A dynamic causal model of the coupling between pulse stimulation and neural activity

We present a dynamic causal model that can explain context-dependent changes in neural responses, in the rat barrel cortex, to an electrical whisker stimulation at different frequencies. Neural responses were measured in terms of local field potentials. These were converted into current source density (CSD) data, and the time series of the CSD sink was extracted to provide a time series response train. The model structure consists of three layers (approximating the responses from the brain stem to the thalamus and then the barrel cortex), and the latter two layers contain nonlinearly coupled modules of linear second-order dynamic systems. The interaction of these modules forms a nonlinear regulatory system that determines the temporal structure of the neural response amplitude for the thalamic and cortical layers. The model is based on the measured population dynamics of neurons rather than the dynamics of a single neuron and was evaluated against CSD data from experiments with varying stimulation frequency (1–40 Hz), random pulse trains, and awake and anesthetized animals. The model parameters obtained by optimization for different physiological conditions (anesthetized or awake) were significantly different. Following Friston, Mechelli, Turner, and Price (2000), this work is part of a formal mathematical system currently being developed (Zheng et al., 2005) that links stimulation to the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal through neural activity and hemodynamic variables. The importance of the model described here is that it can be used to invert the hemodynamic measurements of changes in blood flow to estimate the underlying neural activity.

What will affect software reuse: a causal model analysis

Software reuse is an important topic due to its potential benefits in increasing product quality and decreasing cost. Although more and more people are aware that not only technical issues, but also nontechnical issues are important to the success of software reuse, people are still not certain which factors will have direct effect on the success of reuse. In this paper, we applied a causal discovery algorithm to the software reuse survey data [2]. Ensemble strategy is incorporated to locate a probable causal model structure for software reuse, and find all those factors which have direct effect on the success of reuse. Our discovery results reinforced some conclusions of Morisio et al. and found some new conclusions which might significantly improve the odds of a reuse project succeeding.

Accelerating linear causal model discovery using hoeffding bounds

Efficiently inducing precise causal models accurately reflecting given data sets is the ultimate goal of causal discovery. The algorithms proposed by Dai et al. has demonstrated the ability of the Minimum Message Length (MML) principle in discovering Linear Causal Models from training data. In order to further explore ways to improve efficiency, this paper incorporates the Hoeffding Bounds into the learning process. At each step of causal discovery, if a small number of data items is enough to distinguish the better model from the rest, the computation cost will be reduced by ignoring the other data items. Experiments with data set from related benchmark models indicate that the new algorithm achieves speedup over previous work in terms of learning efficiency while preserving the discovery accuracy.

Linear causal model discovery using the MML criterion

Determining the causal structure of a domain is a key task in the area of Data Mining and Knowledge Discovery.The algorithm proposed by Wallace et al. [15] has demonstrated its strong ability in discovering Linear Causal Models from given data sets. However, some experiments showed that this algorithm experienced difficulty in discovering linear relations with small deviation, and it occasionally gives a negative message length, which should not be allowed. In this paper, a more efficient and precise MML encoding scheme is proposed to describe the model structure and the nodes in a Linear Causal Model. The estimation of different parameters is also derived. Empirical results show that the new algorithm outperformed the previous MML-based algorithm in terms of both speed and precision.

Discovering linear causal model from incomplete data

One common drawback in algorithms for learning Linear Causal Models is that they can not deal with incomplete data set. This is unfortunate since many real problems involve missing data or even hidden variable. In this paper, based on multiple imputation, we propose a three-step process to learn linear causal models from incomplete data set. Experimental results indicate that this algorithm is better than the single imputation method (EM algorithm) and the simple list deletion method, and for lower missing rate, this algorithm can even find models better than the results from the greedy learning algorithm MLGS working in a complete data set. In addition, the method is amenable to parallel or distributed processing, which is an important characteristic for data mining in large data sets.

Encoding, ensemble and accelerating strategies for linear causal model discovery

This thesis made outstanding contribution in automating the discovery of linear causal models. It introduced a highly efficient discovery algorithm, which implements new encoding, ensemble and accelerating strategies. Theoretic research and experimental work showed that this new discovery algorithm outperforms the previous system in both accuracy and efficiency.

Reliable knowledge discovery with a minimal causal model inducer

This paper presents a Minimal Causal Model Inducer that can be used for the reliable knowledge discovery. The minimal-model semantics of causal discovery is an essential concept for the identification of a best fitting model in the sense of satisfactory consistent with the given data and be the simpler, less expressive model. Consistency is one of major measures of reliability in knowledge discovery. Therefore to develop an algorithm being able to derive a minimal model is an interesting topic in the are of reliable knowledge discovery. various causal induction algorithms and tools developed so far can not guarantee that the derived model is minimal and consistent. It was proved the MML induction approach introduced by Wallace, Keven and Honghua Dai is a minimal causal model learner. In this paper, we further prove that the developed minimal causal model learner is reliable in the sense of satisfactory consistency. The experimental results obtained from the tests on a number of both artificial and real models provided in this paper confirm this theoretical result.

A causal model of mathematics performance in early adolescence: the role of sex

Using path analysis, the present investigation was done to clarify possible causal linkages among general scholastic aptitude, academic achievement in mathematics, self-concept of ability, and performance on a mathematics examination. Subjects were 122 eighth-grade students who completed a mathematics examination as well as a measure of self-concept of ability. Aptitude and achievement measures were obtained from school records. Analysis showed sex differences in prediction of performance on the mathematics examination. For boys, this performance could be predicted from scholastic aptitude and previous achievement in mathematics. For girls, performance only could be predicted from previous achievement in mathematics. These results indicate that the direction, strength, and magnitude of relations among these variables differed for boys and girls, while mean levels of performance did not.

The evaluation of a causal model of job performance : the relation of job experience and general mental ability to job performance /

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Cervical cancer precursors and hormonal contraceptive use in HIV-positive women: application of a causal model and semi-parametric estimation methods.

OBJECTIVE: To demonstrate the application of causal inference methods to observational data in the obstetrics and gynecology field, particularly causal modeling and semi-parametric estimation. BACKGROUND: Human immunodeficiency virus (HIV)-positive women are at increased risk for cervical cancer and its treatable precursors. Determining whether potential risk factors such as hormonal contraception are true causes is critical for informing public health strategies as longevity increases among HIV-positive women in developing countries. METHODS: We developed a causal model of the factors related to combined oral contraceptive (COC) use and cervical intraepithelial neoplasia 2 or greater (CIN2+) and modified the model to fit the observed data, drawn from women in a cervical cancer screening program at HIV clinics in Kenya. Assumptions required for substantiation of a causal relationship were assessed. We estimated the population-level association using semi-parametric methods: g-computation, inverse probability of treatment weighting, and targeted maximum likelihood estimation. RESULTS: We identified 2 plausible causal paths from COC use to CIN2+: via HPV infection and via increased disease progression. Study data enabled estimation of the latter only with strong assumptions of no unmeasured confounding. Of 2,519 women under 50 screened per protocol, 219 (8.7%) were diagnosed with CIN2+. Marginal modeling suggested a 2.9% (95% confidence interval 0.1%, 6.9%) increase in prevalence of CIN2+ if all women under 50 were exposed to COC; the significance of this association was sensitive to method of estimation and exposure misclassification. CONCLUSION: Use of causal modeling enabled clear representation of the causal relationship of interest and the assumptions required to estimate that relationship from the observed data. Semi-parametric estimation methods provided flexibility and reduced reliance on correct model form. Although selected results suggest an increased prevalence of CIN2+ associated with COC, evidence is insufficient to conclude causality. Priority areas for future studies to better satisfy causal criteria are identified.

Analyse de sensibilité de l’effet d’un programme de prévention avec randomisation : application de trois techniques d’appariement pour balancer les groupes contrôle et expérimental : distance de Mahanalobis, score de propension et algorithme génétique

Les analyses effectuées dans le cadre de ce mémoire ont été réalisées à l'aide du module MatchIt disponible sous l’environnent d'analyse statistique R. / Statistical analyzes of this thesis were performed using the MatchIt package available in the statistical analysis environment R.

Developing a model of technology appropriation: A Marxian perspective

This paper explores the philosophical origins of appropriation of Information Systems (IS) using Marxian and other socio-cultural theory. It provides an in-depth examination of appropriation and its application in extant IS theory. We develop a three-tier model using Marx’s foundational concepts and from this generate four propositions that we test in an empirical example of IS in anesthesia. Using Marxian theory, this paper seeks common ground among existing theories of technology appropriation in IS research. This work contributes to IS research by (1) opening philosophical discussions on appropriation and the human ↔ technology nexus, (2) drawing on these varying perspectives to propose a general conceptualization of technology appropriation and (3) providing a starting point towards a general causal model of technology appropriation.

A Marxian model of technology appropriation

This paper explores the philosophical roots of appropriation within Marx's theories and socio-cultural studies in an attempt to seek common ground among existing theories of technology appropriation in IS research. Drawing on appropriation perspectives from Adaptive Structuration Theory, the Model of Technology Appropriation and the Structurational Model of Technology for comparison, we aim to generate a Marxian model that provides a starting point toward a general causal model of technology appropriation. This paper opens a philosophical discussion on the phenomenon of appropriation in the IS community, directing attention to foundational concepts in the human-technology nexus using ideas conceived by Marx.

STOF Model : critical design issues and critical success factors

In this chapter we will make the transition towards the design of business models and the related critical issues. We develop a model that helps us understand the causalities that play a role in understanding the viability and feasibility of the business models, i.e. long-term profitability and market adoption. We argue that designing viable business models requires balancing the requirements and interests of the actors involved, within and between the various business model domains. Requirements in the service domain guide the design choices in the technology domain, which in turn affect network formation and the financial arrangements. It is important to understand the Critical Design Issues (CDIs) involved in business models and their interdependencies. In this chapter, we present the Critical Design Issues involved in designing mobile service business models, and demonstrate how they are linked to the Critical Success Factors (CSFs) with regard to business model viability. This results in a causal model for understanding business model viability, as well as providing grounding for the business model design approach outlined in Chapter 5.