In memory of Rev. and Mrs. John Martin.

Dedication signed J.M.W.

Martin Riesenburger portrait portraits men

Martin Riesenburger (May 14, 1896 – Apr. 14, 1966) was Prediger (Preacher) for the Jewish community in Berlin-Weissensee throughout the Nazi era (protected by his gentile wife, Natalie Riesenburger). In 1953 he became Rabbi of the Jewish community in Berlin (East) and then Landesrabbiner of the German Democratic Republic.

The town and city of Waterbury, Connecticut,

"Family records": v. 1, appendix, p. [1ap]-166ap.

School of Nursing Class of 2004

Top Row: Emma Abramson, Emilee Amo, Philip Arnold, Janet Biezlein, Anna Brede, Lindsey Brighton, Bethany Brown, Connie Brown-Olds, Charlene Bugais, Jammy Coates, Heather Coopex, Angie Costtakes, Jeffin Dejanovich, Jessica Farhat, Renee Filo, Kelly Fons, Katie Francis, Courtney Franklin, Rebecca Fransted

Row 2: Janelle Gailliard, Ericka Gess, Rebecca Goldstein, Candace Graham, Monique Grinnell, Jacob Grossman

Row 3: Joann Haderer, Diane Hamilton, Janet Hasse, Lisa Hoag, Nicole Hoeft, Emily Keeton

Row 4: Annette Keevex, Karen Kevelighan, Kelli Kincaid, Jennifer Kittell, Alison Knapp, Kelly Kulczyk

Row 5: Meejin Kwon, Megan Layher, Autumn Ledtke, Lora Lemaire-Valdez, Jessica Lewis, Diana Loud

Row 6: Melissa Maci, Andrea Magnus, Bre'Anne Mallon, Ada Sue Hinshaw, Patricia Coleman-Burns, Carol Loveland-Cherry, Judith Lynch-Sauer, Judy Wismont, Carrie Marshall, Neika Martin, Sarah Martin

Row 7: Lindsay Mason, Maryanne Matkovich, Alison McCann, Lina srgedas, Paula Graff, Rachel Mundinger, Christopher Ramos, Lauren Bealafeld, Gennifer Gasek, Angie Henderson, Sarah Ansett, Marisa Lirot, Caitlin McClellan, Diane Mille, Theresa Molyneux

Row 8: Isabel Moreno, Kristy Morrison, Phyllis Mulchay, Joielinn Nelson, Ann Newhof, Dawn O'Neil, Shontaya Overall, Theresa Overwater, Katherine Piper, Teresa Pizana, Erica Powers, Sarah Ricci, Leah Richardson, Anne Rucinski, Karon Sanderson, Rachel Sawman, Kathryn Sisterman, Sarah Smart, Curt Smith

Row 9: Elizabeth Stackable, Tracey Streiff, Angelica Susi, Tracy Swerrod, Leah Tatasciore, Julie Thomas, Rebecca Tidrick, Rebecca Vander Werff, Danielle Victor, Andrea Vincent, Katie Wagner, Essence Walker, Myre Ware, Jill Weirich, Kelly Wickham, Karen Wiklanski

The mesenchymal-to-epithelial reverting transition is enriched in metastatic castration resistant prostate cancer and correlates with poor survival

Despite recent recognition that the epithelial-mesenchymal transition (EMT) program acts in a dynamic manner (termed Epithelial to Mesenchymal Plasticity or EMP) during carcinoma metastasis, it has largely been ignored in the discovery and development of EMT-targeted therapies. In part, this has stemmed from a lack of preclinical models that can mimic the full dynamic nature of EMP and the perception that the EMT-reverting transition [or mesenchymal-epithelial reverting transition; (MErT)] is a mere antithesis of EMT. The objective of this study was to develop the first PCa model capable of recapitulating the dynamic nature of EMP.

Literature review and analysis of itinerant teachers of the hearing impaired located in the midwest: Service delivery model in education

The role and responsibilities of an itinerant teacher of students who are deaf or hard of hearing were investigated to create a database of information about the effective traits of successful itinerant teachers.

An examination of cued speech as a tool for language, literacy, and bilingualism for children who are deaf or hard of hearing

This study examines the purpose and uses of Cued Speech, its benefits and limitations, and its effectiveness as a tool for language, literacy, and bilingualism.

Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93

To compare the efficacy of chemoendocrine treatment with that of endocrine treatment (ET) alone for postmenopausal women with highly endocrine responsive breast cancer. In the International Breast Cancer Study Group (IBCSG) Trials VII and 12-93, postmenopausal women with node-positive, estrogen receptor (ER)-positive or ER-negative, operable breast cancer were randomized to receive either chemotherapy or endocrine therapy or combined chemoendocrine treatment. Results were analyzed overall in the cohort of 893 patients with endocrine-responsive disease, and according to prospectively defined categories of ER, age and nodal status. STEPP analyses assessed chemotherapy effect. The median follow-up was 13 years. Adding chemotherapy reduced the relative risk of a disease-free survival event by 19% (P = 0.02) compared with ET alone. STEPP analyses showed little effect of chemotherapy for tumors with high levels of ER expression (P = 0.07), or for the cohort with one positive node (P = 0.03). Chemotherapy significantly improves disease-free survival for postmenopausal women with endocrine-responsive breast cancer, but the magnitude of the effect is substantially attenuated if ER levels are high.

Lehrbuch der hebräisch-jüdischen Archäologie : nebst einem Grundrisse der hebräisch-jüdischen Geschichte

von Wilhelm Martin Leberecht de Wette

RNA-Guided Genome Editing

Ciliates have evolved highly complex and intricately controlled pathways to ensure the precise and complete removal of all genomic sequences not required for vegetative growth. At the same time, they retain a reference copy of all their genetic information for future generations. This chapter describes how different ciliates use RNA-mediated DNA comparison processes to form new somatic nuclei from germline nuclei. While these processes vary in their precise mechanisms, they all use RNA to target genomic DNA sequences—either for retention or elimination. They also all consist of more than one individual pathway acting cooperatively—the two subsets of small RNAs in Paramecium and the guide RNAs and Piwi-interacting RNAs in Oxytricha—to ensure a strong belt-and-braces approach to consistent and precise somatic nucleus development. Nonetheless, this genome comparison approach to somatic nucleus development provides an elegant method for trans-generational environmental adaptation. Conceptually, it is easy to imagine how somatic changes that occur during vegetative growth could be transferred to meiotic offspring, while an unaltered germline genome is retained. Further research in this area will have far-reaching implications for the trans-generational adaptation of more distantly related eukaryotes, such as humans.

POU domain transcription factor Brn3b is critical for the normal development and survival of retinal ganglion cells

The POU domain transcription factor Brn3b/POU4F2 plays a critical role regulating gene expression in mouse retinal ganglion cells (RGCs). Previous investigations have shown that Brn3b is not required for initial cell fate specification or migration; however, it is essential for normal RGC differentiation. In contrast to wild type axons, the mutant neurites were phenotypically different: shorter, rougher, disorganized, and poorly fasciculated. Wild type axons stained intensely with axon specific marker tau-1, while mutant projections were weakly stained and the mutant projections showed strong labeling with dendrite specific marker MAP2. Brn-3b mutant axonal projections contained more microtubules and fewer neurofilaments, a dendritic characteristic, than the wild type. The mutant neurites also exhibited significantly weaker staining of neurofilament low-molecular-weight (NF-L) in the axon when compared to the wild type, and NF-L accumulation in the neuron cell body. The absence of Brn-3b results in an inability to form normal axons and enhanced apoptosis in RGCs, suggesting that Brn-3b may control a set of genes involved in axon formation. ^ Brn3b contains several distinct sequence motifs: a glycine/serine rich region, two histidine rich regions, and a fifteen amino acid conserved sequence shared by all Brn3 family members in the N-terminus and a POU specific and POU homeodomain in the C-terminus. Brn3b activates a Luciferase reporter over 25 fold in cell culture when binding to native brn3 binding sites upstream of a minimal promoter. When fused to the Gal4 DNA Binding domain (DBD) and driven by either a strong (CMV) or weaker (pAHD) promoter, the N-terminal of Brn3b is capable of similar activation when binding to Gal4 UAS sites, indicating a presumptive activator of transcription. Both full length Brn3b or the C-terminus fused to the Gal4DBD and driven by pCMV repressed a Luciferase reporter downstream of UAS binding sites. Lower levels of expression of the fusion protein driven by pADH resulted in an alleviation of repression. This repression appears to be a limitation of this system of transcriptional analysis and a potential pitfall in conventional pCMV based transfection assays. ^

Houston police officer attitudes towards the mentally ill: CIT trained and non-CIT trained

The purpose of this study was to develop a better understanding of police officer attitudes towards the mentally ill and what impact that might have on their behavior. Focused on the effects of Crisis Intervention Team (CIT) training on Houston police officers, this research wanted to determine if CIT training decreases attitudes of authoritarianism and increases attitudes of self-efficacy in dealing with the mentally ill—other factors assessed were age, years of service, ethnicity, and gender. Results confirmed that CIT training had an effect on an officer's attitudes with CIT officers being less authoritarian and having more self-efficacy with respect to dealing with the mentally ill as compared to non-CIT officers. Because of these results, this study could offer support in tailoring training programs to have successful officer-mentally ill person interactions. ^

Architecture,

Bibliographical footnotes.