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Simon and Becky Endnote library

This is a general future of tobacco library - it's pretty big and needs a cleanup, all in good time!

Simon and others during Aldermaston Peace march, Ipswich to Brisbane 1964

Simon and others during Aldermaston Peace march, Sunday April 5, 1964. The march covered the distance between Ipswich and Brisbane, Australia, walked in relays covering approximately two miles each. Most relay sections were sponsored by one or more individual organisations.

Simon and other participants during Aldermaston Peace march, Ipswich to Brisbane 1964

Simon and other participants during Aldermaston Peace march, Sunday April 5, 1964. The march covered the distance between Ipswich and Brisbane, Australia, walked in relays covering approximately two miles each. Most relay sections were sponsored by one or more individual organisations.

Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation

We have identified truncating mutations in the human DLG3 ( neuroendocrine dlg) gene in 4 of 329 families with moderate to severe X-linked mental retardation. DLG3 encodes synapse-associated protein 102 (SAP102), a member of the membrane-associated guanylate kinase protein family. Neuronal SAP102 is expressed during early brain development and is localized to the postsynaptic density of excitatory synapses. It is composed of three amino-terminal PDZ domains, an src homology domain, and a carboxyl-terminal guanylate kinase domain. The PDZ domains interact directly with the NR2 subunits of the NMDA glutamate receptor and with other proteins responsible for NMDA receptor localization, immobilization, and signaling. The mutations identified in this study all introduce premature stop codons within or before the third PDZ domain, and it is likely that this impairs the ability of SAP102 to interact with the NMDA receptor and/or other proteins involved in downstream NMDA receptor signaling pathways. NMDA receptors have been implicated in the induction of certain forms of synaptic plasticity, such as long-term potentiation and long-term depression, and these changes in synaptic efficacy have been proposed as neural mechanisms underlying memory and learning. The disruption of NMDA receptor targeting or signaling, as a result of the loss of SAP102, may lead to altered synaptic plasticity and may explain the intellectual impairment observed in individuals with DLG3 mutations.

A Ideia de Tradução da Bíblia no Século XVII: Sacy e Simon

Revista Lusófona de Línguas, Culturas e Tradução

A celebração do casamento do Príncipe Carlos com Camilla Parker Bowles: mediação e mediatização

Tendo presente a relação que o discurso estabelece com a sociedade como um todo, este artigo procura analisar o modo como a monarquia britânica representou o segundo casamento do Príncipe Carlos e o modo como os media construíram os relatos do acontecimento desde 10 de Fevereiro a 9 de Abril de 2005 relativamente a assuntos mais vastos, como sejam as relações de poder, as estruturas económicas dos jornais e a cultura popular. Foi dada particular relevância aos aspectos multifuncionais do discurso (por exemplo, as funções ideacional, interpessoal e textual), o que requer uma leitura contextualizada de um duplo processo de mediação: por um lado, a organização da cerimónia levada a cabo pelo Palácio de St. James e a sua subsequente estratégia para atingir um fechamento monológico e, por outro, as representações discursivas da imprensa britânica, abertas a uma polifonia de vozes e a vários enquadramentos discursivos.

The wedding of Prince Charles and Camilla Parker-Bowles: royal mediation and press mediatization

Bearing in mind the relationship between discourse and society at large, this article addresses the way the British monarchy represented Charles’s second marriage and the way the media constructed their accounts in the period from 10 February (announcement) until 9 April 2005 (wedding) in relation to wider issues such as power relations, newspaper economic structures and popular culture. Particular attention is paid to the multifunctional features of discourse (i.e. its ideational, interpersonal and textual functions), which requires a contextualized reading of a dual process of mediation: on the one hand, the staging of the ceremony by St. James’s Palace and its strategy for attaining monologic closure and, on the other hand, discursive representations by the British press open to a polyphony of voices and discursive frames