Starina Moskvy i russkago naroda : v istoricheskom otnoshenii s bytovoi︠u︡ zhisnii︠u︡ russkikh, s opisaniem russkago narodnago byta v proshedshem i nachali︠e︡ nyni︠e︡shni︠a︡go stoli︠etii, nravov, obychaev, predanii, gul'bishch, uveselenii i proch.

Mode of access: Internet.

Valor do escore de calcio coronariano para prever a gravidade ou complexidade da doenca arterial coronariana

FUNDAMENTO: A previsão de gravidade ou complexidade da doença arterial coronariana (DAC) é valiosa devido ao aumento do risco de eventos cardiovasculares. Embora a associação entre o escore do cálcio arterial coronariano (CAC), e a gravidade da DAC pelo escore Gensini não tenha sido utilizado, já foi anteriormente demonstrado. Não há informações sobre a associação entre o escore do CAC total e a complexidade da DAC. OBJETIVOS: Investigar a associação entre a gravidade ou complexidade da doença arterial coronariana (DAC), avaliada pelo escore Gensini e SYNTAX (SS), respectivamente, e o escore do cálcio arterial coronariano (CAC), um método não invasivo para avaliação de DAC em pacientes sintomáticos com DAC significativa. MÉTODOS: Duzentos e quatorze pacientes foram incluídos. A pontuação total do CAC foi obtido antes da angiografia. A severidade e complexidade da DAC foram avaliadas pelo escore Gensini e SS, respectivamente. Foram analisadas as associações entre parâmetros clínicos e angiográficos e o escore total do CAC. RESULTADOS: A mediana do escore total do CAC foi de 192 (23,0-729,8), e correlacionou-se positivamente com ambos os escores Gensini (r: 0,299, p < 0,001) e ES (r: 0,577, p < 0,001). Na análise multivariada associou-se independentemente com a idade (ß: 0,154, p: 0,027), sexo masculino (ß: 0,126, p: 0,035) e ES (ß: 0,481, p < 0,001). A análise da curva ROC (Receiver Operating Characteristics) revelou um valor de corte > 809 para ES > 32 (tercil de SS alto). CONCLUSÃO: Em pacientes sintomáticos com DAC significativa, o escore total de CAC foi independentemente associado com SS e os pacientes com SS > 32 podem ser detectados através de escore Agatston alto.

The Relationship between GRACE Score and Epicardial Fat Thickness in non-STEMI Patients

Abstract Background: GRACE risk score (GS) is a scoring system which has a prognostic significance in patients with non-ST segment elevation myocardial infarction (non-STEMI). Objective: The present study aimed to determine whether end-systolic or end-diastolic epicardial fat thickness (EFT) is more closely associated with high-risk non-STEMI patients according to the GS. Methods: We evaluated 207 patients who had non-STEMI beginning from October 2012 to February 2013, and 162 of them were included in the study (115 males, mean age: 66.6 ± 12.8 years). End-systolic and end-diastolic EFTs were measured with echocardiographic methods. Patients with high in-hospital GS were categorized as the H-GS group (in hospital GS > 140), while other patients were categorized as the low-to-moderate risk group (LM-GS). Results: Systolic and diastolic blood pressures of H-GS patients were lower than those of LM-GS patients, and the average heart rate was higher in this group. End-systolic EFT and end-diastolic EFT were significantly higher in the H-GS group. The echocardiographic assessment of right and left ventricles showed significantly decreased ejection fraction in both ventricles in the H-GS group. The highest correlation was found between GS and end-diastolic EFT (r = 0.438). Conclusion: End-systolic and end-diastolic EFTs were found to be increased in the H-GS group. However, end-diastolic EFT and GS had better correlation than end-systolic EFT and GS.

Coalition formation in a contest game with three heterogeneous players

We analyze the incentives for cooperation of three players differing in their efficiency of effort in a contest game. We concentrate on the non-cooperative bargaining foundation of coalition formation, and therefore, we adopt a two-stage model. In the first stage, individuals form coalitions following a bargaining protocol similar to the one proposed by Gul (1989). Afterwards, coalitions play the contest game of Esteban and Ray (1999) within the resulting coalition structure of the first stage. We find that the grand coalition forms whenever the distribution of the bargaining power in the coalition formation game is equal to the distribution of the relative efficiency of effort. Finally, we use the case of equal bargaining power for all individuals to show that other types of coalition structures may be observed as well.

Simultaneous determination of gemifloxacin and diuretics in bulk, pharmaceutical dosage forms and human serum by RP-HPLC

An isocratic reversed phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of gemifloxacin and diuretics (hydrochlorothiazide and furosemide) in bulk, dosage formulations and human serum at 232 nm. Chromatographic separation was achieved on Purospher Start C18 (250 mm x 4.6 mm, 5 µm) column using mobile phase, methanol: water: acetonitrile (70:25:5 v/v/v) adjusted to pH 3.0 via phosphoric acid 85% having flow rate of 0.8 mL min -1 at room temperature. Calibration curves were linear over range of 0.5-10 µg mL -1 with a correlation coefficient ± 0.999. LOD and LOQ were in the ranges of 0.75-2.56 µg mL -1. Intra and inter-run precision and accuracy results were 98.26 to 100.9.

Simultaneous determination of moxifloxacin and H2 receptor antagonist in pharmaceutical dosage formulations by RP-HPLC: application to in vitro drug interactions

Simultaneous determination of moxifloxacin (MOX) and H2-antagonists was first time developed in bulk and formulations. Purospher STAR C18 (250 x 4.6 mm, 5 μm) column was used. The mobile phase (methanol: water: ACN, 60:45:5 v/v/v, pH 2.7) was delivered at a flow rate of 1.0 mL min-1, eluent was monitored at 236, 270 and 310 nm for cimetidine, famotidine and ranitidine, respectively. The proposed method is specific, accurate (98-103%), precise (intra-day and inter-day variation 0.098-1.970%) and linear (r>0.998). The LOD and LOQ were 0.006-0.018 and 0.019-0.005 μg mL-1, respectively. The statistical parameters were applied to verify the results. The method is applicable to routine analysis of formulations and interaction of MOX with H2-antagonist.

Sipoon Mörtträsketin kunnostussuunnitelma

Mörtträsketin perustilaselvitys, laskennallinen kuormitusselvitys ja näihin pohjautuva kunnostussuunnitelma tehtiin osana Uudenmaan elinkeino-, liikenne- ja ympäristökeskuksen ja Sipoon kunnan järvien kuntakohtaista kunnostusohjelmaa. Mörtträsket on matala, rehevä ja umpeenkasvava järvi, jossa ei ole toteutettu kunnostustoimenpiteitä. Järveä käytetään virkistyskäyttötarkoitukseen. Mörtträsketin tilaa on seurattu Ahtilan toipilaskodin jätevedenpuhdistamon vesistötarkkailuna säännöllisesti vuodesta 1969. Mörtträsket on ruskeavetinen ja runsashumuksinen sekä luokiteltavissa ravinteisuuden perusteella ylireheväksi, lisäksi se kärsii talviaikaisista happiongelmista sekä sisäisestä kuormituksesta. Mörtträsketin kasvillisuus on runsasta ja järven voi kasvillisuuden perusteella tulkita kärsivän rehevöitymisestä ja umpeenkasvusta. Selvää umpeenkasvua on jo havaittavissa erityisesti lahdelmissa, mutta myös avovesialueella. Merkittävimmät kasvilajit ovat ulpukka, järvikorte, leveäosmankäämi, kaitapalpakko ja sarat. Myös uposlehtistä pikkuvitaa esiintyy laajoilla alueilla. Ulkoinen kuormitus ei ole erityisen suurta, eikä merkittäviä pistekuormittajia ole. Kuitenkin Mörtträsketissä esiintyy runsasta vesikasvillisuutta, happiongelmia ja leväkukintoja ja vedenlaatu viittaa selkeästi rehevyysongelmiin. Tämän perusteella voidaan olettaa, että rehevyyttä ylläpitää sisäinen kuormitus. Mörtträsketin kunnostuksessa tulisi tavoitella parempaa happitilannetta ja vedenlaatua. Erityisen tärkeää on saada vähennettyä järven sisäistä kuormitusta. Sisäistä kuormitusta voidaan vähentää tehokalastuksella, hapetuksella ja kemiallisilla menetelmillä. Mörtträsketin kunnostamisessa suositellaan fosforin kemiallista saostamista yhtä aikaa vesikasvien maltillisen poistamisen kanssa. Poistot voidaan tehdä joko niittämällä tai ruoppaamalla. Molemmat edellyttävät tarkempia suunnitelmia. Samaan aikaan kannattaa lisätä happipitoisuuden seurantaa, jotta hapetussuunnitelman tekeminen olisi mahdollista. Lisäksi saostuksen vaikutuksia tulee arvioida vedenlaatunäytteiden avulla. Tässä vaiheessa voidaan miettiä hapetuksen tarpeellisuutta uudelleen hapetussuunnitelman yhteydessä.

Liver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitis

The aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 µg/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body weight). The degree of hepatic cell degeneration differed significantly between groups. Mean malondialdehyde levels were 7.00 ± 2.29, 20.89 ± 10.13, 11.52 ± 4.60, 18.69 ± 8.56, and 8.58 ± 3.68 nmol/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Mean catalase activity was 3.20 ± 0.83, 1.09 ± 0.35, 2.05 ± 0.91, 1.70 ± 0.60, and 2.85 ± 0.47 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively, and mean glutathione peroxidase activity was 0.72 ± 0.25, 0.33 ± 0.09, 0.37 ± 0.04, 0.34 ± 0.07 and 0.42 ± 0.1 U/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Cerulein-induced liver damage was accompanied by a significant increase in tissue malondialdehyde levels (P < 0.05) and a significant decrease in catalase (P < 0.05) and GPx activities (P < 0.05). L-arginine and pentoxifylline, but not L-NAME, protected against this damage. Oxidative injury plays an important role not only in the pathogenesis of AP but also in pancreatitis-induced hepatic damage.

Recueil fait à l'abbaye de Saint Victor de Paris, comprenant divers opuscules théologiques, des extraits des Pères, des prières, des gloses, des vers, etc.

"Liber Celestini pape qui vocatur de contemptu mundi. (65). Notabilia super Magnificat a de Jarsono (80). Expositio s. Augustini super VII psalmos (97). Colloquium B. Ambrosii ad J. C. (124)".