Reduction of DDHQ and TCC esters by NaBH4-its specificity in the presence of Alkyl/Aryl esters

DDHQ/TCC esters 3a–f, 7a–g were prepared either by oxidation of spiroketones 1 with DDQ/Image -chloranil or by condensation of acid chloride with DDHQ/TCC. NaBH4 reduction of unsaturated DDHQ 3a–b and TCC 7a–c esters gave the corresponding allylic alcohols in good yield without any observable 1,4-addition products. Reduction of saturated esters 3e, 7d, gave the corresponding alcohols. Alkyl esters 5 and 6, methyl benzoate and phenyl benzoate remained unaffected under these reduction conditions. In the reduction of compound 7e containing both alkyl and TCC esters, TCC ester is selectively reduced. Reduction of TCC mono esters 7f–g gave the lactones. The observed facile reduction has been rationalised.

Screening of ARHSP-TCC Patients Expands the Spectrum of SPG11 Mutations and Includes a Large Scale Gene Deletion

Autosomal recessive spastic paraplegia with thinning of corpus callosum (ARHSP-TCC) is a complex form of HSP initially described in Japan but subsequently reported to have a worldwide distribution with a particular high frequency in multiple families from the Mediterranean basin. We recently showed that ARHSP-TCC is commonly associated with mutations in SPG11/KIAA1840 on chromosome 15q. We have now screened a collection of new patients mainly originating from Italy and Brazil, in order to further ascertain the spectrum of mutations in SPG11, enlarge the ethnic origin of SPG11 patients, determine the relative frequency at the level of single Countries (i.e., Italy), and establish whether there is one or more common mutation. In 25 index cases we identified 32 mutations; 22 are novel, including 9 nonsense, 3 small deletions, 4 insertions, 1 in/del, 1 small duplication, 1 missense, 2 splice-site, and for the first time a large genomic rearrangement. This brings the total number of SPG11 mutated patients in the SPATAX collection to 111 cases in 44 families and in 17 isolated cases, from 16 Countries, all assessed using homogeneous clinical criteria. While expanding the spectrum of mutations in SPG11, this larger series also corroborated the notion that even within apparently homogeneous population a molecular diagnosis cannot be achieved without full gene sequencing. (C) 2008 Wiley-Liss, Inc.

TCC também é notícia: estudo de caso da Agência Experimental de Divulgação Científica da Universidade Municipal de São Caetano do Sul (USCS)

Artigo apresentado em congresso nacional de comunicação

Relation between Tcc,bb and Xc,b from QCD.

We have studied, using double ratio of QCD (spectral) sum rules, the ratio between the masses of Tcc and X(3872) assuming that they are respectively described by the D−D∗ and D− ¯D∗ molecular currents. We found (within our approximation) that the masses of these two states are almost degenerate. Since the pion exchange interaction between these mesons is exactly the same, we conclude that if the observed X(3872) meson is a D ¯D∗ + c.c. molecule, then the DD∗ molecule should also exist with approximately the same mass. An extension of the analysis to the b-quark case leads to the same conclusion. We also study the SU(3) breakings for the T s Q Q /TQ Q mass ratios. Motivated by the recent Belle observation of two Zb states, we revise our determination of Xb by combining results from exponential and FESR sum rules.

Organizational maintenance : telelphone terminal AN/TCC-7.

"April 1958."

Telephone repeater AN/TCC-8 and telephone repeater AN/TCC-21, organizational maintenance.

"March 1958."

Direct support and general support maintenance manual (including repair parts and special tools list) : converters, telegraph-telephone signal CV-425/U, (part of terminal telegraph-telephone AN/TCC-29).

Includes index.

Organizational, direct support, and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools) for terminal sets, telephone AN/TCC-69 (NSN 5805-00-089-6253) and AN/TCC-60 (5805-00-877-8740).

Includes index.

Operator's, organizational, direct support, and general support maintenance manual : telephone terminal sets AN/TCC-73(V)1, (NSN 5805-00-134-5405), AN/TCC-73(V)2, (NSN 5805-00-134-5404), AN/TCC-73A(V)1, (NSN 5805-01-102-0185) and AN/TCC-73A(V)2, (NSN 5805-01-135-7070) in shelter, electrical equipment S-419B/TCC-73(V), (NSN 5410-01-098-2393).

"29 April 1983."

Organizational, direct support, and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools) for terminal set, telephone AN/TCC-72, (NSN 5805-00-133-9003).

Includes index.

Hand receipt covering contents of Components of End Item (COEI), Basic Issue Items (BII), and Additional Authorization List (AAL) for telephone terminal sets AN/TCC-73(V)1, (NSN 5805-00-135-5405) ... and AN/TCC-73A(V)2, (NSN 5805-01-135-7070) in shelter, electrical equipment S-419B/TCC-73(V), (NSN 5410-01-098-2393).

"21 September 1983."

Organizational maintenance repair parts and special tools lists for terminal set, telephone AN/TCC-65 (NSN 5805-00-868-8215).

Includes index.

Organizational, direct support, and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools) for terminal set, telephone AN/TCC-61 (NSN 5805-00-877-8741).

"September 1979."

Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer

We have utilized a cross-sectional association approach to investigate sporadic breast cancer. Polymorphisms in 2 candidate genes, ESRalpha and GRL, were examined in an unrelated breast cancer-affected and age-matched control population. Several polymorphic regions within the ESRalpha gene have been identified, and some alleles of these polymorphisms have been found to occur at increased levels in breast-cancer patients. Additionally, variations in GRL have the potential to disrupt cell transcription and may be associated with cancer formation. We analyzed 3 polymorphisms, from codons 10 (TCT to TCC), 325 (CCC to CCG) and 594 (ACA to ACG) of ESRalpha, and a highly polymorphic dinucleotide repeat, D5S207, located within 200 kb of the GRL. When allelic frequencies of the codon 594 (exon 8) ESR polymorphism were compared between affected and unaffected populations, a significant difference was observed (p = 0.005). Results from the D5S207 dinucleotide repeat located near GRL also indicated a significant difference between the tested case and control populations (p = 0.001). Allelic frequencies of the codon 10 and codon 325 ESR polymorphisms were not significantly different between populations (p = 0.152 and 0.181, respectively). Our results indicate that specific alleles of the ESR gene (alpha subtype) and a marker for the GRL gene locus are associated with sporadic breast-cancer development in the tested Caucasian population and justify further investigation of the role of these and other nuclear steroid receptors in the etiology of breast cancer.