Indexação de multimédia com base no SOLR

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Informática

Improving search engines with open Web-based SKOS vocabularies

Dissertação para obtenção do Grau de Mestre em Engenharia Informática

Getting Started with Islandora

Workshop at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Advanced Islandora Workshop

Workshop at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Kramerius - Fedora based open source system for a digital library

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Elasticsearch as a new search engine for Invenio and more

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Reusing repository technology for Cultural Heritage and Special Collections

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Regular follow-up after curative resection of nonsmall cell lung cancer: a real benefit for patients?

Even though complete resection is regarded as the only curative treatment for nonsmall cell lung cancer (NSCLC), >50% of resected patients die from a recurrence or a second primary tumour of the lung within 5 yrs. It remains unclear, whether follow-up in these patients is cost-effective and whether it can improve the outcome due to early detection of recurrent tumour. The benefit of regular follow-up in a consecutive series of 563 patients, who had undergone potentially curative resection for NSCLC at the University Hospital, was analysed. The follow-up consisted of clinical visits and chest radiography according to a standard protocol for up to 10 yrs. Survival rates were estimated using the Kaplan-Meier analysis method and the cost-effectiveness of the follow-up programme was assessed. A total of 23 patients (6.4% of the group with lobectomy) underwent further operation with curative intent for a second pulmonary malignancy. The regular follow-up over a 10-yr period provided the chance for a second curative treatment to 3.8% of all patients. The calculated costs per life-yr gained were 90,000 Swiss Francs. The cost-effectiveness of the follow-up protocol was far above those of comparable large-scale surveillance programmes. Based on these data, the intensity and duration of the follow-up was reduced.

Identification and cloning of the gene encoding BmpC: an outer-membrane lipoprotein associated with Brachyspira pilosicoli membrane vesicles

The intestinal spirochaete Brachyspira pilosicoli causes colitis in a wide variety of host species. Little is known about the structure or protein constituents of the B. pilosicoli outer membrane (OM). To identify surface-exposed proteins in this species, membrane vesicles were isolated from B. pilosicoli strain 95-1000 cells by osmotic lysis in dH(2)O followed by isopycnic centrifugation in sucrose density gradients. The membrane vesicles were separated into a high-density fraction (HDMV; p = 1.18 g CM-3) and a low-density fraction (LDMV; rho=1.12 g cm(-3)). Both fractions were free of flagella and soluble protein contamination. LDMV contained predominantly OM markers (lipo-oligosaccharide and a 29 kDa B. pilosicoli OM protein) and was used as a source of antigens to produce mAbs. Five B. pilosicoli-specific mAbs reacting with proteins with molecular masses of 23, 24, 35, 61 and 79 kDa were characterized. The 23 kDa protein was only partially soluble in Triton X-114, whereas the 24 and 35 kDa proteins were enriched in the detergent phase, implying that they were integral membrane proteins or lipoproteins. All three proteins were localized to the B. pilosicoli OM by immunogold labelling using specific mAbs. The gene encoding the abundant, surface-exposed 23 kDa protein was identified by screening a B. pilosicoli 95-1000 genome library with the mAb and was expressed in Escherichia coli. Sequence analysis showed that it encoded a unique lipoprotein, designated BmpC. Recombinant BmpC partitioned predominantly in the OM fraction of E. coli strain SOLR. The mAb to BmpC was used to screen a collection of 13 genetically heterogeneous strains of B. pilosicoli isolated from five different host species. Interestingly, only strain 95-1000 was reactive with the mAb, indicating that either the surface-exposed epitope on BmpC is variable between strains or that the protein is restricted in its distribution within B. pilosicoli.

Actualización del software asociado a un sistema empresarial real en Django

El objetivo del TFG es ejectuar y documentar el proceso de actualizaci on de un sistema software real de car acter empresarial, perteneciente a la empresa dedicada a las transacciones de divisas Foreign Exchange Solutions SL. El sistema est a implementado en Python 2.7 usando el framework de desarrollo r apido de aplicaciones web Django que, comenzando por su versi on 1.3.1, terminar a al nal del proyecto en la versi on 1.4.10, lo que nos llevar a a tener que actualizar todas las librer as relacionadas, adem as de mejorar la calidad del c odigo e incluso cambiar la estructura del proyecto, prestando adem as especial atenci on a la pruebas unitarias y de regresi on para comprobar el correcto funcionamiento del sistema a lo largo del desarrollo. Todo esto con el n de conseguir las nuevas funcionalidades y caracter sticas que una versi on m as nueva nos ofrece, adem as de mejorar la calidad de la aplicaci on -aumentar la reutilizaci on del c odigo y reducir futuros errores gracias a un c odigo m as sencillo y legible-, aumentar el rendimiento, y obtener una buena cobertura de pruebas. Usaremos adem as la metodolog a agil Scrum, el SGBD PostgreSQL, adem as de otras herramientas como Solr, ElasticSearch, Redis, Celery o Mercurial para el control de versiones.