się zatem nowe wyzwania, dotyczące z jednej strony potrzeby identyfikacji skali, tempa, form kurczenia się miast i ich przestrzennego zróżnicowania, z drugiej strony – rewizji dotychczasowych polityk miejskich, ukierunkowanych najczęściej na paradygmat wzrostu. Te przesłanki powodują, że kurczące się miasta stają się przedmiotem wielu dyskusji naukowych i praktycznych oraz międzynarodowych projektów badawczych. Niniejsza publikacja jest pokłosiem jednego z takich projektów o akronimie CIRES (Cities Regrowing Smaller. Fostering Knowledge on Regeneration Strategies in Shrinking Cities across Europe - Propagowanie wiedzy na temat strategii regeneracji w kurczących się miastach Europy), realizowanego w ramach Akcji COST, tj. Europejskiego Programu Współpracy w Dziedzinie Badań Naukowo-Technicznych. W projekcie tym, który zakończył się w 2013 r., uczestniczyli przedstawiciele wielu dyscyplin naukowych z 26 państw, w tym redaktor naukowy i autorzy kilku rozdziałów tej książki. Celem publikacji jest upowszechnienie wyników projektu CIRES w Polsce odniesionych przede wszystkim do regionu Europy Środkowo-Wschodniej. Książka ta jest dziełem, w którego przygotowaniu brało udział 30 autorów z kraju i zagranicy. Zespół autorów wyraża przekonanie, że publikacja ta stanie się głosem w dyskusji na temat jednego z ważnych procesów określających obecną sytuację wielu miast Polski, Europy i świata.
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Wydział Filologii Polskiej i Klasycznej: Instytut Filologii Polskiej
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Wydział Historyczny
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Topical photodynamic therapy (PDT) has been applied to almost all types of nonmelanoma skin cancer and numerous superficial benign skin disorders. Strategies to improve the accumulation of photosensitizer in the skin have been studied in recent years. Although the hydrophilic phthalocyanine zinc compound, zinc phthalocyanine tetrasulfonate (ZnPcSO4) has shown high photodynamic efficiency and reduced phototoxic side effects in the treatment of brain tumors and eye conditions, its use in topical skin treatment is currently limited by its poor skin penetration. In this study, nanodispersions of monoolein (MO)-based liquid crystalline phases were studied for their ability to increase ZnPcSO4 uptake by the skin. Lamellar, hexagonal and cubic crystalline phases were prepared and identified by polarizing light microscopy, and the nanodispersions were analyzed by dynamic light scattering. In vitro skin penetration studies were performed using a Franz's cell apparatus, and the skin uptake was evaluated in vivo in hairless mice. Aqueous dispersions of cubic and hexagonal phases showed particles of nanometer size, approximately 224 +/- 10 nm and 188 +/- 10 nm, respectively. In vitro skin retention experiments revealed higher fluorescence from the ZnPcSO4 in deeper skin layers when this photosensitizer was loaded in the hexagonal nanodispersion system when compared to both the cubic phase nanoparticles and the bulk crystalline phases (lamellar, cubic and hexagonal). The hexagonal nanodispersion showed a similar penetration behavior in animal tests. These results are important findings, suggesting the development of MO liquid crystal nanodispersions as potential delivery systems to enhance the efficacy of topical PDT.
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To assess topical delivery studies of glycoalkaloids, an analytical method by HPLC-UV was developed and validated for the determination of solasonine (SN) and solamargine (SM) in different skin layers, as well as in a topical formulation. The method was linear within the ranges 0.86 to 990.00 mu g/mL for SN and 1.74 to 1000.00 mu g/mL for SM (r = 0.9996). Moreover, the recoveries for both glycoalkaloids were higher than 88.94 and 93.23% from skin samples and topical formulation, respectively. The method developed is reliable and suitable for topical delivery skin studies and for determining the content of SN and SM in topical formulations.
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The objective of this cross-sectional study was to characterize the manifestations of self-reported urinary incontinence in the postpartum period. We interviewed 288 women who were clients of a teaching health center in Sao Paulo, between the months of January and August of 2009. The data showed that among the 71 incontinent women (24.6%), 44 (62%) reported stress urinary incontinence, 65 (91.5%) were aware of urine leakage, 33 women (46.5%) experienced urine loss more than once a week, and 24 (33.8%) reported persistent urinary incontinence at the time of interview. The severity classified as moderate urinary incontinence was identified in 53 women (74.7%). The findings highlight the importance of studies on urinary incontinence in the postpartum period, as well as approaching this issue in education and health care interventions with women in the reproductive stage.
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Solanum lycocarpum (Solanaceae) is native to the Brazilian Cerrado. Fruits of this species contain the glycoalkaloids solasonine (SN) and solamargine (SM), which display antiparasitic and anticancer properties. A method has been developed for the extraction and HPLC-UV analysis of the SN and SM in different parts of S. lycocarpum, mainly comprising ripe and unripe fruits, leaf, and stem. This analytical method was validated and gave good detection response with linearity over a dynamic range of 0.77-1000.00 mu g mL(-1) and recovery in the range of 80.92-91.71%, allowing a reliable quantitation of the target compounds. Unripe fruits displayed higher concentrations of glycoalkaloids (1.04% +/- 0.01 of SN and 0.69% +/- 0.00 of SM) than the ripe fruits (0.83% +/- 0.02 of SN and 0.60% +/- 0.01 of SM). Quantitation of glycoalkaloids in the alkaloidic extract gave 45.09% +/- 1.14 of SN and 44.37% +/- 0.60 of SM, respectively.
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With special reference to India.
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"Praca odznaczona nagroda̧ im. J.U. Niemciewicza."