Athanasii Kircheri e Soc. Iesu Scrutinium physico-medicum contagiosæ luis, quæ pestis dicitur : quo origo, causæ, signa, prognostica pestis, nec non insolentes malignantis naturæ effectus, qui statis temporibus, cælestium influxuum virtute & efficacia, tum in elementis, tum in epidemijs hominum animantiumque morbis elucescunt, vnà cum appropriatis remediorum antidotis nouâ doctrinâ in lucem eruuntur.

"Errores": p. [15] (3rd group).

Spatial analysis of crime evolution in Portugal between 1995 and 2013

The main objective of this survey was to perform descriptive analysis of crime evolution in Portugal between 1995 and 2013. The main focus of this survey was to analyse spatial crime evolution patterns in Portuguese NUTS III regions. Most important crime types have been included into analysis. The main idea was to uncover relation between local patterns and global crime evolution; to define regions which have contributed to global crime evolution of some specific crime types and to define how they have contributed. There were many statistical reports and scientific papers which have analysed some particular crime types, but one global spatial-temporal analysis has not been found. Principal Component Analysis and multidimensional descriptive data analysis technique STATIS have been the base of the analysis. The results of this survey has shown that strong spatial and temporal crime patterns exist. It was possible to describe global crime evolution patterns and to define crime evolution patterns in NUTS III regions. It was possible to define three to four groups of crimes where each group shows similar spatial crime dynamics.

Assessment of prognosis in patients with stage II colon cancer

Assessment of prognosis of patients with stage II colon cancer.

Familias Estruturadas e Sub-Familias de Matrizes

Desenvolvemos modelos para matrizes estocásticas simétricas com matriz média com característica um. Estas matrizes desempenham um papel relevante em muitas situações interessantes, por exemplo em problemas de componentes principais com primeira componente dominante. Mostramos como ajustar e validar tais modelos e como medir o respectivo grau de Ajustamento através de um estudo de simulações para evidenciar o bom comportamento dos estimadores obtidos. Esse bom comportamento verifica-se quando o primeiro valor próprio da matriz média e suficientemente preponderante. Utilizando a linearidade assimptótica foi possível testar se esta condição se verifica. Al em de modelos para matrizes quase escalares estudamos famílias estruturadas de modelos, cujas matrizes correspondem aos tratamentos de um delineamento base. Consideramos ainda famílias de modelos divididas em subfamílias que correspondem a esses tratamentos. Estamos sobretudo interessados em modelos base com estrutura ortogonal. Apresentamos essa estrutura e mostramos como aplicar esses modelos no estudo de famílias estruturadas. Damos uma aplicação dos nossos resultados a metodologia Statis, concretamente aos resultados de eleições autárquicas em Portugal Continental. Nesta aplicação utilizamos o facto destes modelos serem aplicáveis a primeira e segunda etapas desta metodologia. Assim, consideramos um par de famílias decompostas, em subfamílias que correspondem aos tratamentos do mesmo delineamento base. A primeira família corresponde a primeira etapa da metodologia Statis, e a segunda família corresponde a segunda etapa da mesma metodologia. Estudamos a heterogeneidade das subfamílias de ambas as famílias de modelos. Concluímos que a ordenação das subfamílias a partir da respectiva heterogeneidade se mantém da primeira para a segunda etapa.

Yleisömäärää selittävät muuttujat ja niiden vaikutus seurojen talouteen: Jääkiekon SM-liiga

Tämän tutkimuksen tavoitteena on selvittää jääkiekon SM-liigaotteluiden yleisömäärään vaikuttavia tekijöitä. Jääkiekkoliiketoimintaa harjoittavien yritysten parissa työskentelevillä on vahvat näkemykset urheilumenestyksen vaikutuksesta yleisömäärään, ja sitä kautta seurojen talouteen. Tilastollista tukea näkemyksille ei kuitenkaan ole ollut saatavilla. Aiemmat urheiluliiketoimintaa käsitelleet tutkimukset ovat keskittyneet pääosin taloudelliseen tulokseen, eikä niinkään siihen, miten taloudelliseen tulokseen päädytään. Tutkimus toteutetaan luomalla viisi erilaista yleisömäärää selittävää mallia lineaarista regressioanalyysiä hyödyntäen. Tutkimustulokset osoittavat, että otteluiden yleisömääriä voidaan selittää tilastollisen analyysin avulla. Tulosten perusteella kaikki yleisömäärään liittyvät hypoteesit eivät kuitenkaan ole niin merkitseviä kuin hypoteesien mukaan oletetaan. Tarkastelujakson globaali talouden taantuma loi omat haasteensa urheiluliiketoimintaa harjoittaville yrityksille, mutta taloudellisesti haastava tutkimusajanjakso ei vaikuta olennaisesti tutkimustuloksiin.

Effect of processed and red meat on endogenous nitrosation and DNA damage

Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) meat additionally contains high concentrations of preformed NOC. In two studies, of a fresh RM versus a vegetarian (VEG) diet (six males and six females) and of a nitrite-preserved red meat (PM) versus a VEG diet (5 males and 11 females), we investigated whether processing of meat might increase colorectal cancer risk by stimulating nitrosation and DNA damage. Meat diets contained 420 g (males) or 366 g (females) meat/per day. Faecal homogenates from day 10 onwards were analysed for haem and NOC and asso- ciated supernatants for genotoxicity. Means are adjusted for differ- ences in male to female ratios between studies. Faecal NOC concentrations on VEG diets were low (2.6 and 3.5 mmol/g) but significantly higher on meat diets (PM 175 ± 19 nmol/g versus RM 185 ± 22 nmol/g; P 5 0.75). The RM diet resulted in a larger pro- portion of nitrosyl iron (RM 78% versus PM 54%; P < 0.0001) and less nitrosothiols (RM 12% versus PM 19%; P < 0.01) and other NOC (RM 10% versus PM 27%; P < 0.0001). There was no statis- tically significant difference in DNA breaks induced by faecal water (FW) following PM and RM diets (P 5 0.80). However, PM re- sulted in higher levels of oxidized pyrimidines (P < 0.05). Surpris- ingly, VEG diets resulted in significantly more FW-induced DNA strand breaks than the meat diets (P < 0.05), which needs to be clarified in further studies. Meats cured with nitrite have the same effect as fresh RM on endogenous nitrosation but show increased FW-induced oxidative DNA damage.

Universidade Técnica (UNITEC): instituição educacional de seleção, orientação e formação profissional

O objetivo do presente trabalho tem duplo sentido,em primeiro lugar sugerir um tipo de universidade dirigido ma1S para a pratí ca profissional, selecionando, orientando e formando o estudante atraves de um acompanhamento pela Psicologia Aplicada, assim corno contri - buir com os estudantes de nível médio e superior, através de uma visão do funcionamento do ensino regido por outras universidades de alguns paises do mundo. E bastante exíguo o numero de publicações sobre universidades, principalmente no Brasil, o que coloca os estudiosos do assunto em dificuldades no conhecimento de outros métodos de ensino assim como a sua forma ou técnica de funcionamento. Obras existentes, sobre o assunto, em sua ma10r1a, se limitam a publicações apenas das atividades internas das universidades, ma1S no sentido administrativo e de sua direção, assim como divulga çoes estatísticas de número de formando, sem menC10nar contudo o fluxo grama de sua estrutura psico-pedagógica. O trabalho é rigorosamente fundamentado nas pesqu1sas, ob servações e conclusões advindas de vários anos de experiência no magi~ terio, nao so na area do ensino médio, inclusive industrial, como no ensino superior. Aborda inicialmente uma V1sao concisa da evolução da un1- vers idade, comp lemen tada por uma exp lanação detalhada do ens ino em var1as universidades de outros países, inclusive com seus pré-requisitos. Outra abordagem fundamental, e feita tambem, no sentido ' dos relacionamentos da universidade com o ensino técnico profissional' de nível medio, abordando paralelamente a importância do mercado de trabalho e da Pesquisa Tecnológica. são abordados aspectos da formação de professores e da atualização e especialização para a terceira idade frente a sua experiencia profissional. Finalmente é apresentado um novo tipo de Universidade,que acreditamos ser de alta relevância para o País, tal a gama de areas de ensino que ira atingir, conduzindo os estudantes do maternal ã terceira idade, dentro de uma seleção técnica justa, uma orientação profis - sional autêntica e dentro de seus dotes, assim como uma formação rea lista dentro da ciência, das letras e das artes para cada estudante. Uma comparação do ensino na Universidade Técnica propostacom o enS1no seguido pelas outras universidades, do mundo, facilita uma visão mais clara para que o trabalho nao possa ser considerado como um resumo arbitrário ou "utópico", ou que possa deformar a realidade do ensino complexo, até hoje existente.

Ação antioxidante de alfa-tocoferol e extrato de alecrim em óleo de soja submetido à termoxidação

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Psychometric properties of the Swiss version of the Nursing Home Survey on Patient Safety Culture

The Nursing Home Survey on Patient Safety Culture (NHSPSC) was specifically developed for nursing homes to assess a facility’s safety climate and it consists of 12 dimensions. After its pilot testing, however, no fur- ther psychometric analyses were performed on the instrument. For this study of safety climate in Swiss nursing home units, the NHSPSC was linguistically adapted to the Swiss context and to address the unit as well as facility level, with the aim of testing aspects of the validity and reliability of the Swiss version before its use in Swiss nursing home units. Psychometric analyses were performed on data from 367 nurs- ing personnel from nine nursing homes in the German-speaking part of Switzerland (response rate = 66%), and content validity (CVI) examined. The statistical influence of unit membership on respondents’ answers, and on their agreement concerning their units’ safety climate, was tested using intraclass corre- lation coefficients (ICCs) and the rWG(J) interrater agreement index. A multilevel exploratory factor analysis (MEFA) with oblimin rotation was applied to examine the questionnaire’s dimensionality. Cronbach’s alpha and Raykov’s rho were calculated to assess factor reliability. The relationship of safety climate dimensions with clinical outcomes was explored. Expert feedback confirmed the relevance of the instru- ment’s items (CVI = 0.93). Personnel showed strong agreement in their perceptions in three dimensions of the questionnaire. ICCs supported a multilevel analysis. MEFA produced nine factors at the within-level (in comparison to 12 in the original version) and two factors at the between-level with satisfactory fit statis- tics. Raykov’s Rho for the single level factors ranged between 0.67 and 0.86. Some safety climate dimen- sions show moderate, but non-significant correlations with the use of bedrails, physical restraint use, and fall-related injuries. The Swiss version of the NHSPSC needs further refinement and testing before its use can be recommended in Swiss nursing homes: its dimensionality needs further clarification, particularly to distinguish items addressing the unit-level safety climate from those at the facility level.

Efeito da geometria do implante dentário e do protocolo de fresagem óssea na estabilidade primária e na osseointegração inicial: estudo experimental em cães

CHAPTER 1 - This study histologically evaluated two implant designs: a classic thread design versus another specifically designed for healing chamber formation placed with two drilling protocols. Forty dental implants (4.1 mm diameter) with two different macrogeometries were inserted in the tibia of 10 Beagle dogs, and maximum insertion torque was recorded. Drilling techniques were: until 3.75 mm (regular-group); and until 4.0 mm diameter (overdrillinggroup) for both implant designs. At 2 and 4 weeks, samples were retrieved and processed for histomorphometric analysis. For torque and BIC (bone-to-implant contact) and BAFO (bone area fraction occupied), a general-linear model was employed including instrumentation technique and time in vivo as independent. The insertion torque recorded for each implant design and drilling group significantly decreased as a function of increasing drilling diameter for both implant designs (p<0.001). No significant differences were detected between implant designs for each drilling technique (p>0.18). A significant increase in BIC was observed from 2 to 4 weeks for both implants placed with the overdrilling technique (p<0.03) only, but not for those placed in the 3.75 mm drilling sites (p>0.32). Despite the differences between implant designs and drilling technique an intramembranous-like healing mode with newly formed woven bone prevailed. CHAPTER 2 - The objective of this preliminary histologic study was to determine whether the alteration of drilling protocols (oversized, intermediate, undersized drilling) present different biologic responses at early healing periods of 2 weeks in vivo in a beagle dog model. Ten beagle dogs were acquired and subjected to surgeries in the tibia 2 weeks before euthanasia. During surgery, 3 implants, 4 mm in diameter by 10 mm in length, were placed in bone sites drilled to 3.5 mm, 3.75 mm, and 4.0 mm in final diameter. The insertion and removal torque was recorded for all samples. Statistical significance was set to 95% level of confidence and the number of dogs was considered as the statistical unit for all comparisons. For the torque and BIC and BAFO, a general linear model was employed including instrumentation technique and time in vivo as independent. Overall, the insertion torque increased as a function of drilling diameter from 4.0 mm, to 3.75 mm, to 3.5 mm, with a significant difference in torque levels between all groups (p<0.001). Statistical assessment of BIC and BAFO showed significantly higher values for the 3.75 mm (recommended) drilling group was observed relative to the other two groups (p<0.001). Different drilling dimensions resulted in variations in insertion torque values (primary stability) and different pattern of healing and interfacial remodeling was observed for the different groups. CHAPTER 3 - The present study evaluated the effect of different drilling dimensions (undersized, regular, and oversized) in the insertion and removal torques of dental implants in a beagle dog model. Six beagle dogs were acquired and subjected to bilateral surgeries in the radii 1 and 3 weeks before euthanasia. During surgery, 3 implants, 4 mm in diameter by 10 mm in length, were placed in bone sites drilled to 3.2 mm, 3.5 mm, and 3.8 mm in final diameter. The insertion and removal torque was recorded for all samples. Statistical analysis was performed by paired t tests for repeated measures and by t tests assuming unequal variances (all at the 95% level of significance). Overall, the insertion torque and removal torque levels obtained were inversely proportional to the drilling dimension, with a significant difference detected between the 3.2 mm and 3.5 mm relative to the 3.8 mm groups (P < 0.03). Although insertion torque–removal torque paired observations was statis- tically maintained for the 3.5 mm and 3.8 mm groups, a significant decrease in removal torque values relative to insertion torque levels was observed for the 3.2 mm group. A different pattern of healing and interfacial remodeling was observed for the different groups. Different drilling dimensions resulted in variations in insertion torque values (primary stability) and stability maintenance over the first weeks of bone healing.

Assimetrias no crescimento e no desenvolvimento económico: um diagnóstico tridimensional da região do Algarve

Dissertação de Mestrado, Gestão Empresarial, Faculdade de Economia, Universidade do Algarve, 2015