Production Cycle Optimization: Defining the Market Potential for a New Planning Tool

An optimization tool has been developed to help companies to optimize their production cycles and thus improve their overall supply chain management processes. The application combines the functionality that traditional APS (Advanced Planning System) and ARP (Automatic Replenishment Program) systems provide into one optimization run. A qualitative study was organized to investigate opportunities to expand the product’s market base. Twelve personal interviews were conducted and the results were collected in industry specific production planning analyses. Five process industries were analyzed to identify the product’s suitability to each industry sector and the most important product development areas. Based on the research the paper and the plastic film industries remain the most potential industry sectors at this point. To be successful in other industry sectors some product enhancements would be required, including capabilities to optimize multiple sequential and parallel production cycles, handle sequencing of complex finishing operations and to include master planning capabilities to support overall supply chain optimization. In product sales and marketing processes the key to success is to find and reach the people who are involved directly with the problems that the optimization tool can help to solve.

Projecto de Expansão do ContiSeal

Com o crescente aumento na procura de pneus com maior capacidade de mobilidade, como é caso dos pneus ContiSeal, a Continental AG iniciou um projecto de expansão da unidade industrial portuguesa onde a tecnologia ContiSeal é aplicada, projecto esse a ser desenvolvido pela Continental Mabor. Na prossecução deste projecto são necessárias diversas áreas de conhecimento da gestão industrial, nomeadamente: a análise dos fluxos produtivos, o cálculo de capacidade e respectiva análise de tempos perdidos, análise e projecto de layouts e a produção de propostas de optimização tanto ao nível de equipamentos como do fluxo produtivo. Na realização deste projecto foi necessário estudar profundamente a unidade produtiva em questão. O estudo foi realizado aos diversos subprocessos do ContiSeal, na qual a recolha e análise de dados estão fundamentadas através de extensos levantamentos obtidos por amostragem. Estes dados são vitais para uma correcta análise de custos de investimento na aquisição de novos equipamentos, sendo estes necessários para o cumprimento dos objectivos propostos para a expansão do ContiSeal. O início do projecto incidiu no estudo detalhado sobre os ciclos produtivos dos equipamentos e no levantamento e registo dos tempos perdidos da unidade industrial, que permitiu a análise das capacidades instaladas dos vários subprocessos. Após o levantamento das capacidades foram determinadas as necessidades relativas à aquisição de novos equipamentos. De notar que alguns protótipos de equipamentos necessários foram desenvolvidos em parceria com fornecedores seleccionados, assim como foram apresentadas propostas de melhoria aos equipamentos já existentes. Uma vez aprovada a aquisição dos novos equipamentos pela Continental AG, deu-se início ao desenvolvimento da expansão do layout do ContiSeal, tanto ao nível do edifício como de novos equipamentos e ainda do fluxo dos pneus com vista à sua optimização.

Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate

Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC 48272 (C-10) was cultivated in a synthetic medium containing glucose as major carbon and energy source. The additional medium contained a hydrolyzed sucrose solution as the main carbon and energy source and it was added after the glucose depletion. By manipulating the supplementary feed rate, it was possible to increase antibiotic production. A mathematical model to represent the fed-batch production process was developed. It was observed that the model was applicable under different operation conditions, showing that optimization studies can be made based on this model. (C) 1999 Elsevier B.V. Ltd. All rights reserved.

Syngas production by water electrolysis: preliminary tests on methane production

Master Thesis to obtain the Master degree in Chemical Engineering - Branch Chemical Processes

Aplicação de princípios e ferramentas lean numa unidade de cirurgia de ambulatório de um hospital

Dissertação de mestrado integrado em Engenharia Industrial

Use of interactive performance optimization for identifying the ideal profile of swine finishing producers

The present research aimed to develop a modeling capable of identifying the ideal profile of swine finishing producers using the interactive performance optimization, which began by verifying qualitative the criteria considered most relevant to the decision-making, generating a closed structured diagnosis that covers the socioeconomic aspects about the activity, until the design of a mathematical model able to translate the data obtained in quantitative information. For the verification, it was proposed a practical study for a universe of 120 members of a cooperative in the state of Rio Grande do Sul, Brazil. The results showed that, from the application and the definition of the ideal profile, it was possible to verify that 82 producers are in the group of those who have obtained a "Good" performance, and to 44 the result is in the range between 86% to 90% from the ideal, which means that most have short or medium-term conditions to evolve their status for the considered "Very Good", where only 12.5% of the producers are currently.

Halocin SH10 production by an extreme haloarchaeon Natrinema sp. BTSH10 isolated from salt pans of South India

Halobacteria, members of the domain Archaea that live under extremely halophilic conditions, are often considered as dependable source for deriving novel enzymes, novel genes, bioactive compounds and other industrially important molecules. Protein antibiotics have potential for application as preserving agents in food industry, leather industry and in control of infectious bacteria. Halocins are proteinaceous antibiotics synthesized and released into the environment by extreme halophiles, a universal characteristic of halophilic bacteria. Herein, we report the production of halocin (SH10) by an extremely halophilic archeon Natrinema sp. BTSH10 isolated from salt pan of Kanyakumari, Tamilnadu, India and optimization of medium for enhanced production of halocin. It was found that the optimal conditions for maximal halocin production were 42 C, pH 8.0, and 104 h of incubation at 200 rpm with 2% (V/V) inoculum concentration in Zobell’s medium containing 3 M NaCl, Galactose, beef extract, and calcium chloride as additional supplements. Results indicated scope for fermentation production of halocin for probable applications using halophilic archeon Natrinema sp. BTSH10

Biocompatible polyhydroxybutyrate (PHB) production by marine Vibrio azureus BTKB33 under submerged fermentation

Polyhydroxybutyrate (PHB) is known to have applications as medical implants and drug delivery carriers and is consequently in high demand. In the present study the possibilities of harnessing potential PHB-producing vibrios from marine sediments as a new source of PHB was investigated since marine environments are underexplored. Screening of polyhydroxyalkanoate (PHA)-producing vibrios from marine sediments was performed using a fluorescent plate assay followed by spectrophotometric analysis of liquid cultures. Out of 828 isolates, Vibrio sp. BTKB33 showed maximum PHA production of 0.21 g/L and PHA content of 193.33 mg/g of CDW. The strain was identified as Vibrio azureus based on phenotypic characterization and partial 16S rDNA sequence analysis. The strain also produced several industrial enzymes: amylase, caseinase, lipase, gelatinase, and DNase. The FTIR analysis of extracted PHA and its comparison with standard PHB indicated that the accumulated PHA is PHB. Bioprocess development studies for enhancing PHA production were carried out under submerged fermentation conditions. Optimal submerged fermentation conditions for enhanced intracellular accumulation of PHA production were found to be 35 °C, pH −7, 1.5 % NaCl concentration, agitation at 120 rpm, 12 h of inoculum age, 2.5 % initial inoculum concentration, and 36 h incubation along with supplementation of magnesium sulphate, glucose, and ammonium chloride. The PHA production after optimization was found to be increased to 0.48 g/L and PHA content to426.88 mg/g of CDW, indicating a 2.28-fold increase in production. Results indicated that V. azureus BTKB33 has potential for industrial production of PHB.

Large-scale production of secreted proteins in Pichia pastoris

The production of recombinant therapeutic proteins is an active area of research in drug development. These bio-therapeutic drugs target nearly 150 disease states and promise to bring better treatments to patients. However, if new bio-therapeutics are to be made more accessible and affordable, improvements in production performance and optimization of processes are necessary. A major challenge lies in controlling the effect of process conditions on production of intact functional proteins. To achieve this, improved tools are needed for bio-processing. For example, implementation of process modeling and high-throughput technologies can be used to achieve quality by design, leading to improvements in productivity. Commercially, the most sought after targets are secreted proteins due to the ease of handling in downstream procedures. This chapter outlines different approaches for production and optimization of secreted proteins in the host Pichia pastoris. © 2012 Springer Science+business Media, LLC.

Swarm intelligence for scheduling: a review

Swarm Intelligence generally refers to a problem-solving ability that emerges from the interaction of simple information-processing units. The concept of Swarm suggests multiplicity, distribution, stochasticity, randomness, and messiness. The concept of Intelligence suggests that problem-solving approach is successful considering learning, creativity, cognition capabilities. This paper introduces some of the theoretical foundations, the biological motivation and fundamental aspects of swarm intelligence based optimization techniques such Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO) and Artificial Bees Colony (ABC) algorithms for scheduling optimization.

Gestão de fluxos de produção numa unidade cirúrgica de ambulatório

Dissertação de mestrado em Engenharia Industrial

Press forming of paperboard – advancement of converting tools and process control

Press forming is nowadays one of the most common industrial methods in use for producing deeper trays from paperboard. Demands for material properties like recyclability and sustainability have increased also in the packaging industry, but there are still limitations related to the formability of paperboard. A majority of recent studies have focused on material development, but the potential of the package manufacturing process can also be improved by the development of tooling and process control. In this study, advanced converting tools (die cutting tools and the press forming mould) are created for production scale paperboard tray manufacturing. Also monitoring methods that enable the production of paperboard trays with enhanced quality, and can be utilized in process control are developed. The principles for tray blank preparation, including creasing pattern and die cutting tool design are introduced. The mould heating arrangement and determination of mould clearance are investigated to improve the quality of the press formed trays. The effect of the spring back of the tray walls on the tray dimensions can be managed by adjusting the heat-related process parameters and estimating it at the mould design stage. This enables production speed optimization as the process parameters can be adjusted more freely. Real-time monitoring of pressing force by using multiple force sensors embedded in the mould structure can be utilized in the evaluation of material characteristics on a modified production machinery. Comprehensive process control can be achieved with a combination of measurement of the outer dimensions of the trays and pressing force monitoring. The control method enables detection of defects and tracking changes in the material properties. The optimized converting tools provide a basis for effective operation of the control system.

De anställdas outnyttjade kreativitet : En fallstudie på Ica DE Borlänge

Syftet med examensarbetet var att med utgångspunkt i ett konkret exempel, beskriva hur företag kan organisera verksamheten för att ta till vara på de anställdas outnyttjade kreativitet. Materialet i examensarbetet kan mycket väl tillämpas och användas i andra organisationer än den studerade organisationen Ica DE Borlänge. Dock bör beaktande tas till den specifika kontexten som föreligger vid implementeringen av materialet. Med stöd av den teoretiska referensramen visar resultaten av analysen ett behov av en ny organisationsstruktur med tydliga roller och nya belöningssystem. Den studerade organisationen är en lärande organisation där ett medarbetarengagemang söker främjas. Genom en ny organisationsstruktur med tydliga roller ökar detta medarbetarengagemanget och fler genomförda förbättringar genomförs snabbare, vilket bidrar till att de anställdas outnyttjade kreativitet tillvaratas på ett framgångsrikt sätt. De nya belöningssystemen flyttar fokus till medarbetarengagemanget och förbättringsarbetet, vilket främjar ett genomsyrande Lean-tänkande i organisationen. Belöningssystemen skapar även jämnare produktionsflöden som höjer arbetssäkerheten, ökar produktionskvalitén, minimerar stress samt skapar goda förutsättningar för att beräkna personalbemanningen. Kvalitativa metoder har använts för datainsamlingen. Dessa utfördes genom en förstudie och en fallstudie. Fallstudien bestod utav bakgrundsintervjuer, en intervjustudie samt en observation. Det empiriska materialet visar att organisationen arbetar med ett omfattande förbättringsarbete i alla organisatoriska nivåer. Både chefer och medarbetare har viljan och ambitionen att få till ett framgångsrikt förbättringsarbete, men trots flera års arbete med Lean efterfrågas ändå mer tid, bättre organisationsstruktur samt en sambandskoordinatör med specialistkompetens som driver förbättringsarbetet framåt. Empirin ger en viss indikation på att förbättringsverksamheten har anpassats och organiserats till den befintliga organisationsstrukturen. Förbättringsarbetet torde bli mer framgångsrikt om verksamheten anpassas och organiseras utefter de anställdas outnyttjade kreativitet istället. I summering av slutsatsen åskådliggörs två centrala variabler som kan bidra till långsiktiga framgångar i arbetet med att tillvarata de anställdas outnyttjade kreativitet. En ny organisationsstruktur med tydliga roller som fokuserar på förbättringsarbetet samt nya belöningssystem för inlämnade förbättringsförslag, skulle vara av stor betydelse för ett långsiktigt medarbetarengagemang i en framgångsrik organisation.

Innovation districts: an investigation of the replication of the 22@ Barcelona’s Model in Boston

In 2000, the city of Barcelona launched 22@ Barcelona, dubbed the innovation district. The city sees the project as a means to accelerate Barcelona’s transition toward the knowledge economy. Other cities around the world have since followed the example of Barcelona, building or planning to build their own innovation districts. Boston began to establish its innovation district in 2010. Cities’ ultimate goal for these initiatives is to become more innovative and thus more competitive. Innovative districts are different from technology parks in that they aim to respond to a new economic paradigm in which economic production flows back to cities. The 22@ Barcelona model involves theoretical designs regarding five layers of innovation: economics, urban planning, productive, innovative, and creative. The comparative approach between 22@ Barcelona and Boston’s Innovation District intends to highlight the similarities and differences between those two innovation districts as well as providing a framework to define innovation districts.

Sistemas de automação e supervisão do laboratório de avaliação dos processos de medição de vazão e BSW

During a petroleum well production process, It is common the slmultaneous oil and water production, in proportion that can vary from 0% up to values close to 100% of water. Moreover, the production flows can vary a lot, depending on the charaeteristies of eaeh reservoir. Thus being, the meters used in field for the flow and BSW (water in the oil) measurement must work well in wide bands of operation. For the evaluation of the operation of these meters, in the different operation conditions, a Laboratory will be built in UFRN, that has for objective to evaluate in an automatic way the processes of flow and BSW petroleum measurement, considering different operation conditions. The good acting of these meters is fundamental for the accuracy of the measures of the volumes of production liquid and rude of petroleum. For the measurement of this production, the petroleum companies use meters that should indicate the values with tha largast possible accuracy and to respect a series of conditions and minimum requirements, estabelished by the united Entrance ANP/INMETRO 19106/2000. The laboratory of Evafuation of the Processes of Measurement of Flow and BSW to be built will possess an oil tank basically, a tank of water, besides a mixer, a tank auditor, a tank for separation and a tank of residues for discard of fluids, fundamental for the evaluation of the flow metars and BSW. The whole process will be automated through the use of a Programmable Logicat Controller (CLP) and of a supervisory system.This laboratory besides allowing the evaluation of flow meters and BSW used by petroleum companies, it will make possible the development of researches related to the automation. Besides, it will be a collaborating element to the development of the Computer Engineering and Automation Department, that it will propitiate the evolution of the faculty and discente, qualifying them for a job market in continuous growth. The present work describes the project of automation of the laboratory that will be built at of UFRN. The system will be automated using a Programmable Logical Controller and a supervisory system. The programming of PLC and the screens of the supervisory system were developed in this work