Groove pancreatitis a propósito de um caso clínico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Stiffness and damping coefficients of 3-axial groove water lubricated bearing using perturbation technique

A Computational fluid dynamics (CFD) approach is used to model fluid flow in a journal bearing with three equi-spaced axial grooves and supplied with water from one end. Water is subjected to both velocity (Couette) & pressure induced (Poiseuille) flow. The working fluid passing through the bearing clearance generates driving force components that may increase the unstable vibration of the rotor. It is important to know the accurate rotor dynamic force component for predicting the instability of rotor bearing systems. In this paper a study has been made to obtain the stiffness and damping coefficients of 3 axial groove bearing using Perturbation technique.

Getting in the Groove : The Recording Studio Procedural Guide

This paper examines time management in the recording studio from the perspective of the music producer. The paper is presented in the form of a guide that will provide a common language to music clientele and technical personnel to help achieve the best possible creative outcome. The research for the guide combined the author's experience, literary evidence and external assessment to work towards establishing a practical industry resource. The result of the study explored how the success of any recording project can be forecast before valuable resources are committed. The feedback from the survey group was positive and some professionals recognised an immediate application for the procedural guide, which exceeded the author's expectations.

Coupling of energy from quantum emitters to the plasmonic mode of V groove waveguides: A numerical study

This work is a theoretical investigation into the coupling of a single excited quantum emitter to the plasmon mode of a V groove waveguide. The V groove waveguide consists of a triangular channel milled in gold and the emitter is modeled as a dipole emitter, and could represent a quantum dot, nitrogen vacancy in diamond, or similar. In this work the dependence of coupling efficiency of emitter to plasmon mode is determined for various geometrical parameters of the emitter-waveguide system. Using the finite element method, the effect on coupling efficiency of the emitter position and orientation, groove angle, groove depth, and tip radius, is studied in detail. We demonstrate that all parameters, with the exception of groove depth, have a significant impact on the attainable coupling efficiency. Understanding the effect of various geometrical parameters on the coupling between emitters and the plasmonic mode of the waveguide is essential for the design and optimization of quantum dot–V groove devices.

Svengi ja groove rytmimusiikissa : Rytmiikkaan ja hienorytmiikkaan keskittyvä vertaileva musiikkianalyysi

Käsitteillä svengi ja groove viitataan useimmiten kappaleen tietyn tulkinnan eli esityksen pääasiallisesti rytmisten ominaisuuksien laatuun. Tutkimuksen tavoitteena on kehittää musiikin rytmiikkaan ja hienorytmiikkaan keskittyviä musiikkikognitiivisia analyysimetodeja, joita soveltamalla nämä ominaisuudet voitaisiin tavoittaa. Käsitteiden monitulkintaisuus, joka tuodaan esiin tutkimuksen alussa aiheuttaa tälle monenlaisia haasteita. -- Tutkimuksen rytmiikkaan keskittyviä analyysimetodeja sovellettaessa musiikkia tarkastellaan tietystä esityksestä tehdyn nuottiesityksen, transkription välityksellä. Hienorytmisiä analyysimetodeja käytettäessä musiikkia tarkastellaan esitysten instrumenttiosuuksien sävelten alukehetkien tarkkojen sijaintien kautta. Alukehetket poimitaan erilaisin automaattisin ja manuaalisin tietokoneavusteisin menetelmin äänitteiltä. Tutkimuksessa tarkastellaan musiikissa esiintyviä ilmiöitä myös laajemmalla, musiikin havaitsemiseen ja tuottamiseen yleisesti liittyvällä musiikkikognition tasolla. Tärkeänä näkökulmana musiikin rytmiikan esitetään jakautuvan kognitiivisesti karkeampaan tekstuaaliseen rytmiikkaan ja tätä hienoisesti varioivaan ei-tekstuaaliseen hienorytmiikkaan. Analyysiosuudessa kehitettyjä metodeja sovelletaan seuraavien kappaleiden soolo-osuuksiin: Miles Davis – 'Freddie Freeloader' (1959), James Brown – 'Doing it to Death' (1973) ja Led Zeppelin – 'Stairway to Heaven' (1971). Kappaleet edustavat tutkimuksessa jazz-, funk- ja rock-tyylilajeja. Analyysi tarkastelee ja vertailee kappaleiden metristä stabiiliutta, instrumenttiosuuksien suhdetta pulssin iskuihin, rytmiikan kolmimuunteisuutta, soolojen metrisiä painopisteitä, soolojen rytmistä tiheyttä sekä tempojen muutoksia. -- Kehitetyt menetelmät osoittautuvat kaikki käyttökelpoisiksi. Kappaleille yhteiseksi piirteeksi paljastuu instrumenttiosuuksien säännönmukainen sijoittuminen pulssin iskuihin nähden kappaleiden sisällä. Kappaleiden välillä eri instrumentit sijoittuvat kuitenkin pulssin ympärille eroavin tavoin, jonka oletetaan johtuvan ennen kaikkea tyylilajien eroista. Tempot pysyvät kappaleissa varsin muuttumattomina. Jatkotutkimuksen kannalta mielenkiintoisia näkymiä ovat muun muassa metodien laajempi soveltaminen, automaattisten menetelmien kehittäminen

Inflammatory and coagulation disturbances in acute pancreatitis

Acute pancreatitis (AP), a common cause of acute abdominal pain, is usually a mild, self-limited disease. However, some 20-30% of patients develop a severe disease manifested by pancreatic necrosis, abscesses or pseudocysts, and/or extrapancreatic complications, such as vital organ failure (OF). Patients with AP develop systemic inflammation, which is considered to play a role in the pathogenesis of multiple organ failure (MOF). OF mimics the condition seen in patients with sepsis, which is characterized by an overwhelming production of inflammatory mediators, activation of the complement system and systemic activation of coagulation, as well as the development of disseminated intravascular coagulation (DIC) syndrome. Vital OF is the major cause of mortality in AP, along with infectious complications. About half of the deaths occur within the first week of hospitalization and thus, early identification of patients likely to develop OF is important. The aim of the present study was to investigate inflammatory and coagulation disturbances in AP and to find inflammatory and coagulation markers for predicting severe AP, and development of OF and fatal outcome. This clinical study consists of four parts. All of patients studied had AP when admitted to Helsinki University Central Hospital. In the first study, 31 patients with severe AP were investigated. Their plasma levels of protein C (PC) and activated protein C (APC), and monocyte HLA-DR expression were studied during the treatment period in the intensive care unit; 13 of these patients developed OF. In the second study, the serum levels of complement regulator protein CD59 were studied in 39 patients during the first week of hospitalization; 12 of them developed OF. In the third study, 165 patients were investigated; their plasma levels of soluble form of the receptor for advanced glycation end products (sRAGE) and high mobility group box 1 (HMGB1) protein were studied during the first 12 days of hos-pitalization; 38 developed OF. In the fourth study, 33 patients were studied on admission to hospital for plasma levels of prothrombin fragment F1+2 and tissue factor pathway inhibitor (TFPI), and thrombin formation capacity by calibrated automated thrombogram (CAT); 9 of them developed OF. Our results showed significant PC deficiency and decreased APC generation in patients with severe AP. The PC pathway defects seemed to be associated with the development of OF. In patients who developed OF, the levels of serum CD59 and plasma sRAGE, but not of HMGB1, were significantly higher than in patients who recovered without OF. The high CD59 levels on admission to the hospital seemed to be predictive for severe AP and OF. The median of the highest sRAGE levels was significantly higher in non-survivors than in survivors. No significant difference between the patient groups was found in the F1+2 levels. The thrombograms of all patients were disturbed in their shape, and in 11 patients the exogenous tissue factor did not trigger thrombin generation at all ( flat curve ). All of the patients that died displayed a flat curve. Free TFPI levels and free/total TFPI ratios were significantly higher in patients with a flat curve than in the others, and these levels were also significantly higher in non-survivors than in survivors. The flat curve in combination with free TFPI seemed to be predictive for a fatal outcome in AP.

Drop impact on a solid surface comprising micro groove structure

Spreading and receding processes of water drops impacting on a stainless steel surface comprising rectangular shaped parallel grooves are studied experimentally. The study was confined to the impact of drops in inertia dominated flow regime with Weber number in the range 15 - 257. Measurements of spreading drop diameter and drop height were obtained during the impact process as function of time. Experimental measurements of spreading drop diameter and drop height obtained for the grooved surface were compared with those obtained for a smooth surface to elucidate the influence of surface grooves on the impact process. The grooves definitely influence both spreading and receding processes of impacting liquid drops. A more striking observation from this study is that the receding process of impacting liquid drops is dramatically changed by the groove structure for all droplet Weber number.

Complex trait of acute pancreatitis : Studies of candidate genes and adipokines

Acute pancreatitis (AP) is a common disease. Mild disease resolves spontaneously in a few days. Severe forms of the disease can lead to local complications, necrosis, and abscesses in and around the pancreas. Systemic inflammation in severe AP is associated with distant organ failures. The aim of this study is to identify genetically determined prognostic factors involved in the clinical features of AP. The study employs a candidate-gene approach, and the genes are involved in trysinogen activation in the initiation phase of the disease, as well as in the systemic inflammation as the disease proceeds. The last study examines adipokines, fat-derived hormones characterized with the capacity to modify inflammation. SPINK 1 is a gene coding trypsin activation inhibitor. Mutations N34S and P55N were determined by minisequencing methods in 371 AP patients and in 459 controls. The mutation N34S was more common in AP patients (7.8%) than in controls (2.6%). This suggests that SPINK 1 gene mutation N34S is a risk factor for AP. In the fourth study, in 12 matched pairs of patients with severe and mild AP, levels of adipokines, adiponectin, and leptin were evaluated. Plasma adipokine levels did not differ between patients with mild and severe AP. The results suggest that in AP, adipokine plasma levels are not factors predisposing to organ failures. This study identified the SPINK 1 mutation N34S to be a risk factor for AP in the general population. As AP is a multifactorial disease, and extensive genetic heterogeneity is likely, further identification of genetic factors in the disease requires larger future studies with more advanced genetic study models. Further identification of the patient characteristics associated with organ failures offers another direction of the study to achieve more detailed understanding of the severe form of AP.