Allergie ou intolérance alimentaire [Food allergy or food intolerance?].

Adverse food reactions can be classified into two main categories depending on wether an immune mechanism is involved or not. The first category includes immune mediated reactions like IgE mediated food allergy, eosinophilic oesophagitis, food protein-induced enterocolitis syndrome and celiac disease. The second category implies non-immune mediated adverse food reactions, also called food intolerances. Intoxications, pharmacologic reactions, metabolic reactions, physiologic, psychologic or reactions with an unknown mechanism belong to this category. We present a classification of adverse food reactions based on the pathophysiologic mechanism that can be useful for both diagnostic approach and management.

Unusual antibiotic presence in gym trained subjects with food intolerance: a case report

Introduction: Great interest is raising in food intolerances due to the lack, in many cases, of a particular sensitizing agent. Objective: We investigated the serum level of possible new haptens in 15 heavy meat consumers for sport fitness affected by various kinds of food intolerance and who had ever been administered antibiotics in their life for clinical problems. Methods: Forty ml of blood were drawn from each patient and analyzed, by means of an ELISA test, in order to possibly identify the presence of an undue contaminant with hapten properties. Results: Four out of fifteen subjects (26%) showed a serum oxytetracycline amount > 6 ng/g (which is considered the safety limit), 10 of 15 (66%) a serum doxycycline amount > of 6 ng/g and 3 out of 15 (30%) subjects had high serum level of both molecules. Conclusions: Although a direct ratio between body antibiotics remnant storage in the long run and chronic gut dysfunctions and/or food allergy did not reached the evidence yet, the blood traces of these compounds in a food intolerant otherwise healthy population might be considered the preliminary putative step of a sensitizing pathway. Our next goals foresee a deeper insight into the sensitizing trigger from human chronic antibiotic exposure via the zootechnical delivery of poultry food.

Star dust memories, or how to detect allergen traces in powder foods

Allergies and food intolerances are at the forefront of institutional interest (European Regulation No 1169/2011) for their impact on consumer health. Allergies to peanuts and other nuts and gluten intolerance, makes production processes involving mixtures of powders a great concern for the industry, given the need to indicate the existence of traces of any of them. The food industry requires non-destructive and non-invasive methods of quantification that meet sensitivity requirements but also specificity levels. Optical methods such as NIR spectrophotometry or hyper-spectral image are currently some of the technologies that show potential success. This is the context of this paper that evaluates how to use NIR spectroscopy (900-1600nm) to detect traces of 15 different kinds of nuts and 20 other flours.

Untersuchungen zu Qualität und Verträglichkeit ökologischer Milch

In der Literatur findet sich eine kontroverse Debatte um eine Differenzierbarkeit ökologischer und konventioneller Produktqualität von Lebensmitteln. Zugleich greifen zahlreiche subjektiv überzeugte Verbraucher zunehmend zu ökologischen Lebensmitteln. Als eines der Kaufmotive wird in vielen Umfragen die Annahme eines höheren Gesundheitswertes und allgemein einer höheren Qualität ökologischer Produkte genannt. Bisher besteht hinsichtlich der Definitionen, Methoden sowie der Einordnung ökologischer Produktqualität keine Einigkeit. Hinsichtlich von Milch zeigen erste Untersuchungen Unterschiede in der inhaltsstofflichen Zusammensetzung. Differenzierungsmarkern aus der Gruppe der Fettsäuren u.a. n-3, CLA sowie spezifischen TFA werden ernährungsphysiologische Wirksamkeit zugesprochen. Wie aber wirkt sich die Produktion in unterschiedlichen Intensitäten sowohl in der konventionellen als auch in der ökologischen Milchviehhaltung auf die Produktqualität aus? Und lässt sich ökologische bzw. biologisch-dynamische von konventioneller Milch differenzieren? Die Arbeit geht der Qualität ökologischer, speziell biologisch-dynamischer Milch nach und prüft in einem ersten Schritt die Verträglichkeit biologisch-dynamischer Vorzugsmilch bei Kindern mit Nahrungsmittelunverträglichkeiten auf Milch. Dabei gliedert sich die Arbeit in drei aufeinander aufbauende Teilbereiche. Das Kapitel 2 „Ökologische Lebensmittel und Produktqualität“ enthält eine Literaturauswertung zur Verwendung des Begriffes „Struktur“ in der Diskussion um die Beurteilung ökologischer Lebensmittel. Die Beschäftigung mit der Begriffsbildung im Zusammenhang mit der Bestimmung ökologischer Produktqualität und den zugrundeliegenden Konzepten sowie der gegenwärtige Entwicklungsstand werden in den folgenden beiden Kapiteln fortgeführt und vertieft. Zudem wird anhand der Arbeitsergebnisse aus Workshops der internationalen Assoziation wissenschaftlicher Institute „Organic Food Quality and Health“ (FQH) und den in diesem Zusammenhang geführten Arbeits- und Abstimmungsprozessen zur weiteren Vorgehensweise bei der Beurteilung ökologischer Lebensmittel dargestellt. Die entwickelten Kriterien dienten zugleich als eine Art Blaupause für die wissenschaftliche Vorgehensweise in diesem Promotionsprojekt und die konkrete Durchführung dieser Studie. In Kapitel 3 „Systemvergleich und Differenzierbarkeit biologisch-dynamischer und konventioneller Milch auf Betriebsebene“ stehen die Ergebnisse und Auswertungen des Systemvergleiches der Milchqualität von konventionellen und ökologischen bzw. biologisch-dynamischen Betrieben in low- bis high-input Orientierung an zentraler Stelle. Der Wissensstand hinsichtlich der Differenzierbarkeit von Milch wird aus der Literatur referiert. Auf Grundlage von u.a. Fettsäuren- und Antioxidantienanalytik wird die Differenzierbarkeit von ökologischer Milch im Sommer wie auch im Winter einer Einordnung und Bewertung unterzogen. Es werden die Möglichkeiten der Differenzier- und Authentifizierbarkeit anhand verschiedener Inhaltsstoffmarker (Fettsäuren, Antioxidantien und Phytansäure) von Milch aus ökologischen und anderen Produktionssystemen dargestellt. Abschließend werden Implikationen für die landwirtschaftliche Praxis in der ökologischen Milchviehhaltung dargestellt. Das Kapitel 4 „Ökologische Milch und Gesundheit“ stellt erste Ergebnisse zur Auswirkung der Produktqualität von Milch auf die Gesundheit des Menschen vor, die in der Zusammenarbeit mit Dr. med. T. Roos entstanden sind. Er führte die Verträglichkeitstestungen im Rahmen unserer Pilotstudie mit Milch unterschiedlicher Herkunft bei Kindern mit Nahrungsmittelallergien durch und konnte eine erstaunlich hohe Toleranz der biologisch-dynamischen Vorzugsmilch im Vergleich zu konventioneller Standardmilch (pasteurisiert, homogenisiert) feststellen. Mit welchen Faktoren in der Produktion und bei der Weiterverarbeitung der Milch dies zu erklären ist, muss in weiteren Untersuchungen zu den qualitativen Zwischenschritten erfolgen. Die Ergebnisse dieser und anderer Studien weisen darauf hin, dass nur gering intensivierte ökologische Milchviehbetriebe, die regelmäßigen Weidegang und möglichst geringe Kraftfutter- und Mais-Fütterung praktizieren, Milch mit einer deutlich differenzierbaren Produktqualität gegenüber durchschnittlicher konventioneller Milch erzeugen. Vor dem Hintergrund wirtschaftlicher Zwänge zu stärkerer Intensivierung geben die vorgelegten Ergebnisse Anlass, die Kriterien der Ausrichtung ökologischer Milchproduktion so zu bestimmen, dass eine „authentische“ ökologische Produktqualität realisiert werden kann. Auch über die ökologische Milchwirtschaft hinaus sind die Ergebnisse dieser Studie von Interesse. Sie hat am Beispiel von Milch in exemplarischer Weise die für eine Qualifikationsbestimmung auch von gesundheitlicher Relevanz erforderliche Kette von Schritten bis hin zum Menschen vollzogen. Die in dieser Studie insbesondere in Bezug auf die Fettsäuren Zusammensetzung gezeigten Qualitätsmerkmale ökologischer und biologisch-dynamischer Milch weisen auf ein auch ernährungsphysiologisch interessantes Alleinstellungsmerkmal der Produktqualität hin, welches die Annahmen gesundheitsbewusster Verbraucher zu bestätigen vermag und dazu verhelfen mag für ökologische Milch und Milchprodukte höhere Preise zu generieren. Im Blick auf die immer wieder neu geführte Diskussion um die Geltung und Konkretisierung der Grundprinzipien des Ökologischen Landbaus kommt dieser Studie besondere Bedeutung zu.

[food Insecurity In Brazilian Families With Children Under Five Years Of Age].

This article analyzes food insecurity and hunger in Brazilian families with children under five years of age. This was a nationally representative cross-sectional study using data from the National Demographic and Health Survey on Women and Children (PNDS-2006), in which the outcome variable was moderate to severe food insecurity, measured by the Brazilian Food Insecurity Scale (EBIA). Prevalence estimates and prevalence ratios were generated with 95% confidence intervals. The results showed a high prevalence of moderate to severe food insecurity, concentrated in the North and Northeast regions (30.7%), in economic classes D and E (34%), and in beneficiaries of conditional cash transfer programs (36.5%). Multivariate analysis showed that the socioeconomic relative risks (beneficiaries of conditional cash transfers), regional relative risks (North and Northeast regions), and economic relative risks (classes D and E) were 1.8, 2.0 and 2.4, respectively. Aggregation of the three risks showed 48% of families with moderate to severe food insecurity, meaning that adults and children were going hungry during the three months preceding the survey.

Evaluation Of The Location Of Capsules Swallowed With Food During The Pharyngeal Phase Triggering In Asymptomatic Adults.

To assess the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. The location of the bolus during the pharyngeal phase triggering provides information about the sensorimotor model of the beginning of deglutition onset. To evaluate the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. A videofluoroscopy swallowing study was carried out in 60 subjects (14 male and 46 female participants) aged between 27 and 55 years, who were evaluated with hard gelatin capsules #00 and #3 containing barium sulfate, swallowed with liquid food and pudding, in free volume. The first laryngeal elevation movement was the criterion to locate the pharyngeal phase triggering. Statistical analysis was based on the McNemar test. Capsule #3 presented higher percentage of location in the tongue dorsum compared to capsule #00, and capsule #00 presented higher percentage of location in the tongue base and vallecula compared to capsule #3. There was a difference between different capsules swallowed with liquid (p=0.016) and pudding (p=0.037). The capsule size influenced the location of the pharyngeal phase triggering. Smaller capsules started pharyngeal phase in the most anterior region (tongue dorsum) compared to larger capsules.

Mechanisms Of Insulin Resistance In The Amygdala: Influences On Food Intake.

Obesity is increasing worldwide and is triggered, at least in part, by enhanced caloric intake. Food intake is regulated by a complex mechanism involving the hypothalamus and hindbrain circuitries. However, evidences have showing that reward systems are also important in regulating feeding behavior. In this context, amygdala is considered a key extra-hypothalamic area regulating feeding behavior in human beings and rodents. This review focuses on the regulation of food intake by amygdala and the mechanisms of insulin resistance in this brain area. Similar to the hypothalamus the anorexigenic effect of insulin is mediated via PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B) pathway in the amygdala. Insulin decreases NPY (neuropeptide Y) and increases oxytocin mRNA levels in the amygdala. High fat diet and saturated fatty acids induce inflammation, ER (endoplasmic reticulum) stress and the activation of serine kinases such as PKCθ (protein kinase C theta), JNK (c-Jun N-terminal kinase) and IKKβ (inhibitor of nuclear factor kappa-B kinase beta) in the amygdala, which have an important role in insulin resistance in this brain region. Overexpressed PKCθ in the CeA (central nucleus of amygdala) of rats increases weight gain, food intake, insulin resistance and hepatic triglycerides content. The inhibition of ER stress ameliorates insulin action/signaling, increases oxytocin and decreases NPY gene expression in the amygdala of high fat feeding rodents. Those data suggest that PKCθ and ER stress are main mechanisms of insulin resistance in the amygdala of obese rats and play an important role regulating feeding behavior.

Jaguarundi (Puma yagouaroundi) (Geoffroy, 1803) (Carnivora, Felidae) food habits in a mosaic of Atlantic Rainforest and eucalypt plantations of southeastern Brazil

Food habits of jaguarundi (Puma yagouaroundi) (Geoffroy, 1803) (Carnivora, Felidae) were studied between November 2000 and November 2001, in a 24.9 km² area of secondary Atlantic Rainforest and eucalypt plantation, in the Serra de Paranapiacaba, São Paulo State, Brazil. Analyses of 26 fecal and regurgitate samples, obtained over a stretch of 570.1 km, showed the consumption of 19 prey items and 74 prey occurrences. Small mammals were the most frequent food item (42.5%), followed by birds (21%), reptiles (14%) and medium-sized mammals (3%). The percent occurrence (PO) suggests that the diet consisted mainly of small rodents (30%) and birds (21%). We recorded for the first time the predation of Viperidae snakes by P. yagouaroundi. Although having a large list of items and range of dietary niche breadths (Bsta = 0.76), our data show that jaguarundi prey mainly on small vertebrates (mammals, birds or reptiles), and even in tall tropical forests or eucalypt plantations, it preys mostly on animals that come to, or live on, the ground.

Validation of a food frequency questionnaire to assess the consumption of carotenoids, fruits and vegetables among adolescents: the method of triads

The aim of this study was to validate the intake of carotenoids, fruits and vegetables estimated by the Food Frequency Questionnaire for Adolescents (FFQA) using the method of triads. Blood samples were collected from 80 elementary school adolescents to assess serum levels of β-carotene. Partial correlation coefficients (r) were calculated between an estimated intake of carotenoids, fruits and vegetables and the serum levels of β-carotene. Validity coefficients were calculated using the method of triads. With the exception of carotenoids, partial r from the food frequency questionnaire (FFQ) were greater than those of the 24-hour recall (24hR). The fruit/vegetable group showed the highest partial r for the FFQ (r = 0.235) and the 24hR (r = 0.137). The highest validity coefficient was obtained for the vegetable group, as assessed by the FFQ (r = 0.873). On average, the validity coefficient values for the FFQ were greater than those obtained for the 24hR or the β-carotene serum levels. The FFQA is an accurate tool for estimating the intake of carotenoids, fruits and vegetables in this population group.

Assessing the validity of a food frequency questionnaire among low-income women in São Paulo, southeastern Brazil

This study describes the validity of a food frequency questionnaire (FFQ) in 93 low-income women (20-65 years), participating in a case-control study in São Paulo, Brazil. Two FFQ (FFQ1 and FFQ2, 12 months apart) and three 24-hour dietary recalls (24hR) were conducted between 2003 and 2004 to estimate dietary intake during the past year. The Pearson correlation coefficients (crude, energy-adjusted and de-attenuated) were used for comparisons between FFQ and 24hR. The agreement between the methods was further examined by the Bland-Altman analysis. For the assessment of long-term reliability, the energy-adjusted intra-class correlation coefficients were mostly around 0.40, but higher for vitamin A and folate (0.50-0.56). Energy-adjusted, attenuation-corrected Pearson validity correlations between FFQ and DR ranged from 0.30-0.54 for macronutrients to 0.20-0.48 for micronutrients, with higher value for calcium (0.75). There were small proportions of grossly misclassified nutrient intakes, while Bland-Altman plots indicated that the FFQ is accurate in assessing nutrient intake at a group level.

Influence of food components on lipid metabolism: scenarios and perspective on the control and prevention of dyslipidemias

Cardiovascular diseases (CVD) are the main causes of death in the Western world. Among the risk factors that are modifiable by diet, for reducing cardiovascular disease risks, the total plasma concentrations of cholesterol, triglycerides, LDL-C, and HDL-C are the most important. Dietary measures can balance these components of the lipid profile thus reducing the risk of cardiovascular diseases. The main food components that affect the lipid profile and can be modified by diet are the saturated and trans fats, unsaturated fats, cholesterol, phytosterols, plant protein, and soluble fiber. A wealth of evidence suggests that saturated and trans fats and cholesterol in the diet raise the total plasma cholesterol and LDL-C. Trans fats also reduce HDL-C, an important lipoprotein for mediating the reverse cholesterol transport. On the other hand, phytosterols, plant proteins, isoflavones, and soluble fiber are protective diet factors against cardiovascular diseases by modulating plasma lipoprotein levels. These food components at certain concentrations are able to reduce the total cholesterol, TG, and LDL-C and raise the plasma levels of HDL-C. Therefore, diet is an important tool for the prevention and control of cardiovascular diseases, and should be taken into account as a whole, i.e., not only the food components that modulate plasma concentrations of lipoproteins, but also the diet content of macro nutrients and micronutrients should be considered.

Assessing food dietary intakes in Japanese-Brazilians using factor analysis

We describe the use of factor analysis for assessing food habits in Japanese-Brazilians. Dietary data from 1,283 participants of a cross-sectional study were used. Besides statistical criteria, we also used the conceptual meaning of identified profiles to obtain scores for dietary patterns (Japanese or Western profile). Paired Student t test, linear regression and Poisson models were used to verify the existence of relationship between these scores and generation, body mass index (BMI), waist circumference and presence of metabolic syndrome, respectively. First generation subjects had higher mean Japanese profile scores and lower Western profile scores than those of second generation. The Western dietary pattern was associated with BMI (p = 0.001), waist circumference (p = 0.023) and metabolic syndrome (p < 0.05). We concluded that these scores were able to discriminate subjects who maintained their traditional Japanese lifestyle or otherwise, and that the incorporation of a Western lifestyle is associated to high values of BMI, waist circumference and presence of metabolic syndrome.

Diet and cancer in Northeast Brazil: evaluation of eating habits and food group consumption in relation to breast cancer

Realizou-se um estudo do tipo caso-controle de base hospitalar no Município de João Pessoa, Paraíba, Brasil. Participaram 183 indivíduos (89 casos e 94 controles) na faixa etária entre 30 e 80 anos, com pareamento por idade. O consumo alimentar de casos e controles foi avaliado por alimentos e grupos de alimentos categorizados em tercis de consumo. A estimativa dos valores da odds ratio (OR) e intervalos de confiança de 95% (IC95%) foi realizada por regressão logística múltipla não-condicional. O consumo de frutas e sucos, feijão e leite e derivados apresentou uma forte associação com a redução no risco de câncer de mama. O consumo de carnes vermelhas e de carnes fritas esteve positivamente associado ao risco de câncer de mama (carne vermelha - OR = 4.30; IC95%: 1,74-10,67; p = 0,00). Não foi observada associação entre o consumo dos grupos de vegetais e embutidos com o câncer de mama. Carne vermelha e carnes fritas podem ser fatores de risco, e o consumo de frutas, feijão e leite e derivados pode atuar como protetor do câncer de mama

Sugar and total energy content of household food purchases in Brazil

Objective To study the role of energy derived from sugar (both table sugar and sugar added to processed foods) in the total energy content of food purchases in Brazil.Design Food purchase data were collected during a national household budget survey carried out between June 2002 and July 2003 on a probabilistic sample representative of all households in the country. The amount of food purchased in this 12-month period was transformed into energy and energy from sugar using food composition tables. Multiple linear regression models were used to study the association between amount of energy from sugar and total energy content of food purchases, controlling for sociodemographic variables and potential interactions between these variables and sugar purchases.Results There was a positive and significant association between energy from sugar and total household energy purchases. A 1 kJ increase in sugar purchase corresponded to a 3·637 kJ increase in total energy. In the absence of expenditure on meals outside the home, i.e. when household food purchases tend to approximate actual food consumption by household members, sugar purchase of 1926·35 kJ/d (the 90th percentile of the distribution of sugar purchases in Brazil) was associated, depending on income strata, with total energy purchase over 40\201360 per cent of the recommended daily value for energy intake in Brazil.Conclusions The present results corroborate the recommendations of the WHO and the Brazilian Ministry of Health regarding limiting the consumption of sugar