Chromatin: bind at your own RSC.

Recent work has identified a novel RSC-nucleosome complex that both strongly phases flanking nucleosomes and presents regulatory sites for ready access. These results challenge several widely held views.

Consum responsable i RSC. 'Consumo responsable y RSC'.

Monográfico con el título: 'Educació pel desenvolupament sostenible'. Resumen basado en el de la publicación

La responsabilidad social corporativa (RSC) como instrumento estratégico de comunicación para el incremento del valor de marca: el caso de la publicidad televisiva

Aborda a la Responsabilidad Social Corporativa (RSC) como instrumento estratégico de Comunicación en la actual gestión empresarial; en este marco, el objetivo principal apunta a revelar y precisar el mensaje implícito de la RSC en el relato publicitario y el cómo esta herramienta de comunicación se torna un recurso estratégico que contribuye al valor de marca y su incremento a largo plazo. En este sentido, y previa a una introducción, la tesis consta de dos momentos claramente definidos; un marco teórico, comprendido por los dos primeros capítulos, en el cual se definen conceptos y categorías que acompañaran al desarrollo del trabajo de análisis (La RSC, Comunicación Estratégica, la Marca, la Publicidad, Semiótica del relato publicitario, entre los más importantes). Y un segundo momento, constituido por el tercer capítulo, en el que se presenta y examina, de manera general, el escenario de la RSC en la empresa Telefónica, posterior se lleva a cabo el análisis semiótico del spot “Mi papá trabaja en Movistar”, pieza publicitaria emitida en el año 2008. Finalmente, se generan conclusiones y recomendaciones de dicho trabajo.

Elaboración de una cuenta de gastos RSC como herramienta de gestión del cambio: el caso de Red Eléctrica de España

Una necesidad creciente que se detecta hoy en día en las empresas con programas pioneros de Responsabilidad Social Corporativa (RSC) es desarrollar métodos para valorar cuantitativamente los gastos e ingresos que generan estas acciones de RSC. Estos métodos de valoración tienen como objetivo, por un lado, permitir a las empresas conocer cuál es el impacto de su actividad en la sociedad y, por otro lado, identificar sus resultados financiero y no financiero en tres planos: económico, social y ambiental. En este trabajo se propone una metodología para elaborar una cuenta de gastos de RSC como resultado del proyecto de investigación llevado a cabo con el operador del sistema eléctrico español, Red Eléctrica de España

The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes

The SWI/SNF family of chromatin-remodeling complexes facilitates gene expression by helping transcription factors gain access to their targets in chromatin. SWI/SNF and Rsc are distinctive members of this family from yeast. They have similar protein components and catalytic activities but differ in biological function. Rsc is required for cell cycle progression through mitosis, whereas SWI/SNF is not. Human complexes of this family have also been identified, which have often been considered related to yeast SWI/SNF. However, all human subunits identified to date are equally similar to components of both SWI/SNF and Rsc, leaving open the possibility that some or all of the human complexes are rather related to Rsc. Here, we present evidence that the previously identified human SWI/SNF-B complex is indeed of the Rsc type. It contains six components conserved in both Rsc and SWI/SNF. Importantly, it has a unique subunit, BAF180, that harbors a distinctive set of structural motifs characteristic of three components of Rsc. Of the two mammalian ATPases known to be related to those in the yeast complexes, human SWI/SNF-B contains only the homolog that functions like Rsc during cell growth. Immunofluorescence studies with a BAF180 antibody revealed that SWI/SNF-B localizes at the kinetochores of chromosomes during mitosis. Our data suggest that SWI/SNF-B and Rsc represent a novel subfamily of chromatin-remodeling complexes conserved from yeast to human, and could participate in cell division at kinetochores of mitotic chromosomes.

Screening the RSC stage: the 2014 Live from Stratford-upon-Avon cinema broadcasts

During the Royal Shakespeare Company's 2014 summer season, both parts of Henry IV and The Two Gentlemen of Verona were presented as Live from Stratford-upon-Avon broadcasts in cinemas around the world. This article presents a case study of these broadcasts, drawing on the author's observations and insights as their producer as well as interview contributions from those involved in both the stage and screen presentations. Recognising that the hybrid form of “live cinema” performance has developed rapidly over the past five years but is as-yet little-documented, the study develops an analytical approach to its creative processes and to its aesthetics. This discussion is combined with a consideration of the history of earlier screen adaptations of RSC productions at Stratford-upon-Avon. The article details the stages of the production process for the Live from Stratford-upon-Avon broadcasts in 2014 and considers the ways in which the broadcast teams collaborate with the casts and creative teams of the theatre productions. In addition, the article explores processes of adaptation in the journey from stage to screen, the poetics of multi-camera presentation and questions of “live-ness”, the social experience of viewing performance in the cinema, and possible developments for live theatre on screen.

Guía sobre estrategias de Responsabilidad Social Corporativa y Discapacidad (RSC-D) para las Administraciones y resto del Sector Público

El CERMI, tras la publicación de distintos trabajos y una trayectoria ya de unos cuantos años de interés en la RSC participando, entre otras cosas, en el proyecto de la Fundación Bequal, que seguramente es el futuro de la RSC y la discapacidad, para completar esos trabajos se plantea cómo implantar medidas de RSC Discapacidad en las administraciones públicas. Esta es una guía que pretende ayudar a las administraciones públicas a incluir la discapacidad en su gestión. En esta guía se trabaja con seis líneas de actuación, la primera tiene que ver con el buen gobierno, con la adopción de códigos éticos, no solo adoptarlo sino que sea conocido por la gente, comprensible y aplicable y para eso es importante tener un comité de seguimiento, con un canal de denuncias que sea perfectamente confidencial para que la gente no tenga ningún reparo en denunciar. La segunda línea de actuación es la adhesión a iniciativas de RSC, por los beneficios claros que eso aporta. La tercera línea tiene que ver con el acceso al empleo, desde las cuotas de reserva hasta los protocolos de acogida y todo el desarrollo en igualdad de condiciones de una carrera profesional y del trabajo de personas con discapacidad. La cuarta línea es la contratación pública socialmente responsable, que tiene que ver con la inclusión de cláusulas sociales y con el traslado a la cadena de suministros de la responsabilidad social del cumplimiento de la ley. El cumplimiento de la ley por parte de las empresas, para nosotros sería una política social de incalculable valor. La quinta línea, la atención a los ciudadanos y la sexta línea, las memorias e informes de lo que hacen y aquí también propone que en la medida de lo posible adopten el modelo GRI, con el que la Fundación ONCE, en colaboración con el CERMI, ha pactado para incluir indicadores de discapacidad.

Comunicación de RSC: una revisión de las tesis clásicas sobre la coherencia entre la accción de RSC y la actividad organizacional

La literatura sobre comunicación eficaz de la Responsabilidad Social Corporativa (RSC) es compleja y, en ocasiones, contradictoria respecto al papel de la coherencia entre la actividad de la empresa y las acciones de RSC (fit empresarial clásico). Por una parte, subraya la importancia del fit para una comunicación eficaz. Sin embargo, otros investigadores afirman que el fit podría aumentar el escepticismo y resultar perjudicial. Por último, investigaciones recientes señalan otro tipo de fit: el fit personal, donde lo importante es la coincidencia entre la acción de RSC y los intereses del público. Para intentar esclarecer esta complejidad se llevó a cabo un experimento en el que 86 jóvenes fueron asignados aleatoriamente a tres condiciones experimentales: mensaje de RSC con fit clásico; mensaje de RSC con fit personal y mensaje control. A diferencia de lo que se podría esperar a partir de la literatura previa, no se encontraron diferencias significativas entre los que recibieron el mensaje con fit empresarial y aquellos que recibieron el mensaje control. Por el contrario, aquellos individuos asignados a la condición de fit personal evaluaron a la empresa como más sincera y honesta y manifestaron una intención conductual más favorable hacia ella que los sujetos asignados a la condición de control y que los sujetos asignados a la condición de fit empresarial. El artículo discute la necesidad de replantear el rol del fit clásico empresarial en la comunicación de acciones de RSC y resalta la existencia de otros tipos de fit que pueden ser incluso más determinantes.

Bridging the gap : developing an innovative online resource for international graduate students

This paper describes the development of an innovative online website for international graduate students studying at universities in Australia. In 2008, the Queensland University of Technology (QUT) in Australia identified as a key goal the development of its profile as a research intensive university. One of the performance indicators in realising this goal was to increase the proportion of international graduate students from 20% to 50% over a five-year period. To support these students, the University Research Students Centre (RSC) decided to develop an innovative interactive website called the ‘Doorway to Research’ to help prepare students for their arrival in Australia, by providing access to information and support between the period of their acceptance to their graduate programs and their arrival into the country.

High performance additive manufactured scaffolds for bone tissue engineering application

This study demonstrates the feasibility of additive manufactured poly(3-caprolactone)/silanized tricalcium phosphate (PCL/TCP(Si)) scaffolds coated with carbonated hydroxyapatite (CHA)-gelatin composite for bone tissue engineering. In order to reinforce PCL/TCP scaffolds to match the mechanical properties of cancellous bone, TCP has been modified with 3-glycidoxypropyl trimethoxysilane (GPTMS) and incorporated into PCL to synthesize a PCL/TCP(Si) composite. The successful modification is confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) analysis. Additive manufactured PCL/TCP(Si) scaffolds have been fabricated using a screw extrusion system (SES). Compression testing demonstrates that both the compressive modulus and compressive yield strength of the developed PCL/TCP(Si) scaffolds fall within the lower ranges of mechanical properties for cancellous bone, with a compressive modulus and compressive yield strength of 6.0 times and 2.3 times of those of PCL/TCP scaffolds, respectively. To enhance the osteoconductive property of the developed PCL/TCP(Si) scaffolds, a CHA-gelatin composite has been coated onto the scaffolds via a biomimetic co-precipitation process, which is verified by using scanning electron microscopy (SEM) and XPS. Confocal laser microscopy and SEM images reveal a most uniform distribution of porcine bone marrow stromal cells (BMSCs) and cellsheet accumulation on the CHA-gelatin composite coated PCL/TCP(Si) scaffolds. The proliferation rate of BMSCs on the CHA-gelatin composite coated PCL/TCP(Si) scaffolds is 2.0 and 1.4 times higher compared to PCL/TCP(Si) and CHA coated PCL/TCP(Si) scaffolds, respectively, by day 10. Furthermore, the reverse transcription polymerase chain reaction (RT-PCR) and western blot analyses reveal that CHA-gelatin composite coated PCL/TCP(Si) scaffolds stimulate osteogenic differentiation of BMSCs the most compared to the other scaffolds. In vitro results of SEM, confocal microscopy and proliferation rate also show that there is no detrimental effect of GPTMS modification on biocompatibility of the scaffolds.

Design, fabrication and characterization of PCL electrospun scaffolds—a review

The expanding interest in electrospinning fibers for bioengineering includes a significant use of polyesters, including poly(3-caprolactone) (PCL). This review summarizes literature on PCL and selected blends, and provides extensive descriptions of the broad range of parameters used in manufacturing such electrospun fibers. Furthermore the chemical, physical and biological approaches for characterizing the electrospun material are described and opinions offered on important information to include in future publications with this electrospun material.

Doorway to research : Issues in the development of an interactive website for international graduate students

This paper describes results of a study evaluating the content, functionality and design features of an innovative online website called the Doorway to Research (http://rsc.acid.net.au/Main.aspx) , which was developed to support international graduate students studying at universities in Australia. First, the key features of the website are described. Second, the result of a pilot study involving 12 students and faculty members who tested key aspects of the design, content and functionality of the website and provided written and oral feedback base on task-based questions and focus group discussions are explored. Finally, recommendations for future development are presented. Results of the study indicate general student satisfaction with the website and its design, content and functionality, with specific areas identified for further development.

Selective reductions using visible light photocatalysts of supported gold nanoparticles

Photocatalytic synthesis using visible light is a desirable chemical process because of its potential to utilize sunlight. Supported gold nanoparticles (Au-NPs) were found to be efficient photocatalysts and the effects of the supports were identified including CeO2, TiO2, ZrO2, Al2O3, and zeolite Y. In particular Au/CeO2 exhibited the high catalytic activity to reduce nitroaromatics to azo compounds, hydrogenate azobenzene to hydroazobenzene, reduce ketones to alcohols, and deoxygenate epoxides to alkenes at ambient temperatures, under irradiation of visible light (or simulated sunlight). The reac-tive efficiency depends on two primary factors: one is the light adsorption of catalysts and another is the driving ability of catalysts corresponding to the reactants. The light absorption by Au-NPs is due to surface plasmon resonance effect or inter-band electron transition; this is related to the reduction ability of the photocatalysts. Irradiation with shorter wavelengths can excite the conduction electrons in Au-NPs to higher energy levels and as a result, induce reduction with more negative reduction potentials. It is known when irradiated with light the Au-NPs can abstract hydrogen from isopropanol forming Au-H species on the Au-NP surface. Hence, we proposed that the active Au-H species will react with the N=O, N=N, C=O double bonds or epoxide bonds, which are weakened by the interaction with the excited electrons in the Au-NPs, and yield the final reductive products. The reacting power of the Au-H species depends on the energy of the excited electrons in Au-NPs: the higher the electronic energy, the stronger the reduction ability of the Au-H species. This finding demonstrates that we can tune the reduction ability of the photocatalysts by manipulating the irradiation wavelength.

Synthesis, structural analysis, and thermal decomposition studies of [(NH3)2BH2]B3H8

Boron–nitrogen containing compounds with high hydrogen contents as represented by ammonia borane (NH3BH3) have recently attracted intense interest for potential hydrogen storage applications. One such compound is [(NH3)2BH2]B3H8 with a capacity of 18.2 wt% H. Two safe and efficient synthetic routes to [(NH3)2BH2]B3H8 have been developed for the first time since it was discovered 50 years ago. The new synthetic routes avoid a dangerous starting chemical, tetraborane (B4H10), and afford a high yield. Single crystal X-ray diffraction analysis reveals N–Hδ+Hδ−–B dihydrogen interactions in the [(NH3)2BH2]B3H8·18-crown-6 adduct. Extended strong dihydrogen bonds were observed in pure [(NH3)2BH2]B3H8 through crystal structure solution based upon powder X-ray analysis. Pyrolysis of [(NH3)2BH2]B3H8 leads to the formation of hydrogen gas together with appreciable amounts of volatile boranes below 160 °C.

Modelling carbon membranes for gas and isotope separation

Molecular modelling has become a useful and widely applied tool to investigate separation and diffusion behavior of gas molecules through nano-porous low dimensional carbon materials, including quasi-1D carbon nanotubes and 2D graphene-like carbon allotropes. These simulations provide detailed, molecular level information about the carbon framework structure as well as dynamics and mechanistic insights, i.e. size sieving, quantum sieving, and chemical affinity sieving. In this perspective, we revisit recent advances in this field and summarize separation mechanisms for multicomponent systems from kinetic and equilibrium molecular simulations, elucidating also anomalous diffusion effects induced by the confining pore structure and outlining perspectives for future directions in this field.