Context-specific independence in graphical models

The theme of this thesis is context-speci c independence in graphical models. Considering a system of stochastic variables it is often the case that the variables are dependent of each other. This can, for instance, be seen by measuring the covariance between a pair of variables. Using graphical models, it is possible to visualize the dependence structure found in a set of stochastic variables. Using ordinary graphical models, such as Markov networks, Bayesian networks, and Gaussian graphical models, the type of dependencies that can be modeled is limited to marginal and conditional (in)dependencies. The models introduced in this thesis enable the graphical representation of context-speci c independencies, i.e. conditional independencies that hold only in a subset of the outcome space of the conditioning variables. In the articles included in this thesis, we introduce several types of graphical models that can represent context-speci c independencies. Models for both discrete variables and continuous variables are considered. A wide range of properties are examined for the introduced models, including identi ability, robustness, scoring, and optimization. In one article, a predictive classi er which utilizes context-speci c independence models is introduced. This classi er clearly demonstrates the potential bene ts of the introduced models. The purpose of the material included in the thesis prior to the articles is to provide the basic theory needed to understand the articles.

Handbok för kombinerade sol- och biovärmesystem : Teknik - System - Ekonomi

Handboken beskriver olika solfångarkonstruktioner och solvärmekretsens ingående komponenter och ger en grundlig inblick i ackumulatortankens konstruktion och funktion. I boken finns förslag på systemutformning, olika tekniska lösningar och hur systemen bör styras och regleras. Handboken beskriver i första hand utformning-lösning-styrning av kombinationen sol- och pelletsvärme, men tar även upp solvärme i kombination med vedpannor, värmedrivna vitvaror och värmepumpar. Värmesystem med vattenburen värme är utmärkta att kombinera med solvärme, men det är i de flesta fall enklare att få till bra lösningar vid nyinstallation, än vid komplettering av befintlig anläggning. När solvärme och pelletsvärme ska kombineras finns det många alternativ till systemutformning. Det är viktigt att vattenburna pelletssystem utformas korrekt och kombineras på rätt sätt med solvärme för att komforten ska bli hög och elanvändningen låg. Vattenmantlade pelletskaminer med ett vattenburet värmesystem är extra intressant i kombination med solvärme. När eldningen upphör i samband med att värmebehovet avtar kan solvärmen ta över. En generell slutsats är att konventionella svenska pelletspannor med inbyggd varmvattenberedning inte är lämpliga i kombination med solvärmesystem. Den typen av bränslepannor ger komplicerade systemlösningar, höga värmeförluster och det är svårt att åstadkomma en tillräckligt bra temperaturskiktning i ackumulatortanken om varmvattenberedning sker i pannan. Solvärme för varmvattenberedning kan vara ett enkelt och bra komplement till pelletskaminer som genererar varmluft. För solvärmesystem är det viktigt att kraftig temperaturskiktning erhålls när värmelagret laddas ur. Det betyder att ackumulatortankens (eller varmvattenberedarens) nedre vattenvolym ska kylas ner till temperaturer som ligger nära ingående kallvattentemperatur. Ackumulatortankens mellersta del bör kylas till samma temperatur som radiatorreturen. Vid design av solfångarkretsen måste överhettning och stagnation kunna klaras utan risk för glykolnedbrytning eller andra skador på värmebärare eller rörkrets (och andra komponenter i kretsen). Partiell förångning minskar risken för att glykolen skadas då solfångaren når höga stagnationstemperaturer. Solfångarens glykolblandning tillåts koka (förångas) på ett kontrollerat sätt så att endast ånga blir kvar i solfångaren. Vätskevolymen i solfångaren samlas upp i ett större expansionskärl och systemet återfylls när vätskan kondenserar. Dränerande solfångarsystem med enbart vatten är ett möjligt alternativ till konventionella solfångare. De kräver en större noggrannhet vid installationen, så att sönderfrysning undviks. Dränerande systemlösningar är relativt ovanliga i Sverige. Om solfångaren under senhöst-vinter-tidig vår kan arbeta med att förvärma kallvatten från 10 till 20 ºC erhålls en betydligt bättre verkningsgrad på solfångaren (och framför allt ökar värmeutbytet då drifttimmarna ökar väsentligt) än om radiatorreturen (som i bästa fall ligger på temperaturnivån 30 - 40 ºC) ska förvärmas. Därför bör radiatorreturen placeras en bra bit upp från botten i ackumulatortanken och tappvarmvattnet ska förvärmas i en slinga som börjar i tankens botten. Om det finns ett VVC-system måste systemet anslutas på ett speciellt sätt så att ackumulatortankens temperaturskiktning inte störs. En viktig parameter vid ackumulatortankens utformning är att värmeförlusterna hålls låga. Det är viktigt för att klara tappvarmvattenlasten med solvärme under mulna perioder sommartid (men också för att hålla energianvändningen låg). I moderna hus, där ackumulatortanken i regel placeras i bostaden, blir det en komfortfråga att undvika övertemperaturer i det rum där värmelagret placeras. En bra standard på isoleringen (med minimerade värmeförluster) kräver att det finns ett lufttätt skikt över hela isoleringen som dessutom sluter tätt mot röranslutningar. Ofrivillig självcirkulation i anslutande kretsar som kan kyla av och blanda om ackumulatortankens vattenvolym, bör förhindras med backventiler och nedböjning av rören i isolerskiktet eller direkt utanför tanken.

A new histology scoring system for the assessment of the quality of human cartilage repair: ICRS II

A reliable and reproducible method is needed to assess cartilage repair.

Analytical BER performance in differential n-PSK coherent transmission system influenced by equalization enhanced phase noise

Long-haul high speed optical transmission systems are significantly distorted by the interplay between the electronic chromatic dispersion (CD) equalization and the local oscillator (LO) laser phase noise, which leads to an effect of equalization enhanced phase noise (EEPN). The EEPN degrades the performance of optical communication systems severely with the increment of fiber dispersion, LO laser linewidth, symbol rate, and modulation format. In this paper, we present an analytical model for evaluating the performance of bit-error-rate (BER) versus signal-to-noise ratio (SNR) in the n-level phase shift keying (n-PSK) coherent transmission system employing differential carrier phase estimation (CPE), where the influence of EEPN is considered. Theoretical results based on this model have been investigated for the differential quadrature phase shift keying (DQPSK), the differential 8-PSK (D8PSK), and the differential 16-PSK (D16PSK) coherent transmission systems. The influence of EEPN on the BER performance in term of the fiber dispersion, the LO phase noise, the symbol rate, and the modulation format are analyzed in detail. The BER behaviors based on this analytical model achieve a good agreement with previously reported BER floors influenced by EEPN. Further simulations have also been carried out in the differential CPE considering EEPN. The results indicate that this analytical model can give an accurate prediction for the DQPSK system, and a leading-order approximation for the D8PSK and the D16PSK systems.

Mitigation of EEPN in long-haul n-PSK coherent transmission system using modified optical pilot carrier

We present the compensation of the equalization enhanced phase noise (EEPN) in the long-haul n-level phase shift keying (n-PSK) coherent optical transmission system, by employing a scheme of phase modulated optical pilot carrier. © OSA 2013.

Analysis of carrier phase extraction methods in 112-Gbit/s NRZ-PDM-QPSK coherent transmission system

We present a comparative analysis on three carrier phase extraction approaches, including a one-tap normalized least mean square method, a block-average method, and a Viterbi-Viterbi method, in coherent transmission system considering equalization enhanced phase noise. © OSA 2012.

Influence of digital dispersion equalization on phase noise enhancement in coherent optical system

The phase noise enhancement due to digital dispersion equalization is investigated, which indicates that the phase noise from transmitter laser can also interact with the dispersion depending on the choice of digital dispersion compensation methods. © OSA 2012.

Obesity And Inflammation And The Effect On The Hematopoietic System.

Bone marrow is organized in specialized microenvironments known as 'marrow niches'. These are important for the maintenance of stem cells and their hematopoietic progenitors whose homeostasis also depends on other cell types present in the tissue. Extrinsic factors, such as infection and inflammatory states, may affect this system by causing cytokine dysregulation (imbalance in cytokine production) and changes in cell proliferation and self-renewal rates, and may also induce changes in the metabolism and cell cycle. Known to relate to chronic inflammation, obesity is responsible for systemic changes that are best studied in the cardiovascular system. Little is known regarding the changes in the hematopoietic system induced by the inflammatory state carried by obesity or the cell and molecular mechanisms involved. The understanding of the biological behavior of hematopoietic stem cells under obesity-induced chronic inflammation could help elucidate the pathophysiological mechanisms involved in other inflammatory processes, such as neoplastic diseases and bone marrow failure syndromes.

The Value Of The 2005 International Society Of Urological Pathology (isup) Modified Gleason Grading System As A Predictor Of Biochemical Recurrence After Radical Prostatectomy.

To compare time and risk to biochemical recurrence (BR) after radical prostatectomy of two chronologically different groups of patients using the standard and the modified Gleason system (MGS). Cohort 1 comprised biopsies of 197 patients graded according to the standard Gleason system (SGS) in the period 1997/2004, and cohort 2, 176 biopsies graded according to the modified system in the period 2005/2011. Time to BR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter time to recurrence using univariate and multivariate Cox proportional hazards model. Patients in cohort 2 reflected time-related changes: striking increase in clinical stage T1c, systematic use of extended biopsies, and lower percentage of total length of cancer in millimeter in all cores. The MGS used in cohort 2 showed fewer biopsies with Gleason score ≤ 6 and more biopsies of the intermediate Gleason score 7. Time to BR using the Kaplan-Meier curves showed statistical significance using the MGS in cohort 2, but not the SGS in cohort 1. Only the MGS predicted shorter time to BR on univariate analysis and on multivariate analysis was an independent predictor. The results favor that the 2005 International Society of Urological Pathology modified system is a refinement of the Gleason grading and valuable for contemporary clinical practice.

The Applicability Of Ordered Mesoporous Sba-15 And Its Hydrophobic Glutaraldehyde-bridge Derivative To Improve Ibuprofen-loading In Releasing System.

The mesoporous SBA-15 silica with uniform hexagonal pore, narrow pore size distribution and tuneable pore diameter was organofunctionalized with glutaraldehyde-bridged silylating agent. The precursor and its derivative silicas were ibuprofen-loaded for controlled delivery in simulated biological fluids. The synthesized silicas were characterized by elemental analysis, infrared spectroscopy, (13)C and (29)Si solid state NMR spectroscopy, nitrogen adsorption, X-ray diffractometry, thermogravimetry and scanning electron microscopy. Surface functionalization with amine containing bridged hydrophobic structure resulted in significantly decreased surface area from 802.4 to 63.0 m(2) g(-1) and pore diameter 8.0-6.0 nm, which ultimately increased the drug-loading capacity from 18.0% up to 28.3% and a very slow release rate of ibuprofen over the period of 72.5h. The in vitro drug release demonstrated that SBA-15 presented the fastest release from 25% to 27% and SBA-15GA gave near 10% of drug release in all fluids during 72.5 h. The Korsmeyer-Peppas model better fits the release data with the Fickian diffusion mechanism and zero order kinetics for synthesized mesoporous silicas. Both pore sizes and hydrophobicity influenced the rate of the release process, indicating that the chemically modified silica can be suggested to design formulation of slow and constant release over a defined period, to avoid repeated administration.

Electronic And Structural Study Of Pt-modified Au Vicinal Surfaces: A Model System For Pt-au Catalysts.

Two single crystalline surfaces of Au vicinal to the (111) plane were modified with Pt and studied using scanning tunneling microscopy (STM) and X-ray photoemission spectroscopy (XPS) in ultra-high vacuum environment. The vicinal surfaces studied are Au(332) and Au(887) and different Pt coverage (θPt) were deposited on each surface. From STM images we determine that Pt deposits on both surfaces as nanoislands with heights ranging from 1 ML to 3 ML depending on θPt. On both surfaces the early growth of Pt ad-islands occurs at the lower part of the step edge, with Pt ad-atoms being incorporated into the steps in some cases. XPS results indicate that partial alloying of Pt occurs at the interface at room temperature and at all coverage, as suggested by the negative chemical shift of Pt 4f core line, indicating an upward shift of the d-band center of the alloyed Pt. Also, the existence of a segregated Pt phase especially at higher coverage is detected by XPS. Sample annealing indicates that the temperature rise promotes a further incorporation of Pt atoms into the Au substrate as supported by STM and XPS results. Additionally, the catalytic activity of different PtAu systems reported in the literature for some electrochemical reactions is discussed considering our findings.

Inhibitory Effects Of A Cured Antibacterial Bonding System On Viability And Metabolic Activity Of Oral Bacteria.

To evaluate the antimicrobial efficacy of Clearfil SE Protect (CP) and Clearfil SE Bond (CB) after curing and rinsed against five individual oral microorganisms as well as a mixture of bacterial culture prepared from the selected test organisms. Bacterial suspensions were prepared from single species of Streptococcus mutans, Streptococcus sobrinus, Streptococcus gordonii, Actinomyces viscosus and Lactobacillus lactis, as well as mixed bacterial suspensions from these organisms. Dentin bonding system discs (6 mm×2 mm) were prepared, cured, washed and placed on the bacterial suspension of single species or multispecies bacteria for 15, 30 and 60 min. MTT, Live/Dead bacterial viability (antibacterial effect), and XTT (metabolic activity) assays were used to test the two dentin system's antibacterial effect. All assays were done in triplicates and each experiment repeated at least three times. Data were submitted to ANOVA and Scheffe's f-test (5%). Greater than 40% bacteria killing was seen within 15 min, and the killing progressed with increasing time of incubation with CP discs. However, a longer (60 min) period of incubation was required by CP to achieve similar antimicrobial effect against mixed bacterial suspension. CB had no significant effect on the viability or metabolic activity of the test microorganisms when compared to the control bacterial culture. CP was significantly effective in reducing the viability and metabolic activity of the test organisms. The results demonstrated the antimicrobial efficacy of CP both on single and multispecies bacterial culture. CP may be beneficial in reducing bacterial infections in cavity preparations in clinical dentistry.

Blockade Of Renin-angiotensin System Prevents Micturition Dysfunction In Renovascular Hypertensive Rats.

Association between hypertension and bladder symptoms has been described. We hypothesized that micturition dysfunction may be associated with renin-angiotensin system (RAS) acting in urethra. The effects of the anti-hypertensive drugs losartan (AT1 antagonist) and captopril (angiotensin-converting enzyme inhibitor) in comparison with atenolol (β1-adrenoceptor antagonist independently of RAS blockade) have been investigated in bladder and urethral dysfunctions during renovascular hypertension in rats. Two kidney-1 clip (2K-1C) rats were treated with losartan (30 mg/kg/day), captopril (50mg/kg/day) or atenolol (90 mg/kg/day) for eight weeks. Cystometric study, bladder and urethra smooth muscle reactivities, measurement of cAMP levels and p38 MAPK phosphorylation in urinary tract were determined. Losartan and captopril markedly reduced blood pressure in 2K-1C rats. The increases in non-voiding contractions, voiding frequency and bladder capacity in 2K-1C rats were prevented by treatments with both drugs. Likewise, losartan and captopril prevented the enhanced bladder contractions to electrical-field stimulation (EFS) and carbachol, along with the impaired relaxations to β-adrenergic-cAMP stimulation. Enhanced neurogenic contractions and impaired nitrergic relaxations were observed in urethra from 2K-1C rats. Angiotensin II also produced greater urethral contractions that were accompanied by higher phosphorylation of p38 MAPK in urethral tissues of 2K-1C rats. Losartan and captopril normalized the urethral dysfunctions in 2K-1C rats. In contrast, atenolol treatment largely reduced the blood pressure in 2K-1C rats but failed to affect the urinary tract smooth muscle dysfunction. The urinary tract smooth muscle dysfunction in 2K-1C rats takes place by local RAS activation irrespective of levels of arterial blood pressure.

Transmission Of Intra-cellular Genetic Information: A System Proposal.

One of the great challenges of the scientific community on theories of genetic information, genetic communication and genetic coding is to determine a mathematical structure related to DNA sequences. In this paper we propose a model of an intra-cellular transmission system of genetic information similar to a model of a power and bandwidth efficient digital communication system in order to identify a mathematical structure in DNA sequences where such sequences are biologically relevant. The model of a transmission system of genetic information is concerned with the identification, reproduction and mathematical classification of the nucleotide sequence of single stranded DNA by the genetic encoder. Hence, a genetic encoder is devised where labelings and cyclic codes are established. The establishment of the algebraic structure of the corresponding codes alphabets, mappings, labelings, primitive polynomials (p(x)) and code generator polynomials (g(x)) are quite important in characterizing error-correcting codes subclasses of G-linear codes. These latter codes are useful for the identification, reproduction and mathematical classification of DNA sequences. The characterization of this model may contribute to the development of a methodology that can be applied in mutational analysis and polymorphisms, production of new drugs and genetic improvement, among other things, resulting in the reduction of time and laboratory costs.