Ein Stadtschloss für Berlin

Der Palast der Republik war ein ungeliebtes, aber authentisches Denkmal der DDR-Geschichte. Nach der Wettbewerbsentscheidung vom November 2008 ist nun klar, dass an seiner Stelle eine Kopie des Berliner Stadtschlosses entstehen wird. Der hier vorgestellte Entwurf von Stefan Haupt illustriert, dass es möglich gewesen wäre, den authentischen DDR-Bau in seiner Substanz zu erhalten, ohne auf eine städtebaulich sinnvolle Teilrekonstruktion des Stadtschlosses zu verzichten.

Analyse der translatorischen Probleme anhand des Originals „Of Mice and Men“ von John Steinbeck und den deutschen Übersetzungen von Elisabeth Rotten, Georg Hofer und Mirjam Pressler

Die Ziel- und Aufgabenstellung dieser Arbeit ist es, die Originalfassung des Romans „Of Mice and Men“ von John Steinbeck und die deutschen Übersetzungen von Elisabeth Rotten, Georg Hofer und Mirjam Pressler zu analysieren. Anschließend werden die literarischen Übersetzungen im Hinblick auf die damit verbundenen translatorischen Probleme und auf die jeweils gewählte Übersetzungsstrategie miteinander verglichen. Zum Schluss wird beurteilt, welche der verschiedenen Lösungsansätze für den deutschsprachigen Leser am adäquatesten sind.

Mirjam Kinoksen exlibris-kokoelma

Mirjam Kinoksen exlibris-kokoelma sisältää yli 10 000 kotimaista exlibristä, ulkomaisia exlibriksiä sekä suuren määrän aiheeseen liittyvää kirjallisuutta. Oululainen kuvaamataidon lehtori Mirjam Kinos (1915-2002) vaikutti pitkään oululaisessa taide-elämässä, kuten kaupungin kuvataidelautakunnassa vuosina 1959-84. Hän on aktiivisesti tuonut exlibris-aihetta esiin järjestämällä näyttelyitä eri puolilla maata ja opettamalla exlibristen tekemistä kursseilla. Vuonna 1989 Kinos julkaisi ensimmäisen suomenkielisen, eurooppalaisen exlibriksen historiaa esittelevän teoksen Exlibris. Mirjam Kinos on myös itse piirtänyt huomattavan määrän exlibriksiä, kaikkiaan noin 330 kappaletta. Suurin osa niistä syntyi 1980-90-luvuilla sen jälkeen, kun hän siirtyi eläkkeelle Oulun Lyseon kuvaamataidon opettajan työstä.

Schlaflied für Mirjam : (Pan, Band IV, Heft 2)

Richard Beer-Hofmann

Mirjam [Musikdruck] : (aus den Judenliedern)

Carl Grosz

An Mirjam

Robert Jaffé

Mirjam ...

Oskar Neumann

Sadoc en Mirjam : een Joodsch tafereel uit de tijden van Jezus omwandeling op aarde.

Translated from the English.

Forest-related partnerships in Brazilian Amazonia: There is more to sustainable forest management than reduced impact logging

There is more to sustainable forest management than reduced impact logging. Partnerships between multiple actors are needed in order to create the institutional context for good forest governance and sustainable forest management and stimulate the necessary local community involvement. The idea behind this is that the parties would be able to achieve more jointly than on their own by combining assets, knowledge, skills and political power of actors at different levels of scale. This article aims to demonstrate by example the nature and variety of forest-related partnerships in Brazilian Amazonia. Based on the lessons learned from these cases and the authors` experience, the principal characteristics of successful partnerships are described, with a focus on political and socioeconomic aspects. These characteristics include fairly negotiated partnership objectives, the active involvement of the public sector as well as impartial brokers, equitable and cost-effective institutional arrangements, sufficient and equitably shared benefits for all the parties involved, addressing socioeconomic drawbacks, and taking measures to maintain sustainable exploitation levels. The authors argue that, in addition to product-oriented partnerships which focus on sustainable forest management, there is also a need for politically oriented partnerships based on civil society coalitions. The watchdog function of these politically oriented partnerships, their awareness-raising campaigns regarding detrimental policies and practices, and advocacy for good forest governance are essential for the creation of the appropriate legal and political framework for sustainable forest management. (C) 2008 Elsevier B.V. All rights reserved.

Structural characterization and immunogenicity in wildtype and immune tolerant mice of degraded recombinant human interferon alpha2b

Purpose - To study the influence of protein structure on the immunogenicity in wildtype and immune tolerant mice of well-characterized degradation products of recombinant human interferon alpha2b (rhIFNα2b). Methods - RhIFNα2b was degraded by metal catalyzed oxidation (M), crosslinking with glutaraldehyde (G), oxidation with hydrogen peroxide (H) and incubation in a boiling water bath (B). The products were characterized with UV absorption, circular dichroism and fluorescence spectroscopy, gel permeation chromatography, reversed-phase HPLC, SDS-PAGE, Western blotting and mass spectrometry. The immunogenicity of the products was evaluated in wildtype mice and in transgenic mice immune tolerant for hIFNα2. Serum antibodies were detected by ELISA or surface plasmon resonance. Results - M-rhIFNα2b contained covalently aggregated rhIFNα2b with three methionines partly oxidized to methionine sulfoxides. G-rhIFNα2b contained covalent aggregates and did not show changes in secondary structure. H-rhIFNα2b was only chemically changed with four partly oxidized methionines. B-rhIFNα2b was largely unfolded and heavily aggregated. Native (N) rhIFNα2b was immunogenic in the wildtype mice but not in the transgenic mice, showing that the latter were immune tolerant for rhIFNα2b. The antirhIFNα2b antibody levels in the wildtype mice depended on the degradation product: M-rhIFNα2b > H-rhIFNα2b ~ N-rhIFNα2b >> B-rhIFNα2b; G-rhIFNα2b did not induce anti-rhIFNα2b antibodies. In the transgenic mice, only M-rhIFNα2b could break the immune tolerance. Conclusions - RhIFNα2b immunogenicity is related to its structural integrity. Moreover, the immunogenicity of aggregated rhIFNα2b depends on the structure and orientation of the constituent protein molecules and/or on the aggregate size.

Optionen zur Absicherung von Währungsrisiken am Beispiel der Starlight AG : Funktionsweise, aktuelle Entwicklung und Marktangebote

[s.c.]

Untersuchungen zur Aktivität der mitochondrialen Permeabilitätstransitionspore in der Cyclophilin-D-Knock-out-Maus (Ppif-/-)

Magdeburg, Univ., Med. Fak., Diss., 2015

Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations

Validated in vitro methods for skin corrosion and irritation were adopted by the OECD and by the European Union during the last decade. In the EU, Switzerland and countries adopting the EU legislation, these assays may allow the full replacement of animal testing for identifying and classifying compounds as skin corrosives, skin irritants, and non irritants. In order to develop harmonised recommendations on the use of in vitro data for regulatory assessment purposes within the European framework, a workshop was organized by the Swiss Federal Office of Public Health together with ECVAM and the BfR. It comprised stakeholders from various European countries involved in the process from in vitro testing to the regulatory assessment of in vitro data. Discussions addressed the following questions: (1) the information requirements considered useful for regulatory assessment; (2) the applicability of in vitro skin corrosion data to assign the corrosive subcategories as implemented by the EU Classification, Labelling and Packaging Regulation; (3) the applicability of testing strategies for determining skin corrosion and irritation hazards; and (4) the applicability of the adopted in vitro assays to test mixtures, preparations and dilutions. Overall, a number of agreements and recommendations were achieved in order to clarify and facilitate the assessment and use of in vitro data from regulatory accepted methods, and ultimately help regulators and scientists facing with the new in vitro approaches to evaluate skin irritation and corrosion hazards and risks without animal data.

The development of the Quality Indicator for Rehabilitative Care (QuIRC): a measure of best practice for facilities for people with longer term mental health problems

BACKGROUND: Despite the progress over recent decades in developing community mental health services internationally, many people still receive treatment and care in institutional settings. Those most likely to reside longest in these facilities have the most complex mental health problems and are at most risk of potential abuses of care and exploitation. This study aimed to develop an international, standardised toolkit to assess the quality of care in longer term hospital and community based mental health units, including the degree to which human rights, social inclusion and autonomy are promoted. METHOD: The domains of care included in the toolkit were identified from a systematic literature review, international expert Delphi exercise, and review of care standards in ten European countries. The draft toolkit comprised 154 questions for unit managers. Inter-rater reliability was tested in 202 units across ten countries at different stages of deinstitutionalisation and development of community mental health services. Exploratory factor analysis was used to corroborate the allocation of items to domains. Feedback from those using the toolkit was collected about its usefulness and ease of completion. RESULTS: The toolkit had excellent inter-rater reliability and few items with narrow spread of response. Unit managers found the content highly relevant and were able to complete it in around 90 minutes. Minimal refinement was required and the final version comprised 145 questions assessing seven domains of care. CONCLUSIONS: Triangulation of qualitative and quantitative evidence directed the development of a robust and comprehensive international quality assessment toolkit for units in highly variable socioeconomic and political contexts