Mathematical investigation of the interactions between the inflammatory response and mechanical aspects of dermal wound repair

Dermal wound repair involves complex interactions between cells, cytokines and mechanics to close injuries to the skin. In particular, we investigate the contribution of fibroblasts, myofibroblasts, TGFβ, collagen and local tissue mechanics to wound repair in the human dermis. We develop a morphoelastic model where a realistic representation of tissue mechanics is key, and a fibrocontractive model that involves a reasonable approximation to the true kinetics of the important bioactive species. We use each of these descriptions to elucidate the mechanisms that generate pathologies such as hypertrophic scars, contractures and keloids. We find that for hypertrophic scar and contracture development, factors regulating the myofibroblast phenotype are critical, with heightened myofibroblast activation, reduced myofibroblast apoptosis or prolonged inflammation all predicted as mediators for scar hypertrophy and contractures. Prevention of these pathologies is predicted when myofibroblast apoptosis is induced, myofibroblast activation is blocked or TGFβ is neutralised. To investigate keloid invasion, we develop a caricature representation of the fibrocontractive model and find that TGFβ spread is the driving factor behind keloid growth. Blocking activation of TGFβ is found to cause keloid regression. Thus, we recommend myofibroblasts and TGFβ as targets for clinicians when developing intervention strategies for prevention and cure of fibrotic scars.

A new mathematical and philosophical dictionary, comprising an explanation of terms and principles of pure and mixed mathematics, and such branches of natural philosophy as are susceptible of mathematical investigation. With historical sketches of the rise, progress and present state of the several departments of these sciences, and an account of the discoveries and writings of the most celebrated authors, both ancient and modern.

Mode of access: Internet.

Scaffolding students’ thinking in mathematical investigations

This article describes some of the issues that teachers might encounter when scaffolding students’ thinking during mathematical investigations. It describes four episodes where a teacher’s scaffolding failed to support students’ mathematical thinking and explores the reasons why the scaffolding was ineffective. Understanding what is ineffective and why is one way to improve pedagogical practice. As a background to these episodes, we first provide an overview of the mathematical investigation. Our paper concludes with some recommendations for judicious scaffolding during investigations.

Canards in advection-reaction-diffusion systems in one spatial dimension

This thesis contains a mathematical investigation of the existence of travelling wave solutions to singularly perturbed advection-reaction-diffusion models of biological processes. An enhanced mathematical understanding of these solutions and models is gained via the identification of canards (special solutions of fast/slow dynamical systems) and their role in the existence of the most biologically relevant, shock-like solutions. The analysis focuses on two existing models. A new proof of existence of a whole family of travelling waves is provided for a model describing malignant tumour invasion, while new solutions are identified for a model describing wound healing angiogenesis.

A aprendizagem da Matemática no 1º ciclo através de atividades de investigação numa comunidade de aprendizagem

Dissertação apresentada para obtenção do grau de Mestre em Educação Matemática na Educação Pré-Escolar e nos 1º e 2º Ciclos do Ensino Básico na especialidade de Didática da Matemática

Computational Structure of Human Language

The central thesis of this report is that human language is NP-complete. That is, the process of comprehending and producing utterances is bounded above by the class NP, and below by NP-hardness. This constructive complexity thesis has two empirical consequences. The first is to predict that a linguistic theory outside NP is unnaturally powerful. The second is to predict that a linguistic theory easier than NP-hard is descriptively inadequate. To prove the lower bound, I show that the following three subproblems of language comprehension are all NP-hard: decide whether a given sound is possible sound of a given language; disambiguate a sequence of words; and compute the antecedents of pronouns. The proofs are based directly on the empirical facts of the language user's knowledge, under an appropriate idealization. Therefore, they are invariant across linguistic theories. (For this reason, no knowledge of linguistic theory is needed to understand the proofs, only knowledge of English.) To illustrate the usefulness of the upper bound, I show that two widely-accepted analyses of the language user's knowledge (of syntactic ellipsis and phonological dependencies) lead to complexity outside of NP (PSPACE-hard and Undecidable, respectively). Next, guided by the complexity proofs, I construct alternate linguisitic analyses that are strictly superior on descriptive grounds, as well as being less complex computationally (in NP). The report also presents a new framework for linguistic theorizing, that resolves important puzzles in generative linguistics, and guides the mathematical investigation of human language.

Narrativas no ensino de funções por meio de investigações matemáticas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Atividades exploratório-investigativas em sala de aula de cálculo I com uso de tecnologia

This study presents the results from a qualitative resource, based on research-action methodology, which examined the innovate teaching practices implementations in the Calculus I during 2011 year. The analysis of collected data from three used sources – an initial questionnaire, an exploratory-investigative classroom, and an interview with some students at the end of the second semester – reveals that the students had appropriated of the technological recourses, using it as a tool to look for the knowledge. The investigative activities with the use of information technologies made the use of multiple representations in solving mathematical tasks, making the transition of numerical, algebraic and geometrical results possible for the students when they have looking for validation of their hypotheses and conjectures during mathematical problems solving. This works helped in the insertion of new practices in the discipline, and their results validate the proposal presented by the teacher, which is the discipline of Calculus use, whose character is strongly linked to the training content of the student, as a discipline whose can contributed to the pedagogical formation of the graduation student, leading him to know the Mathematical Education possibilities, specially the Mathematical Investigation - Solving Problems, in the outlook of dialogued classes where the teacher assumes the facilitator role and where the students become actives in their pursuit of knowledge

As mudanças procedimentais de alunos do ensino médio durante o trabalho com investigação matemática em sala de aula

The paper that if presents, tells a research carried through next to students of the High School, in which activities of mathematical investigation from questions of some examinations of federal and state public universities had been elaborated; later applied to these students in a state school of the inside of São Paulo and with data obtained from their productions, we search to analyze which procedures had been used for them and which procedural changes had occurred. It is intended with this, to collaborate for the mathematical formation of the students of High School aiming at a more significant learning of the mathematical concepts and the procedures involved when working with this type of activity.

A geometria do compasso (1797) de Mascheroni (1750 – 1800) em atividades com o GeoGebra

The present work aims to show a possible relationship between the use of the History of Mathematics and Information and Communication Technologies (TIC) in teaching Mathematics through activities that use geometric constructions of the “Geometry of the Compass” (1797) by Lorenzo Mascheroni (1750-1800). For this, it was performed a qualitative research characterized by an historical exploration of bibliographical character followed by an empirical intervention based on use of the History of Mathematics combined with TIC through Mathematical Investigation. Thus, studies were performed in papers dealing with the topic, as well as a survey to highlight problems and /or episodes of the history of mathematics that can be solved with the help of TIC, allowing the production of a notebook of activities addressing the resolution of historical problems in a computer environment. In this search, we came across the problems of geometry that are presented by Mascheroni stated previously in the work that we propose solutions and investigations using GeoGebra software. The research resulted in the elaboration of an educational product, a notebook of activities, which was structure to allow during its implementation, students can conduct historical and/or Mathematics research, therefore, we present the procedures for realization of each construction, followed at some moments by original solution of the work. At the same time, we encourage students to investigate/reflect its construction (GeoGebra), in addition to making comparisons with the solution Mascheroni. This notebook was applied to two classes of the course of Didactics of Mathematics I (MAT0367) Course in Mathematics UFRN in 2014. Knowing the existence of some unfavorable arguments regarding the use of history of mathematics, such as loss of time, it was found that this factor can be mitigated with the aid of computational resource, because we can make checks using only the dynamism of and software without repeating the construction. It is noteworthy that the minimized time does not mean loss of reflection or maturation of ideas, when we adopted the process of historical and/or Mathematics Investigation

Advanced mathematical modelling and experimental investigation of new torque arms for shaft-mounted drives

Shaft-mounted gearboxes are widely used in industry. The torque arm that holds the reactive torque on the housing of the gearbox, if properly positioned creates the reactive force that lifts the gearbox and unloads the bearings of the output shaft. The shortcoming of these torque arms is that if the gearbox is reversed the direction of the reactive force on the torque arm changes to opposite and added to the weight of the gearbox overloads the bearings shortening their operating life. In this paper, a new patented design of torque arms that develop a controlled lifting force and counteract the weight of the gearbox regardless of the direction of the output shaft rotation is described. Several mathematical models of the conventional and new torque arms were developed and verified experimentally on a specially built test rig that enables modelling of the radial compliance of the gearbox bearings and elastic elements of the torque arms. Comparison showed a good agreement between theoretical and experimental results.

Investigation of the characteristics of an SF6 rotating arc by a mathematical model

A mathematical model has been developed for predicting the performance of rotating arcs in SF6 gas by considering the energy balance and force balance equations. The finite difference technique has been adopted for the computer simulation of the arc characteristics. This method helps in considering the spatial variation of the transport and radiative properties of the arc. All the three heat loss mechanisms-conduction, convection, and radiation-have been considered. Results obtained over a 10 ms (half cycle of 50 Hz wave) current flow period for 1.4 kA (peak) and 4.2 kA (peak), show that the proposed arc model gives the expected behavior of the arc over the range of currents studied.

A mathematical and experimental investigation of microcycle spectral estimates of semiconductor flicker noise

The experimental portion of this thesis tries to estimate the density of the power spectrum of very low frequency semiconductor noise, from 10^-6.3 cps to 1. cps with a greater accuracy than that achieved in previous similar attempts: it is concluded that the spectrum is 1/f^α with α approximately 1.3 over most of the frequency range, but appearing to have a value of about 1 in the lowest decade. The noise sources are, among others, the first stage circuits of a grounded input silicon epitaxial operational amplifier. This thesis also investigates a peculiar form of stationarity which seems to distinguish flicker noise from other semiconductor noise.

In order to decrease by an order of magnitude the pernicious effects of temperature drifts, semiconductor "aging", and possible mechanical failures associated with prolonged periods of data taking, 10 independent noise sources were time-multiplexed and their spectral estimates were subsequently averaged. If the sources have similar spectra, it is demonstrated that this reduces the necessary data-taking time by a factor of 10 for a given accuracy.

In view of the measured high temperature sensitivity of the noise sources, it was necessary to combine the passive attenuation of a special-material container with active control. The noise sources were placed in a copper-epoxy container of high heat capacity and medium heat conductivity, and that container was immersed in a temperature controlled circulating ethylene-glycol bath.

Other spectra of interest, estimated from data taken concurrently with the semiconductor noise data were the spectra of the bath's controlled temperature, the semiconductor surface temperature, and the power supply voltage amplitude fluctuations. A brief description of the equipment constructed to obtain the aforementioned data is included.

The analytical portion of this work is concerned with the following questions: what is the best final spectral density estimate given 10 statistically independent ones of varying quality and magnitude? How can the Blackman and Tukey algorithm which is used for spectral estimation in this work be improved upon? How can non-equidistant sampling reduce data processing cost? Should one try to remove common trands shared by supposedly statistically independent noise sources and, if so, what are the mathematical difficulties involved? What is a physically plausible mathematical model that can account for flicker noise and what are the mathematical implications on its statistical properties? Finally, the variance of the spectral estimate obtained through the Blackman/Tukey algorithm is analyzed in greater detail; the variance is shown to diverge for α ≥ 1 in an assumed power spectrum of k/|f|^α, unless the assumed spectrum is "truncated".