Safety of non-therapeutic atomoxetine exposures - a national poison data system study

AIMS This study's objective is to assess the safety of non-therapeutic atomoxetine exposures reported to the US National Poison Database System (NPDS). METHODS This is a retrospective database study of non-therapeutic single agent ingestions of atomoxetine in children and adults reported to the NPDS between 2002 and 2010. RESULTS A total of 20 032 atomoxetine exposures were reported during the study period, and 12 370 of these were single agent exposures. The median age was 9 years (interquartile range 3, 14), and 7380 were male (59.7%). Of the single agent exposures, 8813 (71.2%) were acute exposures, 3315 (26.8%) were acute-on-chronic, and 166 (1.3%) were chronic. In 10 608 (85.8%) cases, exposure was unintentional, in 1079 (8.7%) suicide attempts, and in 629 (5.1%) cases abuse. Of these cases, 3633 (29.4 %) were managed at health-care facilities. Acute-on-chronic exposure was associated with an increased risk of a suicidal reason for exposure compared with acute ingestions (odds ratio 1.44, 95% confidence interval 1.26-1.65). Most common clinical effects were drowsiness or lethargy (709 cases; 5.7%), tachycardia (555; 4.5%), and nausea (388; 3.1%). Major toxicity was observed in 21 cases (seizures in nine (42.9%), tachycardia in eight (38.1%), coma in six (28.6%), and ventricular dysrhythmia in one case (4.8%)). CONCLUSIONS Non-therapeutic atomoxetine exposures were largely safe, but seizures were rarely observed.

Identification of maltreatment type in children with disabilities using the National Child Abuse and Neglect Data System (NCANDS)

This study was a retrospective design and used secondary data from the National Child Abuse and Neglect Data System (NCANDS), provided by the National Data Archive on Child Abuse and Neglect Family Life Development Center administered by Cornell University. The dataset contained information for the year 2005 on children from birth to 18 years of age. Child abuse and neglect for disabled children, was evaluated in-depth in the present study. Descriptive and statistical analysis was performed using the children with and without disabilities. It was found that children with disabilities have a lower rate of substantiation that likely indicates the interference of reporting due to their handicap. The results of this research demonstrate the important need to teach professionals and laypersons alike on how to recognize and substantiate abuse among disabled children.^

National accident sampling system crashworthiness data system 1988-1990.

Mode of access: Internet.

National accident sampling system crashworthiness data system 1991-1993.

Mode of access: Internet.

National automotive sampling system crashworthiness data system 1992-1994.

Mode of access: Internet.

National automotive sampling system crashworthiness data system 1993-1995.

Mode of access: Internet.

National automotive sampling system crashworthiness data system 1994-1996.

Mode of access: Internet.

National automotive sampling system crashworthiness data system 1995-1997.

Mode of access: Internet.

A pilot study of nuclear medicine reporting through the Medically Oriented Data System /

Mode of access: Internet.

Pilot climate data system.

Cover title.

Federal energy data system (FEDS) : technical documentation /

"DOE/EIA-0031/1. CRN78030l-00087. SP-MN."

A study of the Air Force maintenance technical data system,

ASTIA document AD 288 636.

Integrated Postsecondary Education Data System : glossary /

"CS 86-313"--Doc. resume.

National Child Abuse and Neglect Data System.

"This document has been prepared under contarct number ACF-105-91-1802 for the National Center on Child Abuse and Neglect by Water R. McDonald & Associates, Inc., Bowers & Associates, and the American Humane Association."--P. 2 of cover.