The scientific evolution of psychology.

Mode of access: Internet.

Demarcações conceituais dos princípios científicos da Arquivologia e da Ciência da Informação : contribuições para a configuração científica das disciplinas no campo da informação

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciência da Informação, Programa de Pós-Graduação em Ciência da Informação, 2016.

Building the «true evolutionism»: Darwin's impact on Henri Bergson's thought

The paper focuses on the importance of Darwin’s work for the shaping of Henri Bergson’s philosophy, bearing on mind that the two authors first intercepted symbolically in 1859, when On the Origin of Species was published and Bergson was born. Bergson studied the biological sciences of his time, whose results were integrated in a metaphysical thought. He belonged to spiritualistic positivism, a philosophy that goes from the positive data of sciences and finds the ultimate explanation of reality in a spiritual principle. He was interested in the positive evolution of the natural world and in the works of naturalists such as Lamarck, De Vries or Eimer. Darwin was among these authors, being responsible for a vision of evolution that went from the scientific level to other domains. Bergson defends the “insufficiency of pure Darwinism” by pointing out the necessity to compensate scientific evolution with an internal metaphysical reading of the real, which he considered to be “true evolutionism”. This criticism is the most visible aspect of the relations between both works. However, an attentive look verifies that Darwin’s influence overcomes the divergence of positions concerning the extent of “evolution”. The French philosopher knew not only the 1859’s bestseller, but also studies by Darwin about ethology, entomology and botany, which contributed to the fact that the naturalist’s impact gained fundamental importance in Bergson’s philosophical perspective.

On development of fractional calculus during the last fifty years

Fractional calculus generalizes integer order derivatives and integrals. During the last half century a considerable progress took place in this scientific area. This paper addresses the evolution and establishes an assertive measure of the research development.

Patente farmacêutica: especificidades e tutela

Dissertação de mestrado em Direito dos Contratos e da Empresa

Compreendendo a lacuna entre a prática e a evolução técnico-científica do banho no leito

Trata-se de estudo qualitativo, realizado com pacientes acamados, visando compreender a experiência da pessoa dependente da enfermagem para o banho no leito e desenvolver um modelo teórico representativo dessa experiência. Utilizou-se como referencial teórico o Interacionismo Simbólico e, como referencial metodológico, a Grounded Theory. Dos resultados emergiu o fenômeno - aprendendo a avaliar a vida e a enfermagem, ao tornar-se dependente de seus cuidados para o banho no leito. Isso possibilitou identificar a categoria central - propondo um modelo assistencial de enfermagem para o banho no leito, na perspectiva do processo avaliativo do paciente, que contrapõe a evolução técnico-científica relativa ao procedimento.

Existe o quadrinho no vazio entre dois quadrinhos? (ou: o Koan nas histórias em quadrinhos autorais adultas)

Pós-graduação em Artes - IA

Assombros e escombros da modernidade no teatro de Hilda Hilst

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Systemic evaluation - a contribution to Swiss development research

Systemic thinking may be traced hack to several roots. Some of them can he found in Taoism, the basic concepts of which are the achievement of cosmic harmony and a well-balanced social order. Others can be found in Greek philosophy. Similarly, modern physics in its most advanced branches is now recognizing basic aspects of these same roots in a scientific guise. The more the process of research and theory building advances, the more phenomena are recognized as complex and interdependent with other phenomena. Interdisciplinary research and the constitution of new disciplines are contributing to a scientific approximation of integral reality, which is becoming more and more like the one everyone knows as prescientific. The transcendence of the narrow boundaries of positivist sciences seems to be becoming a necessity for scientific evolution. The ecological crisis of the twentieth century may itself lead to increased systemic thinking, and it is in full awareness of the fact that there are no simple solutions that the systemic evaluator tries to cope with the problems of the dynamics of social and political interventions in the Third World as a means of development co-operation..

Evolution of coauthorship networks: worldwide scientific production on leishmaniasis

Introduction Collaboration is one of the defining features of contemporary scientific research, and it is particularly important with regard to neglected diseases that primarily affect developing countries. Methods The present study has identified publications on leishmaniasis in the Medline database from 1945 to 2010, analyzing them according to bibliometric indicators and statistics from social network analysis. Examining aspects such as scientific production, diachronic evolution, and collaboration and configuration of the research groups in the field, we have considered the different types of Leishmania studied and the institutional affiliation and nationality of the authors. Results Seven-hundred and thirty-five authors participate in 154 prominent research clusters or groups. Although the most predominant and consolidated collaborations are characterized by members from the same country studying the same type of Leishmania, there are also notable links between authors from different countries or who study different clinical strains of the disease. Brazil took the lead in this research, with numerous Brazilian researchers heading different clusters in the center of the collaboration network. Investigators from the USA, India, and European countries, such as France, Spain, the United Kingdom, and Italy, also stand out within the network. Conclusions Research should be fostered in countries such as Bangladesh, Nepal, Sudan, and Ethiopia, where there is a high prevalence of different forms of the disease but limited research development with reference authors integrated into the collaboration networks.

On the principle of wealth-creation: its nature, origin, evolution, and corollaries; being a critical reconstruction of scientific political economy.

Mode of access: Internet.

Evaluation of GFP Tag as a Screening Reporter in Directed Evolution of a Hyperthermophilic beta-Glucosidase

By applying a directed evolution methodology specific enzymatic characteristics can be enhanced, but to select mutants of interest from a large mutant bank, this approach requires high throughput screening and facile selection. To facilitate such primary screening of enhanced clones, an expression system was tested that uses a green fluorescent protein (GFP) tag from Aequorea victoria linked to the enzyme of interest. As GFP`s fluorescence is readily measured, and as there is a 1:1 molar correlation between the target protein and GFP, the concept proposed was to determine whether GFP could facilitate primary screening of error-prone PCR (EPP) clones. For this purpose a thermostable beta-glucosidase (BglA) from Fervidobacterium sp. was used as a model enzyme. A vector expressing the chimeric protein BglA-GFP-6XHis was constructed and the fusion protein purified and characterized. When compared to the native proteins, the components of the fusion displayed modified characteristics, such as enhanced GFP thermostability and a higher BglA optimum temperature. Clones carrying mutant BglA proteins obtained by EPP, were screened based on the BglA/GFP activity ratio. Purified tagged enzymes from selected clones resulted in modified substrate specificity.

A Practical Teaching Course in Directed Protein Evolution Using the Green Fluorescent Protein as a Model

Protein engineering is a powerful tool, which correlates protein structure with specific functions, both in applied biotechnology and in basic research. Here, we present a practical teaching course for engineering the green fluorescent protein (GFP) from Aequorea victoria by a random mutagenesis strategy using error-prone polymerase chain reaction. Screening of bacterial colonies transformed with random mutant libraries identified GFP variants with increased fluorescence yields. Mapping the three-dimensional structure of these mutants demonstrated how alterations in structural features such as the environment around the fluorophore and properties of the protein surface can influence functional properties such as the intensity of fluorescence and protein solubility.

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.