Brief narrative of events touching various reforms /

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Effect of cytochalasin B on 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose handling by BRIN-BD11 cells.

The present study aimed to investigate the effects of cytochalasin B (20 μM) on the uptake of 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose (8.3 mM each) by BRIN-BD11 cells. Taking into account the distribution space of tritiated water ((3)HOH), which was unexpectedly increased shortly after exposure of the cells to cytochalasin B and then progressively returned to its control values, and that of L-[1-(14)C]glucose, used as an extracellular marker, it was demonstrated that cytochalasin B caused a modest, but significant inhibition of the uptake of D-glucose and its non-metabolized analog by the BRIN-BD11 cells. These findings resemble those observed in acinar or ductal cells of the rat submaxillary gland and displayed a relative magnitude comparable to that found for the inhibition of D-glucose metabolism by cytochalasin B in purified pancreatic islet B cells. These findings reinforce the view that the primary site of action of cytochalasin B is located at the level of the plasma membrane.

Erinnerungen von einer Reise in den Jahren 1803, 1804 und 1805

von Johanna Schopenhauer

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

N-Methyl-D-aspartate (NMDA) receptor-mediated neurotoxicity may depend, in part, on the generation of nitric oxide (NO.) and superoxide anion (O2.-), which react to form peroxynitrite (OONO-). This form of neurotoxicity is thought to contribute to a final common pathway of injury in a wide variety of acute and chronic neurologic disorders, including focal ischemia, trauma, epilepsy, Huntington disease, Alzheimer disease, amyotrophic lateral scelerosis, AIDS dementia, and other neurodegenerative diseases. Here, we report that exposure of cortical neurons to relatively short durations or low concentrations of NMDA, S-nitrosocysteine, or 3-morpholinosydnonimine, which generate low levels of peroxynitrite, induces a delayed form of neurotoxicity predominated by apoptotic features. Pretreatment with superoxide dismutase and catalase to scavenge O2.- partially prevents the apoptotic process triggered by S-nitrosocysteine or 3-morpholinosydnonimine. In contrast, intense exposure to high concentrations of NMDA or peroxynitrite induces necrotic cell damage characterized by acute swelling and lysis, which cannot be ameliorated by superoxide dismutase and catalase. Thus, depending on the intensity of the initial insult, NMDA or nitric oxide/superoxide can result in either apoptotic or necrotic neuronal cell damage.

D. Bank note, 1805

One bank note for the Bank of England, dated March 29, 1805.

The life and adventures of Guzman d'Alfarache; or, The Spanish rogue.

Mode of access: Internet.

Voyage dans les Iles Baléares et Pithiuses, fait dans les annés 1801,1802,1803,1804 et 1805 /

Mode of access: Internet.

D'Horsay; or, The follies of the day.

Original illustrated cover: "No. IV. April." bound in.

Anteckningar hörande till Kongl.vetensk. akademiens historia,framladge i ett tal vid praesidii nedläggande d.13 februari 1805.

Mode of access: Internet.

The Spanish Armada, A. D. 1588 : or The attempt of Philip II and Pope Sixtus V to re-establish popery in England /

Mode of access: Internet.

Prodromus florae norfolkicae sive Catalogus stirpium quae in insula Norfolk annis 1804 et 1805 a Ferdinando Bauer collectae et depictae nune in Museo caesareo palatino rerum naturalium Vindobonae servantur /

Mode of access: Internet.

The Iris : an illuminated souvenir for MDCCCLII /

Plates lithographed by Peter S. Duval after drawings by Capt. Seth Eastman.

Derekh ha-hashgaḥah : nitḥallek le-arba' netivot /

Tipped in t.p. in transliterated Hebrew ; original t.p. wanting.

Sefer ha-Zohar ha-kadosh: ʻal ha-Torah/

Title within ornamental border containing comments.