Nelles Family collection

The textual materials of the Nelles Family includes account books, clippings, correspondence, diaries, militia records, and various other materials that document the activities of this family. The bulk of the collection consists of photocopies acquired through donation and from other repositories.

Promissory Note, February 2, 1812 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 50 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate, three years after the date. Witness Will Crooks.

Promissory Note, February 2, 1813 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 50 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate, four years after the date. Witness Will Crooks.

Promissory Note, February 2, 1811 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 50 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate. Paid in full. Witness Will Crooks.

Promissory Note, February 2, 1814 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 50 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate, five years after the date. Witness Will Crooks.

Promissory Note, February 2, 1815 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 50 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate, six years after the date. Witness Will Crooks.

Promissory Note, February 2, 1816 - William and Abraham Nelles and Nathanial Pettit Estate

A promise by Abraham and William Nelles to pay 36 pounds with interest, New York Currency, to John Pettit and Jonathan Woolverton, executors of the late Nathanial Pettit estate, seven years after the date. Witness Will Crooks.

Woodruff Family fonds, 1784 – 1983, (non-inclusive)

The Woodruff Family Collection: From the time the Woodruff Family came to Canada from the United States in 1795, they took an active role in the forming of their communities both in a civic and social manner. This is evident through the documents contained in this collection. The Woodruffs played an active role in the battles fought in Upper Canada and they were an integral part of the Village of St. Davids. They were educated, business-minded and socially engaged. They accumulated much of their fortune through land dealings. Much of this collection focuses on Samuel DeVeaux Woodruff who was principally a businessman. His dedication to his work is shown through his numerous undertakings. He made his mark on the Niagara Peninsula through his work on the railways, roads, marsh land revisions, canals and the paper industry. He was also involved with the founding of the Long Point Company and he took control of building DeVeaux Hall down to the last detail. His offspring inherited his work ethic and his business acumen. The people who married into the Woodruff Family also possessed key social, political and business ties. Anne and Margaret Clement were from a staunch Loyalist background. Samuel Zimmerman was instrumental to the founding of Niagara Falls and Judge Samuel DeVeaux left behind a legacy for poor and homeless boys in Niagara Falls, New York. The Woodruff Family undoubtedly left a mark on the Niagara Peninsula. This collection brings to light many endeavours of the family and their varied contributions.

Letter to Robert Nelles of York from his son Henry Nelles of Grimsby

Letter to Robert Nelles of York from his son Henry Nelles of Grimsby (1 double-sided, handwritten page) regarding farming and family matters, Oct. 30, 1818.

Letter to Lieutenant Colonel Robert Nelles of the 4th Lincoln Militia from his daughter Mary Pilkington

Letter to Lieutenant Colonel Robert Nelles of the 4th Lincoln Militia from his daughter Mary Pilkington regarding family matters (1 page, double-sided, handwritten), Feb. 3, 1824.

Letter to Robert Nelles from W. Harris

Letter to Robert Nelles from W. Harris who says that he has just heard of the death of one of his parishioners so he must go to see the family. Most of the letter concerns his carriage. This is accompanied by an envelope postmarked Brockville, Oct. 15, 1851.

The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions

The tissue kallikreins are serine proteases encoded by highly conserved multigene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13 26 genes clustered in one chromosomal locus. It has been recently recognised that the human KLK gene family is of a similar size (15 genes) with the identification of another 12 related genes (KLK4-KLK15) within and adjacent to the original human KLK locus (KLK1-3) on chromosome 19q13.4. The structural organisation and size of these new genes is similar to that of other KLK genes except for additional exons encoding 5 or 3 untranslated regions. Moreover, many of these genes have multiple mRNA transcripts, a trait not observed with rodent genes. Unlike all other kallikreins, the KLK4-KLK15 encoded proteases are less related (25–44%) and do not contain a conventional kallikrein loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression, suggesting evolutionary conservation of elements conferring tissue specificity. These genes are also expressed, to varying degrees, in a wider range of tissues suggesting a functional involvement of these newer human kallikrein proteases in a diverse range of physiological processes.