Irradiation uniformity at the Laser MegaJoule facility in the context of the shock ignition scheme

The use of the Laser MegaJoule facility within the shock ignition scheme has been considered. In the first part of the study, one-dimensional hydrodynamic calculations were performed for an inertial confinement fusion capsule in the context of the shock ignition scheme providing the energy gain and an estimation of the increase of the peak power due to the reduction of the photon penetration expected during the high-intensity spike pulse. In the second part, we considered a Laser MegaJoule configuration consisting of 176 laser beams that have been grouped providing two different irradiation schemes. In this configuration the maximum available energy and power are 1.3 MJ and 440 TW. Optimization of the laser?capsule parameters that minimize the irradiation non-uniformity during the first few ns of the foot pulse has been performed. The calculations take into account the specific elliptical laser intensity profile provided at the Laser MegaJoule and the expected beam uncertainties. A significant improvement of the illumination uniformity provided by the polar direct drive technique has been demonstrated. Three-dimensional hydrodynamic calculations have been performed in order to analyse the magnitude of the azimuthal component of the irradiation that is neglected in twodimensional hydrodynamic simulations.

Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase

AIMS/HYPOTHESIS:

The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period.

METHODS:

All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture-recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied.

RESULTS:

Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half.

CONCLUSIONS/INTERPRETATION:

The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted.

Temperature non-uniformity in distributed temperature sensors

A study is presented of the effects of temperature non-uniformity in a distributed temperature sensor based on the temperature dependence of Brillouin gain in an optical fibre. The form of the Brillouin gain profile for a given temperature distribution is measured and successfully modelled.

Temperature non-uniformity in distributed temperature sensors

A study is presented of the effects of temperature non-uniformity in a distributed temperature sensor based on the temperature dependence of Brillouin gain in an optical fibre. The form of the Brillouin gain profile for a given temperature distribution is measured and successfully modelled.

Beam smoothing by lens array with spectral dispersion

A scheme of combining technology of lens array (LA) and smoothing by spectral dispersion (SSD) is introduced to improve the irradiation uniformity in laser fusion based on the earlier works on LA. The feasibility of the scheme is also analyzed by numerical simulation. It shows that a focal pattern with flat-top and sharp-edge profile could be obtained, and the irradiation nonuniformity can fall down from 14% with only LA to 3% with both SSD and LA. And this smoothing scheme is depended less on the incidence comparing to other smoothing methods. The preliminary experiment has demonstrated its effectiveness. (c) 2006 Elsevier B.V. All rights reserved.

谱色散平滑与透镜列阵联用实现均匀照明

为满足激光惯性约束聚变中靶面激光辐照不均匀性低于5%的要求, 在目前使用透镜列阵基础上, 提出了谱色散平滑与透镜列阵联用方案, 对其进行数值计算并分析其平滑效果和应用可行性。结果表明:焦斑的不均匀性从单独使用透镜列阵时的14%降低到与谱色散平滑结合后的3%;对焦斑点功率谱的分析表明谱色散平滑通过抑制焦斑中高频的频谱强度达到平滑效果。该方案可以进一步提高焦斑平滑效果, 计算结果对实际应用有着重要的参考意义。

Conventional in vivo irradiation procedures are insufficient to accurately determine tumor responses to non-uniform radiation fields

Purpose: To determine differences in overall tumor responses measured by volumetric assessment and bioluminescence imaging (BLI) following exposure to uniform and non-uniform radiation fields in an ectopic prostate tumor model.

Materials and methods: Bioluminescent human prostate tumor xenografts were established by subcutaneous implantation into male mice. Tumors were irradiated with uniform or non-uniform field configurations using conventional in vivo irradiation procedures performed using a 225 kVp generator with custom lead shielding. Tumor responses were measured using Vernier calipers and by BLI using an in vivo imaging system. Survival was defined as the time to quadroupling of pre-treatment tumor volume. 

Results: The correlation between BLI and tumor volume measurements was found to be different for un-irradiated (R = 0.61), uniformly irradiated (R = 0.34) and partially irradiated (R = 0.30) tumors. Uniformly irradiated tumors resulted in an average tumor growth delay of 60 days with median survival of 75 days, compared to partially irradiated tumors which showed an average growth delay of 24 days and median survival of 38 days. 

Conclusions: Correlation between BLI and tumor volume measurements is lower for partially irradiated tumors than those exposed to uniform dose distributions. The response of partially irradiated tumors suggests non-uniformity in response beyond physical dose distribution within the target volume. Dosimetric uncertainty associated with conventional in vivo irradiation procedures prohibits their ability to accurately determine tumor response to non-uniform radiation fields and stresses the need for image guided small animal radiation research platforms.

Optimizations for the uniformity of the non-volatile volume grating in doubly doped LiNbO3 crystals

The formation of the non-uniformity of the non-volatile volume grating in doubly doped LiNbO3 crystals is studied in detail. We find that the non-uniformity of the grating is mainly caused by strong ultraviolet light absorption, and the average saturation space-charge field is small and the diffraction efficiency is low as a result of the non-uniformity of the grating. In order to optimize the uniformity of the grating, we propose the recording scheme by using two sensitizing beams simultaneously from the two opposite sides of the crystals. Theoretical simulations and experimental verifications are performed. Results show that the well uniformed grating with high diffraction efficiency can be obtained by using this optimization scheme. (c) 2004 Elsevier B.V. All rights reserved.

Effect of non-uniform magnetic field on crystal growth by floating-zone method in microgravity

The magnetic damping effect of the non-uniform magnetic field on the floating-zone crystal growth process in microgravity is studied by numerical simulation. The results show that the non-uniform magnetic field with designed configuration can effectively reduce the flow near the free surface and then in the melt zone. At the same time, the designed magnetic field can improve the impurity concentration non-uniformity along the solidification interface. The primary principles of the magnetic field configuration design are also discussed.

Layer uniformity of glancing angle deposition

Some results of an investigation on the layer thickness uniformity of glancing angle deposition are presented. A zirconia monolayer has been deposited by glancing angle deposition to analyze the layer thickness uniformity. The experimental results indicate that the thickness variation over the substrate is less than 0. 1%, which is considered as good uniformity. It is found that the non-uniformity of experimental results is larger than that of the theoretical results. (c) 2005 Elsevier Ltd. All rights reserved.

Non-Uniform Reductions

We study properties of non-uniform reductions and related completeness notions. We strengthen several results of Hitchcock and Pavan and give a trade-off between the amount of advice needed for a reduction and its honesty on NEXP. We construct an oracle relative to which this trade-off is optimal. We show, in a more systematic study of non-uniform reductions, that among other things non-uniformity can be removed at the cost of more queries. In line with Post's program for complexity theory we connect such 'uniformization' properties to the separation of complexity classes.