The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions


Autoria(s): Clements, Judith; Hooper, John D.; Dong, Ying; Harvey, Tracey
Data(s)

2005

Resumo

The tissue kallikreins are serine proteases encoded by highly conserved multigene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13 26 genes clustered in one chromosomal locus. It has been recently recognised that the human KLK gene family is of a similar size (15 genes) with the identification of another 12 related genes (KLK4-KLK15) within and adjacent to the original human KLK locus (KLK1-3) on chromosome 19q13.4. The structural organisation and size of these new genes is similar to that of other KLK genes except for additional exons encoding 5 or 3 untranslated regions. Moreover, many of these genes have multiple mRNA transcripts, a trait not observed with rodent genes. Unlike all other kallikreins, the KLK4-KLK15 encoded proteases are less related (25–44%) and do not contain a conventional kallikrein loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression, suggesting evolutionary conservation of elements conferring tissue specificity. These genes are also expressed, to varying degrees, in a wider range of tissues suggesting a functional involvement of these newer human kallikrein proteases in a diverse range of physiological processes.

Identificador

http://eprints.qut.edu.au/23349/

Publicador

Walter de Gruyter

Relação

DOI:10.1515/BC.2001.002

Clements, Judith, Hooper, John D., Dong, Ying, & Harvey, Tracey (2005) The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions. Biological Chemistry, 382(1), pp. 5-14.

Direitos

Copyright 2005 Walter de Gruyter

The final publication is available at www.degruyter.com

Fonte

Faculty of Science and Technology

Tipo

Journal Article