Tentativa de balanço: entrevista com Iumna Maria Simon

Narrando a sua formação intelectual, Iumna Maria Simon analisa a situação da crítica literária na universidade e fora dela, a poesia contemporânea e as condições da leitura da obra literária hoje. A entrevista expõe o modo como desenvolveu sua compreensão da literatura brasileira mais recente e como organiza seu foco crítico e suas referências teóricas, enquanto professora e crítica.

Josep Maria Ruiz Simon, A arte de Raimundo Lúlio e a teoria escolástica da ciência, trad. Fernando Salles, Instituto Brasileiro de Filosofía e Ciência “Raimundo Lúlio" (Ramon Llull), Sâo Paulo, 2004. ISBN: 85 - 89294 - 05 - 6. 368 p.

Fil: Mendoza, José María Felipe.

Vida del venerable siervo de Dios, y finissimo capellan de Maria Santissima Padre maestro Fray Simon de Roxas ... /

Mode of access: Internet.

La Route des Flandres de Claude Simon.

Estudio sobre la obra de Claude Simon, titulada La Route des Flandres. Es una de las novelas más destacadas dentro de las que han sido calificadas como Nuoveau Roman. Su protagonista, Georges, narra su historia tal como ésta va surgiendo de su memoria, es decir, por retazas incompletos, llenos de vacíos. La obra es, pues, el reflejo de una memoria espontánea, no siempre fiel a la realidad. La dificultad de transcribir el carácter simultáneo de todos los elementos que componen una visión global de la memoria, la ha superado el autor mediante la dislocación total del relato. Se analiza en profundidad la historia, la estructura narrativa, el montaje y el discurso de la novela. Para concluir se hace referencia a su significado como obra literaria.

Acuerdos de Iunlas [sic] Generales de Merindades de este M.N. y M.L. Señorio de Vizcaya, celebrados en Santa Maria de Begoña, y en ... Bilbao, los dias dos, tres, ... y ocho inclusiue del mes de mayo de este año de mil setecientos nouenta, y tres.

Sign.: []2, A-R2

Constituciones de la Real Cofradia de la SS. Virgen Maria de la Seo, comunmente nombrada del Milagro, Hospital de pobres sacerdotes enfermos de ... 1757

Hay un ejemplar encuadernado con: Satisfacion a vn papel que se dize, seria escrito por el Arçobispo de Valencia a ... Paulo V sobre la veneracion priuada del padre Mossen Francisco Geronimo Simon, presbitero valenciano, beneficiado que fue en la Iglesia Parrochial del Apostol S. Andres ... (XVIII/1557).

Simon Boccanegra. [music] : melodramma in un prologo e tre atti /

Revised by Arrigo Boito; the libretto is based on A. García Gutiérrez's Simón Bocanegra. Cf. Loewenberg. Annals of opera.

Compendio histórico de la vida, virtudes, y fama posthuma del B. Simon de Roxas ... ; escrito con arreglo puntual à los procesos de su Beatificacion.

Mode of access: Internet.

Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells

The growth and differentiation of mesenchymal stem cells is controlled by various growth factors, the activities of which can be modulated by heparan sulfates. We have previously underscored the necessity of sulfated glycosaminoglycans for the FGF-2-stimulated differentiation of osteoprogenitor cells. Here we show that exogenous application of heparan sulfate to cultures of primary rat MSCs stimulates their proliferation leading to increased expression of osteogenic markers and enhanced bone nodule formation. FGF-2 can also increase the proliferation and osteogenic differentiation of rMSCs when applied exogenously during their linear growth. However, as opposed to exogenous HS, the continuous use of FGF-2 during in vitro differentiation completely blocked rMSC mineralization. Furthermore, we show that the effects of both FGF-2 and HS are mediated through FGF receptor 1 (FGFR1) and that inhibition of signaling through this receptor arrests cell growth resulting in the cells being unable to reach the critical density necessary to induce differentiation. Interestingly, blocking FGFR1 signaling in post-confluent osteogenic cultures significantly increased calcium deposition. Taken together our data clearly suggests that FGFR1 signaling plays an important role during osteogenic differentiation, firstly by stimulating cell growth that is closely followed by an inhibitory affect once the cells have reached confluence. It also underlines the importance of HS as a co-receptor for the signaling of endogenous FGF-2 and suggests that purified glycosaminoglycans may be attractive alternatives to growth factors for improved ex vivo growth and differentiation of MSCs.

Porcine bone marrow stromal cell differentiation on heparin-adsorbed poly (e-caprolactone)-tricalcium phosphate-collagen scaffolds

We evaluate the potential of heparin as a substrate component for the fabrication of bone tissue engineering constructs using poly(e- caprolactone)–tricalcium phosphate–collagen type I (PCL–TCP–Col) three-dimensional (3-D) scaffolds. First we explored the ability of porcine bone marrow precursor cells (MPCs) to differentiate down both the adipogenic and osteogenic pathways within 2-D culture systems, with positive results confirmed by Oil-Red-O and Alizarin Red staining, respectively. Secondly, we examined the influence of heparin on the interaction and behaviour of MPCs when seeded onto PCL–TCP–Col 3-D scaffolds, followed by their induction into the osteogenic lineage. Our 3-D findings suggest that cell metabolism and proliferation increased between days 1 and 14, with deposition of extracellular matrix also observed up to 28 days. However, no noticeable difference could be detected in the extent of osteogenesis for PCL–TCP–Col scaffolds groups with the addition of heparin compared to identical control scaffolds without the addition of heparin.

Sustained release and osteogenic potential of heparan sulfate-doped fibrin glue scaffolds within a rat cranial model

This paper explores the potential therapeutic role of the naturally occurring sugar heparan sulfate (HS) for the augmentation of bone repair. Scaffolds comprising fibrin glue loaded with 5 lg of embryonically derived HS were assessed, firstly as a release-reservoir, and secondly as a scaffold to stimulate bone regeneration in a critical size rat cranial defect. We show HS-loaded scaffolds have a uniform distribution of HS, which was readily released with a typical burst phase, quickly followed by a prolonged delivery lasting several days. Importantly, the released HS contributed to improved wound healing over a 3-month period as determined by microcomputed tomography (lCT) scanning, histology, histomorphometry, and PCR for osteogenic markers. In all cases, only minimal healing was observed after 1 and 3 months in the absence of HS. In contrast, marked healing was observed by 3 months following HS treatment, with nearly full closure of the defect site. PCR analysis showed significant increases in the gene expression of the osteogenic markers Runx2, alkaline phosphatase, and osteopontin in the heparin sulfate group compared with controls. These results further emphasize the important role HS plays in augmenting wound healing, and its successful delivery in a hydrogel provides a novel alternative to autologous bone graft and growth factorbased therapies.

Carbon monoxide and isocyanide complexes of trivalent uranium metallocenes

The [Cp′3U] metallocenes contain substituted cyclopentadienyl ligands and UIII with f3 electron configuration. They are good π donors and bind π-accepting ligands (L) such as carbon monoxide and isocyanides to form the corresponding adducts [Cp′3U(L)] (see scheme). The π-donating capability of the [Cp′3U] fragments appears to be readily modulated by the substituents on the cyclopentadienyl ligand.