Corona ilustre del grauissimo, y real Conuento del Carmen de Valencia enrriquecida de muchas piedras preciosas de hijos suyos ...

Contiene además otros escritos de Fr. Juan Pinto de Victoria, Fr. Ambrosi Roca de la Serna, Fr. Josep Andreu

Clave de los ejercicios contenidos en el método para aprender a leer escribir y hablar el ingles segun el sistema de Ollendorff por Ramón Palenzuela y Juan de la C. Carreño

UANL

Convivimos con el atletismo

Participante en la convocatoria: Premios de buenas pr??cticas en materia de convivencia, Gobierno de Arag??n 2010-11

Procesos cognitivos y estrategias de aprendizaje: fuente y objetivo del diseño curricular de la educación de personas adultas de Castilla y León.

Proyecto realizado por un profesor del Centro Territorial de Educación de Adultos de Tudela de Duero (Valladolid). Tiene como objetivo: profundizar en el conocimiento del proceso y estrategias de aprendizaje desarrolladas por las personas adultas de los Centros de Educación de Personas Adultas de Castilla y León como fuente psicológica del diseño curricular de Educación de Personas Adultas en esta Comunidad Autónoma. El contenido de este estudio se centra en tres grandes bloques: 1) Revisa los diseños curriculares de educación de personas adultas elaborados por las comunidades autónomas con competencias educativas, centrado sobre todo en el papel que en los mismos se asigna a la fuente psicológica. 2) Recoge los conocimientos disponibles sobre el tema fruto de una minuciosa revisión bibliográfica. 3) Analiza el aprendizaje y estrategias utilizadas por un grupo de alumnos de educación de adultos de dos centros de Castilla y León, a partir de las escalas A.C.R.A. (Román y Gallego, 1994). La metodología de trabajo, parte de rastreos bibliográficos en diferentes bases de datos, entrevista a una muestra de alumnos de educación de personas adultas, análisis de resultados, referencias legislativas. El trabajo no ha sido publicado.

Paseo didáctico por la Alameda de Cervantes de Soria.

Se hace una presentación del parque soriano Alameda de Cervantes con el objetivo de dar a conocer las especies vegetales y arbóreas más destacables y frecuentes en los parques urbanos y realizar un aprovechamiento didáctico del mismo. Se proponen una serie de actividades escolares de menor a mayor grado de dificultad y se trata de inculcar a los alumnos el respeto e interés por los árboles y por la observación del medio ambiente, iniciar a los alumnos en el aprendizaje de la botánica y en el desarrollo de actividades científicas y manuales. Se añade un apéndice en el que se recoge material de campo y laboratorio y las claves para identificar frutos y un glosario de botánica para identificar las especies y clases de plantas y conocer su significado.

Ampliación y mejora de aplicativo de análisis forense de imágenes

Ampliación de software dedicado al análisis de imágenes mediante la introducción de nuevas opciones en el procesamiento de video digital, mejoras en la interacción con el usuario. Para ello se ha estudiado el funcionamiento de la aplicación, integrando el lenguaje Python como herramienta de gestión y ejecución de la aplicación. En esta parte de la aplicación se ha integrado: - Traducción de la UI a una versión castellana. - Modificación y eliminación de cualquier filtro añadido para el procesamiento de video, no únicamente el último. - Descripciones de puntero y en la barra de estado de elementos de la aplicación. - Iconos en la barra de herramientas de los filtros añadidos más importantes. Por la otra parte, la del tratamiento digital de video, Avisynth se dispone como el eje de estudio, el cuál ejecuta sobre lenguaje de bajo nivel (C++) las operaciones pertinentes a través de librerías de enlace dinámico o *.dll. Las nuevas funcionalidades son: Convolución matricial, filtro de media adaptativa, DCT, ajustes de video generales, en formato RGB o YUV, rotaciones, cambios de perspectiva y filtrado en frecuencia. ABSTRACT. Improvement about a digital image processing software, creating new options in digital video processing or the user interaction. For this porpuse, we have integrated the application language,Python, as the tool to the application management and execution. In this part of the application has been integrated: - Translation of the UI: Spanish version. - Modifying and removing any added filter for video processing, not just the last. - Descriptions for the pointer and the status bar of the application. - New icons on the toolbar of the most important filters added. On the other hand, Avisynth was used tool for the digital video processing, which runs on low-level language (C ++) for a quickly and to improve the video operations. The new introduced filters are: Matrix Convolution, adaptive median filter, DCT, general video settings on RGB or YUV format, rotations, changes in perspective and frequency filtering.

De la ciudad a la estancia: casas con patio en la vivienda social madrileña (1956-1961). Saénz de Oíza y Vázquez de Castro

La tesis aborda el estudio de la casa patio y su relación con todas las escalas del proyecto, dentro del ámbito de la vivienda colectiva desarrollada en Madrid desde el comienzo de la década de los cincuenta hasta principio de los sesenta. Se investiga su vínculo con la ciudad a partir de la configuración de la trama y los espacios públicos, la organización de la casa en torno a un vacío y las relaciones espaciales entre el patio exterior y las estancias interiores. Mediante el análisis de los diferentes ejemplos existentes de casas con patio en el contexto señalado, se realiza la selección de los casos de estudio de esta investigación. Los proyectos analizados se organizan a partir del trabajo desarrollado por los arquitectos Francisco Javier Sáenz de Oíza y Antonio Vázquez de Castro, liderando equipos más amplios y como representantes de la construcción definitiva de un verdadero lenguaje moderno en la arquitectura española. Cada uno de los proyectos, estructurados en dos apartados para cada uno de los autores, muestran de forma particular, la evolución de las herramientas arquitectónicas empleadas, a partir de la casa patio, en las distintas escalas de trabajo. En los proyectos de Oíza, se analiza en primer lugar la definición de un modelo mínimo y racional de vivienda con patio en el poblado de absorción de Fuencarral “A” (1956) y con el prototipo del concurso de vivienda experimental (1956). A continuación se estudia, en el Poblado Dirigido de Entrevías (1956), la construcción de la ciudad horizontal a partir del patio como elemento estructurante de las tramas urbanas. Las obras de Vázquez de Castro muestran inicialmente la incorporación del patio como una estancia privada más de la casa con la definición de un modelo tipológico en “L” en el Poblado Dirigido de Caño Roto (1956). Finalmente, se analiza el desarrollo de nuevas y complejas estructuras urbanas en forma de tapiz en el proyecto de la Unidad Vecinal de Costa Rica (1961). Los ejemplos, antes descritos, protagonizan un proceso delimitado desde la importación y adaptación de los modelos de vivienda europeos producidos en el periodo de entreguerras, con un significativo retraso; hasta la apuesta por sistemas complejos como el “mat-building”, en diálogo directo, con los proyectos de las nuevas corrientes arquitectónicas internacionales de principios de los sesenta. El estudio y análisis de los ejemplos se realiza mediante la disección pormenorizada de cada uno de ellos, en los sistemas arquitectónicos que establecen la relación del patio con las tres escalas objeto de estudio: la ciudad, la casa y la estancia. Para ello se realiza una reconstrucción de los proyectos mediante la elaboración de una nueva documentación gráfica a partir de los planos y fotografías originales. Finalmente, a partir de los temas arquitectónicos más significativos extraídos del análisis de los casos de estudio y organizados en función de las distintas escalas de proyecto, se realiza una comparación transversal, a modo de conclusiones, respecto a otros ejemplos de similares características del panorama internacional de casas con patio. De esta forma se produce una síntesis sobre los distintos mecanismos que sirvieron para construir, a partir de la tradición del patio en la casa, la vivienda moderna. ABSTRACT The thesis deals the study of the house with courtyard and its relation with all the scales of the project inside the ambience of the collective housing developed in Madrid from the beginning of the fifties up to beginning of the sixties. This document investigates its link with the city from the configuration of the weave and the public spaces, the organization of the house around a void and the spatial relations between the exterior courtyard and the interior spaces. The selection of the case studies of this research is made Through the analysis of the different existing examples of courtyard houses in this defined context. The analyzed projects are organized from the work developed by the architects Francisco Javier Sáenz de Oíza and Antonio Vázquez de Castro, leading wider teams and as representatives of the definitive construction of a real modern language in the Spanish architecture. Each of the projects, structured in two sections to each one of the authors, show in a particular way, the evolution of the architectural tools employed, from the house with courtyard, at different scales of work. In the projects of Oiza, it´s analyced the definition of a minimum and rational model of a house with courtyard in the absorption village of Fuencarral “A” (1956) and with the experimental housing contest prototype (1956). Next, in “el Poblado Dirigido de Entrevías” (1956), the construction of the horinzontal city with the courtyard as a structuring element of the urban weave will be studied. The works of Vázquez de Castro initially show the incorporation of the courtyard as another private area of the house with the typological model definition as an “L” in El Poblado Dirigido de Caño Roto (1956). Finally, the thesis analyzes the development of new and complex urban structures with a mat-building shape in the project of Unidad Vecinal de Costa Rica (1961). The examples described above, starring a process delimited from the import and the adaptation of european housing models produced in the interwar period, with a significant delay; until the opt for complex systems such as the “mat-building”, in direct dialog, with the projects of the new architectural international flows of the beginning of the sixties. The study and analysis of the examples is made by the dissection of them, in the architectural systems that establish the relation of the courtyard with the three scales of the study: the city, the house and the stay. To reach this objetive this document reconstructs the projects making a new graphic documentation from the original maps and photos. Finally, from the most important architectural issues drawn from the analysis of the case studies and organised by the different scales of project, as conclussions, a cross comparison of similar examples of houses with courtyard around the world is made. This produces a synthesis about the different mechanisms that served to build, from the tradition of the courtyard in the house, the modern housing.

Systematic review of Late Jurassic sauropods from the Museu Geológico collections (Lisboa, Portugal)

The Museu Geológico collections house some of the first sauropod references of the Lusitanian Basin Upper Jurassic record, including the Lourinhasaurus alenquerensis and Lusotitan atalaiensis lectotypes, previously considered as new species of the Apatosaurus and Brachiosaurus genera, respectively. Several fragmentary specimens have been classical referred to those taxa, but the most part of these systematic attributions are not supported herein, excluding a caudal vertebra from Maceira (MG 8804) considered as cf. Lusotitan atalaiensis. From the material housed in the Museu Geológico were identified basal eusauropods (indeterminate eusauropods and turiasaurs) and neosauropods (indeterminate neosauropods, diplodods and camarasaurids and basal titanosauriforms). Middle caudal vertebrae with lateral fossae, ventral hollow border by pronounced ventrolateral crests and quadrangular cross-section suggest for the presence of diplodocine diplodocids in north area of the Lusitanian Basin Central Sector during the Late Jurassic. A humerus collected from Praia dos Frades (MG 4976) is attributed to cf. Duriatitan humerocristatus suggesting the presence of shared sauropod forms between the Portugal and United Kingdom during the Late Jurassic. Duriatitan is an indeterminate member of Eusauropoda and the discovery of new material in both territories is necessary to confirm this systematic approach. The studied material is in according with the previous recorded paleobiodiversity for the sauropod clade during the Portuguese Late Jurassic, which includes basal eusauropods (including turiasaurs), diplodocids and macronarians (including camarasaurids and basal titanosauriforms).

Visual outcomes after bilateral trifocal diffractive intraocular lens implantation

Background In recent years new models of intraocular lenses are appearing on the market to reduce requirements for additional optical correction. The purpose of this study is to assess visual outcomes following bilateral cataract surgery and the implant of a FineVision® trifocal intraocular lens (IOL). Methods Prospective, nonrandomized, observational study. Vision was assessed in 44 eyes of 22 patients (mean age 68.4 ± 5.5 years) before and 3 months after surgery. Aberrations were determined using the Topcon KR-1 W wave-front analyzer. LogMAR visual acuity was measured at distance (corrected distance visual acuity, CDVA 4 m), intermediate (distance corrected intermediate visual acuity, DCIVA 60 cm) and near (distance corrected near visual acuity, DCNVA 40 cm). The Pelli-Robson letter chart and the CSV-1000 test were used to estimate contrast sensitivity (CS). Defocus curve testing was performed in photopic and mesopic conditions. Adverse photic phenomena were assessed using the Halo v1.0 program. Results Mean aberration values for a mesopic pupil diameter were: total HOA RMS: 0.41 ± 0.30 μm, coma: 0.32 ± 0.22 μm and spherical aberration: 0.21 ± 0.20 μm. Binocular logMAR measurements were: CDVA −0.05 ± 0.05, DCIVA 0.15 ± 0.10, and DCNVA 0.06 ± 0.10. Mean Pelli-Robson CS was 1.40 ± 0.14 log units. Mean CSV100 CS for the 4 frequencies examined (A: 3 cycles/degree (cpd), B: 6 cpd, C: 12 cpd, D: 18 cpd) were 1.64 ± 0.14, 1.77 ± 0.18, 1.44 ± 0.24 and 0.98 ± 0.24 log units, respectively. Significant differences were observed in defocus curves for photopic and mesopic conditions (p < 0.0001). A mean disturbance index of 0.28 ± 0.22 was obtained. Conclusions Bilateral FineVision IOL implant achieved a full range of adequate vision, satisfactory contrast sensitivity, and a lack of significant adverse photic phenomena. Trial registration Eudract Clinical Trials Registry Number: 2014-003266-2.

Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial

Patients with diabetes mellitus (DM) have high platelet reactivity and are at increased risk of ischaemic events and bleeding post-acute coronary syndromes (ACS). In the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor reduced the primary composite endpoint of cardiovascular death, myocardial infarction, or stroke, but with similar rates of major bleeding compared with clopidogrel. We aimed to investigate the outcome with ticagrelor vs. clopidogrel in patients with DM or poor glycaemic control. We analysed patients with pre-existing DM (n = 4662), including 1036 patients on insulin, those without DM (n = 13 951), and subgroups based on admission levels of haemoglobin A1c (HbA1c; n = 15 150). In patients with DM, the reduction in the primary composite endpoint (HR: 0.88, 95% CI: 0.76-1.03), all-cause mortality (HR: 0.82, 95% CI: 0.66-1.01), and stent thrombosis (HR: 0.65, 95% CI: 0.36-1.17) with no increase in major bleeding (HR: 0.95, 95% CI: 0.81-1.12) with ticagrelor was consistent with the overall cohort and without significant diabetes status-by-treatment interactions. There was no heterogeneity between patients with or without ongoing insulin treatment. Ticagrelor reduced the primary endpoint, all-cause mortality, and stent thrombosis in patients with HbA1c above the median (HR: 0.80, 95% CI: 0.70-0.91; HR: 0.78, 95% CI: 0.65-0.93; and HR: 0.62, 95% CI: 0.39-1.00, respectively) with similar bleeding rates (HR: 0.98, 95% CI: 0.86-1.12). Ticagrelor, when compared with clopidogrel, reduced ischaemic events in ACS patients irrespective of diabetic status and glycaemic control, without an increase in major bleeding events.

Tyrosines in the Carboxyl Terminus Regulate Syk Kinase Activity and Function

The Syk tyrosine kinase family plays an essential role in immunoreceptor tyrosine-based activation motif (ITAM) signaling. The binding of Syk to tyrosine-phosphorylated ITAM subunits of immunoreceptors, such as Fc epsilon RI on mast cells, results in a conformational change, with an increase of enzymatic activity of Syk. This conformational change exposes the COOH-terminal tail of Syk, which has three conserved Tyr residues (Tyr-623, Tyr-624, and Tyr-625 of rat Syk). To understand the role of these residues in signaling, wild-type and mutant Syk with these three Tyr mutated to Phe was expressed in Syk-deficient mast cells. There was decreased Fc epsilon RI-induced degranulation, nuclear factor for T cell activation and NF kappa B activation with the mutated Syk together with reduced phosphorylation of MAP kinases p38 and p42/44 ERK. In non-stimulated cells, the mutated Syk was more tyrosine phosphorylated predominantly as a result of autophosphorylation. In vitro, there was reduced binding of mutated Syk to phosphorylated ITAM due to this increased phosphorylation. This mutated Syk from non-stimulated cells had significantly reduced kinase activity toward an exogenous substrate, whereas its autophosphorylation capacity was not affected. However, the kinase activity and the autophosphorylation capacity of this mutated Syk were dramatically decreased when the protein was dephosphorylated before the in vitro kinase reaction. Furthermore, mutation of these tyrosines in the COOH-terminal region of Syk transforms it to an enzyme, similar to its homolog ZAP-70, which depends on other tyrosine kinases for optimal activation. In testing Syk mutated singly at each one of the tyrosines, Tyr-624 but especially Tyr-625 had the major role in these reactions. Therefore, these results indicate that these tyrosines in the tail region play a critical role in regulating the kinase activity and function of Syk.

Mejora del enfoque comercial en la fase de definición de un proyecto informático

Aquest TFC mira d'analitzar els aspectes comercials que intervenen en les fases inicials de l'execució de projectes informàtics, concretament en la fase d'aprovació i, encara més detingudament, en la fase de definició. Aquestes fases són les mes crítiques per a les entitats dedicades a la gestió de projectes, perquè és on es decideix si són viables.

Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) in second complete remission and six (14%) in third or subsequent response. The cumulative incidence of myeloid engraftment was 96% at a median time of 20 days and significantly better for patients receiving higher doses of CD34(+) cells. The incidence of acute grade II-IV graft-versus-host disease was 31%, while that of overall chronic graft-versus-host disease was 53%. Treatment-related mortality was 17% at day +100 and 31% at 5 years. The 5-year relapse, event-free survival and overall survival rates were 31%, 36% and 44%, respectively. Although the event-free and overall survival rates in patients without BCR/ABL transcripts detectable at time of transplant were better than those in whom BCR/ABL transcripts were detected (46% versus 24% and 60% versus 30%, respectively) these differences were not statistically significant in the univariate analysis (P=0.07). These results demonstrate that umbilical cord blood transplantation from unrelated donors can be a curative treatment for a substantial number of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Wall motion estimation in intracranial aneurysms

The quantification of wall motion in cerebral aneurysms is becoming important owing to its potential connection to rupture, and as a way to incorporate the effects of vascular compliance in computational fluid dynamics (CFD) simulations.Most of papers report values obtained with experimental phantoms, simulated images, or animal models, but the information for real patients is limited. In this paper, we have combined non-rigid registration (IR) with signal processing techniques to measure pulsation in real patients from high frame rate digital subtraction angiography (DSA). We have obtained physiological meaningful waveforms with amplitudes in therange 0mm-0.3mm for a population of 18 patients including ruptured and unruptured aneurysms. Statistically significant differences in pulsation were found according to the rupture status, in agreement with differences in biomechanical properties reported in the literature.

Particle dispersion in synthetic turbulent flows

We study particle dispersion advected by a synthetic turbulent flow from a Lagrangian perspective and focus on the two-particle and cluster dispersion by the flow. It has been recently reported that Richardson¿s law for the two-particle dispersion can stem from different dispersion mechanisms, and can be dominated by either diffusive or ballistic events. The nature of the Richardson dispersion depends on the parameters of our flow and is discussed in terms of the values of a persistence parameter expressing the relative importance of the two above-mentioned mechanisms. We support this analysis by studying the distribution of interparticle distances, the relative velocity correlation functions, as well as the relative trajectories.