Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex

Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered GMP on brain cortical glutamatergic parameters in mice. Additionally, we investigated the neuroprotective potential of the GMP treatment submitting cortical brain slices to oxygen and glucose deprivation (OGD). Moreover, measurements of the cerebrospinal fluid (CSF) purine levels were performed after the treatment. Mice received an oral administration of saline or GMP during 3 weeks. GMP significantly decreases the cortical brain glutamate binding and uptake. Accordingly, GMP reduced the immunocontent of the glutamate receptors subunits, NR2A/B and GluR1 (NMDA and AMPA receptors, respectively) and glutamate transporters EAAC1 and GLT1. GMP treatment significantly reduced the immunocontent of PSD-95 while did not affect the content of Snap 25, GLAST and GFAP. Moreover, GMP treatment increased the resistance of neocortex to OGD insult. The chronic GMP administration increased the CSF levels of GMP and its metabolites. Altogether, these findings suggest a potential modulatory role of GMP on neocortex glutamatergic system by promoting functional and plastic changes associated to more resistance of mice neocortex against an in vitro excitotoxicity event.

Iniciación a la enseñanza de la imagen : Comunicación 86.

Alcanzar mayores cotas de interdisciplinariedad en las materias de Lengua Castellana, Inglés, Sociales y Expresión Plástica, utilizando como medio, la iniciación al estudio de la imagen a través de técnicas como el cómic, la fotonovela, la publicidad, el cineforum y el vídeo, con la intención de fomentar la creatividad y la capacidad crítica.

Crescimento da grama bermudas sob diferentes lâminas de irrigação

The objective of the present study was to analyze the most appropriate water depth for maintaining a good quality of Bermudas Grass (Cynodon dactylon) for soccer fields while saving water and electrical resources. Four treatments were used: T1 - irrigated with a water depth of 50% of evapotranspiration (ETo), T2 - irrigated with a water depth of 75% of ETo, T3 - irrigated with a water depth of 100% of ETo and T4 - irrigated with a water depth of 150% of ETo, all treatments were irrigated daily. The reference ETo was obtained by the Penman-Monteith method. The study was conducted in an experimental area of the Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro - Campus Uberaba, Uberaba, Minas Gerais, Brazil, from June to September 2010 and from January to March 2011. Three evaluations of the variables were performed during the experimental period. The samples were obtained with the help of a cylindrical extractor with 10 cm in diameter and 30 cm in height. In each sample height and dry organic matter (leaf, root and organic material) were analyzed. The experimental design was randomized block with four treatments in five blocks. No significant differences were observed for dry matter and height (roots and organic material). The best results were those for T4 which obtained the greatest height.

Laurindo Almeida: dos trilhos de Miracatu às trilhas em Hollywood

Pós-graduação em Música - IA

Laurindo Almeida: dos trilhos de Miracatu às trilhas em Hollywood

Pós-graduação em Música - IA

Os rumos do desenvolvimento nos anos 50: as visões da Cepal e de Roberto Campos Araraquara – SP 2012

In the decade of 1950, the economic policies almost in their entirety, are aimed at promoting domestic industry, culminating finally in the most consistent action planned in favor of industrialization in the economic history of Brazil: the Plano de Metas (Goal’s Plan). This study aims to analyze the Brazilian planning at this moment studying the proposals in the economic thought of the Economic Commission for Latin America and the Caribbean (ECLAC) and Roberto de Oliveira Campos, divergent, but both connected to important reports of the Brazilian economy developed in the period, which served as the basis for policies at the period and even Goal’s Plan, and with enormous influence on the decisions of the 50s. The first one was the most important school of thought in the Third World. Campos was one of the most important thinkers of the economy in the period, one of the most consistent critics of ECLAC, and their proposals were very close to what was actually executed. The paper concludes that, despite the importance of ECLAC thought, this encountered difficulties applying workable solutions to economic growth. The eclectic tone of Roberto Campos brought clarity to his proposals, and these, when applied, have led to growth

Entre o declínio e a reinvenção: atualidade das funções do sistema público atacadista de alimentos no Brasil

Este artigo apresenta evidências das mudanças que estão se processando no aparato atacadista público de alimentos no Brasil abordando a evolução, as características atuais e as funções da estrutura atacadista do sistema brasileiro de abastecimento. O texto aborda algumas considerações sobre o contexto histórico vivido no momento de criação do Sistema Nacional de Abastecimento (Sinac) nos anos 70 e a emergência de novos modelos para os mercados atacadistas a partir dos anos 80. É realizada uma análise com base na observação dos dados coletados junto a 29 centrais de abastecimento públicas brasileiras em 2009 com informações sobre origem e destino dos hortigranjeiros comercializados nesses entrepostos a partir de uma amostra significativa. Os padrões sistêmicos podem ser observados através de dois aspectos: o desempenho da atividade econômica dos principais entrepostos atacadistas brasileiros e as funções remanescentes de reunião e distribuição da produção local e regional. Pretendemos demonstrar que o grupo de centrais públicas de abastecimento é bastante heterogêneo e que, de maneira geral, a dinâmica do seu crescimento é estabelecida de fora para dentro , sendo que muitos destes equipamentos não mais exercem papéis centrais como executores de políticas públicas voltadas para o abastecimento.

Pensamiento del profesorado y alumnado sobre la integración de las TIC y su uso en los centros de adultos de Canarias

Programa de doctorado: Formación del profesorado